Galaxy rotation curves from General Relativity with Renormalization Group corrections

We consider the application of quantum corrections computed using renormalization group arguments in the astrophysical domain and show that, for the most natural interpretation of the renormalization group scale parameter, a gravitational coupling parameter $G$ varying $10^{-7}$ of its value across a galaxy (which is roughly a variation of $10^{-12}$ per light-year) is sufficient to generate galaxy rotation curves in agreement with the observations. The quality of the resulting fit is similar to the Isothermal profile quality once both the shape of the rotation curve and the mass-to-light ratios are considered for evaluation. In order to perform the analysis, we use recent high quality data from nine regular disk galaxies. For the sake of comparison, the same set of data is modeled also for the Modified Newtonian Dynamics (MOND) and for the recently proposed Scalar Tensor Vector Gravity (STVG). At face value, the model based on quantum corrections clearly leads to better fits than these two alternative theories.Comment: 35 pages, 12 PDF figures. v4: Version accepted in JCAP. Improved comments on the galactic gas effects to our model, stressed the relevance of our MOND and STVG fits, slightly extended discussion on our perspectives and minor additional comments. Ref's added

Modified gravity models and the central cusp of dark matter haloes in galaxies

The N-body dark matter (DM) simulations point that DM density profiles, e.g. the Navarro Frenk White (NFW) halo, should be cuspy in its centre, but observations disfavour this kind of DM profile. Here we consider whether the observed rotation curves close to the galactic centre can favour modified gravity models in comparison to the NFW halo, and how to quantify such difference. Two explicit modified gravity models are considered, Modified Newtonian Dynamics (MOND) and a more recent approach renormalization group effects in general relativity (RGGR). It is also the purpose of this work to significantly extend the sample on which RGGR has been tested in comparison to other approaches. By analysing 62 galaxies from five samples, we find that (i) there is a radius, given by half the disc scale length, below which RGGR and MOND can match the data about as well or better than NFW, albeit the formers have fewer free parameters; (ii) considering the complete rotation curve data, RGGR could achieve fits with better agreement than MOND, and almost as good as a NFW halo with two free parameters (NFW and RGGR have, respectively, two and one more free parameters than MOND)

Disk and elliptical galaxies within renormalization group improved gravity

The paper is about possible effects of infrared quantum contributions to General Relativity on disk and elliptical galaxies. The Renormalization Group corrected General Relativity (RGGR model) is used to parametrize these quantum effects. The new RGGR results presented here concern the elliptical galaxy NGC 4374 and the dwarf disk galaxy DDO 47. Using the effective approach to Quantum Field Theory in curved background, one can argue that the proper RG energy scale, in the weak field limit, should be related to the Newtonian potential. In the context of galaxies, this led to a remarkably small variation of the gravitational coupling G, while also capable of generating galaxy rotation and dispersion curves of similar quality to the the best dark matter profiles (i.e., the profiles that have a core).Comment: 5 pages. This paper is based on a talk given by D.C. Rodrigues at the I CosmoSul meeting (Rio de Janeiro, RJ - Brazil. August, 01-05, 2011). To be published in AIP conference Proceeding

Renormalization Group approach to Gravity: the running of G and L inside galaxies and additional details on the elliptical NGC 4494

We explore the phenomenology of nontrivial quantum effects on low-energy gravity. These effects come from the running of the gravitational coupling parameter G and the cosmological constant L in the Einstein-Hilbert action, as induced by the Renormalization Group (RG). The Renormalization Group corrected General Relativity (RGGR model) is used to parametrize these quantum effects, and it is assumed that the dominant dark matter-like effects inside galaxies is due to these nontrivial RG effects. Here we present additional details on the RGGR model application, in particular on the Poisson equation extension that defines the effective potential, also we re-analyse the ordinary elliptical galaxy NGC 4494 using a slightly different model for its baryonic contribution, and explicit solutions are presented for the running of G and L. The values of the NGC 4494 parameters as shown here have a better agreement with the general RGGR picture for galaxies, and suggest a larger radial anisotropy than the previously published result.Comment: 9 pages, 2 figs. Based on a talk presented at the VIII International Workshop on the Dark Side of the Universe, June 10-15, 2012, Buzios, RJ, Brazil. v2: typos removed, matches published versio

Anisotropic Cosmological Constant and the CMB Quadrupole Anomaly

There are evidences that the cosmic microwave background (CMB) large-angle anomalies imply a departure from statistical isotropy and hence from the standard cosmological model. We propose a LCDM model extension whose dark energy component preserves its nondynamical character but wield anisotropic vacuum pressure. Exact solutions for the cosmological scale factors are presented, upper bounds for the deformation parameter are evaluated and its value is estimated considering the elliptical universe proposal to solve the quadrupole anomaly. This model can be constructed from a Bianchi I cosmology with cosmological constant from two different ways: i) a straightforward anisotropic modification of the vacuum pressure consistently with energy-momentum conservation; ii) a Poisson structure deformation between canonical momenta such that the dynamics remain invariant under scale factors rescalings.Comment: 8 pages, 2 columns, 1 figure. v2: figure improved, added comments on higher eccentricity powers and references. v3: typos corrected, version to appear in PR

Incidence of mild cognitive impairment and dementia in Parkinson's disease: The Parkinson's disease cognitive impairment study

Background: Cognitive impairment in Parkinson's disease (PD) includes a spectrum varying from Mild Cognitive Impairment (PD-MCI) to PD Dementia (PDD). The main aim of the present study is to evaluate the incidence of PD-MCI, its rate of progression to dementia, and to identify demographic and clinical characteristics which predict cognitive impairment in PD patients. Methods: PD patients from a large hospital-based cohort who underwent at least two comprehensive neuropsychological evaluations were retrospectively enrolled in the study. PD-MCI and PDD were diagnosed according to the Movement Disorder Society criteria. Incidence rates of PD-MCI and PDD were estimated. Clinical and demographic factors predicting PD-MCI and dementia were evaluated using Cox proportional hazard model. Results: Out of 139 enrolled PD patients, 84 were classified with normal cognition (PD-NC), while 55 (39.6%) fulfilled the diagnosis of PD-MCI at baseline. At follow-up (mean follow-up 23.5 ± 10.3 months) 28 (33.3%) of the 84 PD-NC at baseline developed MCI and 4 (4.8%) converted to PDD. The incidence rate of PD-MCI was 184.0/1000 pyar (95% CI 124.7-262.3). At multivariate analysis a negative association between education and MCI development at follow-up was observed (HR 0.37, 95% CI 0.15-0.89; p = 0.03). The incidence rate of dementia was 24.3/1000 pyar (95% CI 7.7-58.5). Out of 55 PD-MCI patients at baseline, 14 (25.4%) converted to PDD, giving an incidence rate of 123.5/1000 pyar (95% CI 70.3-202.2). A five time increased risk of PDD was found in PD patients with MCI at baseline (RR 5.09, 95% CI 1.60-21.4). Conclusion: Our study supports the relevant role of PD-MCI in predicting PDD and underlines the importance of education in reducing the risk of cognitive impairment

Cardiovascular autonomic function and MCI in Parkinson's disease

Introduction: dysautonomic dysfunction and cognitive impairment represent the most disabling non-motor features of Parkinson's Disease (PD). Recent evidences suggest the association between Orthostatic Hypotension (OH) and PD-Dementia. However, little is known on the interactions between cardiovascular dysautonomia and Mild Cognitive Impairment (MCI). We aimed to evaluate the association between cardiovascular dysautonomia and MCI in patients with PD. Methods: non-demented PD patients belonging to the PACOS cohort underwent a comprehensive instrumental neurovegetative assessment including the study of both parasympathetic and sympathetic function (30:15 ratio, Expiratory-Inspiratory ratio [E-I] and presence of Orthostatic Hypotension [OH]). Diagnosis of MCI was made according to the MDS criteria level II. Results: we enrolled 185 PD patients of whom 102 (55.1%) were men, mean age was 64.6 ± 9.7 years, mean disease duration of 5.6 ± 5.5 years with a mean UPDRS-ME score of 31.7 ± 10.9. MCI was diagnosed in 79 (42.7%) patients. OH was recorded in 52 (28.1%) patients, altered 30:15 ratio was recorded in 39 (24.1%) patients and an altered E-I ratio was found in 24 (19.1%) patients. Presence of MCI was associated with an altered 30:15 ratio (adjOR 2.83; 95%CI 1.25–6.40) but not with an altered E-I ratio, while OH was associated only with the amnestic MCI subgroup (OR 2.43; 95% CI 1.05–5.06). Conclusion: in our study sample, MCI was mainly associated with parasympathetic dysfunction in PD

Android application collusion demystified

Application collusion is an emerging threat to Android based devices. In app collusion, two or more apps collude in some manner to perform a malicious action that they are unable to do independently. Detection of colluding apps is a challenging task. Existing commercial malware detection systems analyse each app separately, hence fail to detect any joint malicious action performed by multiple apps through collusion. In this paper, we discuss the current state of research on app collusion and open challenges to the detection of colluding apps. We compare existing approaches and present an integrated approach to effectively detect app collusion

Quantitative Proteomic Analysis Reveals Unique HSP90 Cycle-Dependent Client Interactions

Hsp90 is an abundant and essential molecular chaperone that mediates the folding and activation of client proteins in a nucleotide-dependent cycle. Hsp90 inhibition directly or indirectly impacts the function of 10-15% of all proteins due to degradation of client proteins or indirect downstream effects. Due to its role in chaperoning oncogenic proteins, Hsp90 is an important drug target. However, compounds that occupy the ATP-binding pocket and broadly inhibit function have not achieved widespread use due to negative effects. More selective inhibitors are needed; however, it is unclear how to achieve selective inhibition. We conducted a quantitative proteomic analysis of soluble proteins in yeast strains expressing wild-type Hsp90 or mutants that disrupt different steps in the client folding pathway. Out of 2,482 proteins in our sample set (approximately 38% of yeast proteins), we observed statistically significant changes in abundance of 350 (14%) of those proteins (log2 fold change ≥ 1.5). Of these, 257/350 (∼73%) with the strongest differences in abundance were previously connected to Hsp90 function. Principal component analysis of the entire dataset revealed that the effects of the mutants could be separated into 3 primary clusters. As evidence that Hsp90 mutants affect different pools of clients, simultaneous co-expression of 2 mutants in different clusters restored wild-type growth. Our data suggest that the ability of Hsp90 to sample a wide range of conformations allows the chaperone to mediate folding of a broad array of clients and that disruption of conformational flexibility results in client defects dependent on those states