Glucose metabolism during liver transplantation in dogs

Arterial and hepatic venous blood levels of glucose were studied in 12 dogs during orthotopic liver transplantation peformed under ketamine anesthesia without exogenous glucose administration. During the early part of surgery, arterial blood glucose levels were stable: 161 ± 12 mg/dl (mean ± SEM) after laparotomy and 183 ± 16 mg/dl 5 min before the anhepatic stage. During the anhepatic stage, arterial blood glucose levels decreased progressively to 135 ± 9 and 88 ± 8 mg/dl, 5 min in the anhepatic stage and 5 min before reperfusion of the graft liver, respectively (P < 0.05). Reperfusion of the graft liver resulted in an increase in arterial glucose levels to 206 ± 17 and 240 ± 24 mg/dl, 5 and 30 min after reperfusion, respectively (P < 0.05). Hepatic venous blood glucose levels increased after reperfusion (405 ± 37 and 346 ± 41 mg/dl, 5 and 30 min after reperfusion, respectively) and were significantly higher than in arterial blood (P < 0.05). Arterial lasma insulin, measured in 5 animals, did not change significantly during the procedure, whereas plasma glucagon levels, stable during the preanhepatic and anhepatic stages, increased steadily after reperfusion of the graft liver, from 66.1 ± 14.2 to 108.4 ± 38.1 pg/ml (P < 0.05). This study shows that in dogs with ketamine anesthesia mild hypoglycemia occurs during the anhepatic stage of liver transplantation without exogenous glucose administration followed by hyperglycemia on reperfusion of the graft liver, possibly secondary to the release of glucose from the donor liver

The model of particle production by strong external sources

Using some knowledge of multiplicity disributions for high energy reactions, it is possible to propose a simple analytical model of particle production by strong external sources. The model describes qualitatively most peculiar properties of the distributions. The generating function of the distribution varies so drastically as it can happen at phase transitions.Comment: 7 pages, no Figures, LATEX; Eq. (10) corrected, Eqs (25), (26) added, ref [20] corrected; Pisma v Zhetf 84, n5 (2006

Critical Behavior of Hadronic Fluctuations and the Effect of Final-State Randomization

The critical behaviors of quark-hadron phase transition are explored by use of the Ising model adapted for hadron production. Various measures involving the fluctuations of the produced hadrons in bins of various sizes are examined with the aim of quantifying the clustering properties that are universal features of all critical phenomena. Some of the measures involve wavelet analysis. Two of the measures are found to exhibit the canonical power-law behavior near the critical temperature. The effect of final-state randomization is studied by requiring the produced particles to take random walks in the transverse plane. It is demonstrated that for the measures considered the dependence on the randomization process is weak. Since temperature is not a directly measurable variable, the average hadronic density of a portion of each event is used as the control variable that is measurable. The event-to-event fluctuations are taken into account in the study of the dependence of the chosen measures on that control variable. Phenomenologically verifiable critical behaviors are found and are proposed for use as a signature of quark-hadron phase transition in relativistic heavy-ion collisions.Comment: 17 pages (Latex) + 24 figures (ps file), submitted to Phys. Rev.

Universal behavior of multiplicity differences in quark-hadron phase transition

The scaling behavior of factorial moments of the differences in multiplicities between well separated bins in heavy-ion collisions is proposed as a probe of quark-hadron phase transition. The method takes into account some of the physical features of nuclear collisions that cause some difficulty in the application of the usual method. It is shown in the Ginzburg-Landau theory that a numerical value $\gamma$ of the scaling exponent can be determined independent of the parameters in the problem. The universality of $\gamma$ characterizes quark-hadron phase transition, and can be tested directly by appropriately analyzed data.Comment: 15 pages, including 4 figures (in epsf file), Latex, submitted to Phys. Rev.

Separating Agent-Functioning and Inter-Agent Coordination by Activated Modules: The DECOMAS Architecture

The embedding of self-organizing inter-agent processes in distributed software applications enables the decentralized coordination system elements, solely based on concerted, localized interactions. The separation and encapsulation of the activities that are conceptually related to the coordination, is a crucial concern for systematic development practices in order to prepare the reuse and systematic integration of coordination processes in software systems. Here, we discuss a programming model that is based on the externalization of processes prescriptions and their embedding in Multi-Agent Systems (MAS). One fundamental design concern for a corresponding execution middleware is the minimal-invasive augmentation of the activities that affect coordination. This design challenge is approached by the activation of agent modules. Modules are converted to software elements that reason about and modify their host agent. We discuss and formalize this extension within the context of a generic coordination architecture and exemplify the proposed programming model with the decentralized management of (web) service infrastructures

Self-Similarity of the Negative Binomial Multiplicity Distributions

The negative binomial distribution is self similar: If the spectrum over the whole rapidity range gives rise to a negative binomial, in absence of correlation and if the source is unique, also a partial range in rapidity gives rise to the same distribution. The property is not seen in experimental data, which are rather consistent with the presence of a number of independent sources. When multiplicities are very large self similarity might be used to isolate individual sources is a complex production process.Comment: 10 pages, plane tex, no figure

Modified Gravity on the Brane and Dark Energy

We analyze the dynamics of an AdS5 braneworld with matter fields when gravity is allowed to deviate from the Einstein form on the brane. We consider exact 5-dimensional warped solutions which are associated with conformal bulk fields of weight -4 and describe on the brane the following three dynamics: those of inhomogeneous dust, of generalized dark radiation, and of homogeneous polytropic dark energy. We show that, with modified gravity on the brane, the existence of such dynamical geometries requires the presence of non-conformal matter fields confined to the brane.Comment: Revised version published in Gen. Rel. Grav. Typos corrected, updated reference and some remarks added for clarity. 11 pages, latex, no figure

Improving stamina and mobility with preop walking in surgical patients with frailty traits -OASIS IV: randomized clinical trial study protocol

BACKGROUND: Frail older surgical patients face more than a two-fold increase in postoperative complications, including myocardial infarction, deep vein thrombosis, pulmonary embolism, pneumonia, ileus, and others. Many of these complications occur because of postoperative loss of stamina and poor mobility. Preoperative exercise may better prepare these vulnerable patients for surgery. We present the protocol for our ongoing randomized trial to assess the impact of a preoperative walking intervention with remote coaching and pedometer on outcomes of stamina (six-minute walk distance- 6MWD) and mobility (postoperative steps) in older adults with frailty traits. METHODS: We will be conducting a randomized clinical trial with a total of 120 patients permitting up to a 33% rate of attrition, to reach a final sample size of 80 (with 40 patients for each study arm). We will include patients who are age 60 or higher, score 4 or greater on the Edmonton Frailty Scale assessment, and will be undergoing a surgical operation that requires a 2 or more night hospital stay to be eligible for our trial. Using block randomization stratified on baseline 6MWD, we will assign patients to wear a pedometer. At the end of three baseline days, an athletic trainer (AT) will provide a daily step count goal reflecting a 10-20% increase from baseline. Subsequently, the AT will call weekly to further titrate the goal or calls more frequently if the patient is not meeting the prescribed goal. Controls will receive general walking advice. Our main outcome is change in 6MWD on postoperative day (POD) 2/3 vs. baseline. We will also collect 6MWD approximately 4 weeks after surgery and daily in-hospital steps. CONCLUSION: If changes in a 6MWD and step counts are significantly higher for the intervention group, we believe this will confirm our hypothesis that the intervention leads to decreased loss of stamina and mobility. Once confirmed, we anticipate expanding to multiple centers to assess the interventional impact on clinical endpoints. TRIAL REGISTRATION: The randomized clinical trial was registered on clinicaltrials.gov under the identifier NCT03892187 on March 27, 2019