12 research outputs found
Iso- and glycoforms of the scavenger receptor cysteine-rich protein gp340 with differential bacterial aggregation activity
High DMBT1 concentrations in breast milk correlate with increased risk of infection in preterm and term neonates
Oral Microbiota in Infants Fed a Formula Supplemented with Bovine Milk Fat Globule Membranes - A Randomized Controlled Trial
Instantaneous Effects of Sediment Resuspension on Inorganic and Organic Benthic Nutrient Fluxes at a Shallow Water Coastal Site in the Gulf of Finland, Baltic Sea
Social differences in diagnosed depression among adolescents in a Swedish population based cohort
Oral microbiome development during childhood : an ecological succession influenced by postnatal factors and associated with tooth decay
Information on how the oral microbiome develops during early childhood and how external factors influence this ecological process is scarce. We used high-throughput sequencing to characterize bacterial composition in saliva samples collected at 3, 6, 12, 24 months and 7 years of age in 90 longitudinally followed children, for whom clinical, dietary and health data were collected. Bacterial composition patterns changed through time, starting with “early colonizers”, including Streptococcus and Veillonella; other bacterial genera such as Neisseria settled after 1 or 2 years of age. Dental caries development was associated with diverging microbial composition through time. Streptococcus cristatus appeared to be associated with increased risk of developing tooth decay and its role as potential biomarker of the disease should be studied with species-specific probes. Infants born by C-section had initially skewed bacterial content compared with vaginally delivered infants, but this was recovered with age. Shorter breastfeeding habits and antibiotic treatment during the first 2 years of age were associated with a distinct bacterial composition at later age. The findings presented describe oral microbiota development as an ecological succession where altered colonization pattern during the first year of life may have long-term consequences for child's oral and systemic health.