Application of an Ionic Liquid Column to the Analysis of Flavor and Fragrance Ingredients

Traditional, polar (polyethylene glycol/wax) stationary phase gas chromatography columns pose challenges for flavor and fragrance analysis particularly in regards to thermal instability at high temperatures, degradation when exposed to water, unchanging selectivity, and relatively short shelf lives. Recently, capillary columns using ionic liquids as stationary phases have become available. Ionic liquid columns offer a potential combination of high polarity and high temperature stability with unique selectivity. An in depth discussion about the history and development of column phase characterization, with specific emphasis on selectivity and polarity, will allow for a critical look at the polarity scale currently employed to characterize ionic liquid stationary phases. Performance of an SLB-IL60 column was compared to a traditional HP-20M wax column, with focus on classic thermodynamic parameters – Gibbs free energy, enthalpy, and entropy. This comparison explores retention mechanisms and thermodynamic properties of the ionic liquid stationary phase versus its historical (wax) counterpart. A thorough analysis of these fundamental chemistry parameters developed a strong foundation for a comparison of selectivity and polarity. Ionic liquid columns were found to have similar retention mechanisms for homologous series of primary alcohols and ethyl esters. Thermodynamics revealed differences for homologous series of alkyl aldehydes, alkyl carboxylic acids, and alkanes in regards to retention mechanisms on the SLB-IL60 and HP-20M columns. In addition, a new polyol extraction technique was employed for the extraction of mead (an alcoholic beverage consisting of fermented honey). This extract was compared on both stationary phases to a traditional liquid/liquid extract of the mead. Comparing the activity of flavor and fragrance compounds on ionic liquid and wax stationary phases demonstrated the applicability of ionic liquid columns to the flavor and fragrance industry

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important

Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central nervous system (CNS). Migraine, a largely unknown pathology, is strictly related to the glutamate system in the CNS pathologic terms. Despite the large number of studies conducted on migraine etio-pathology, the kynurenine pathway has been only recently linked to this disease. Nonetheless, some evidence suggests an intriguing role for some kynurenines, and an exploratory study on the serum kynurenine level might be helpful to better understand possible alterations of the kynurenine pathway in patients suffering from migrain

Deep VLT infrared observations of X-ray Dim Isolated Neutron Stars

X-ray observations have unveiled the existence of a family of radio-quiet Isolated Neutron Stars whose X-ray emission is purely thermal, hence dubbed X-ray Dim Isolated Neutron Stars (XDINSs). While optical observations have allowed to relate the thermal emission to the neutron star cooling and to build the neutron star surface thermal map, IR observations are critical to pinpoint a spectral turnover produced by a so far unseen magnetospheric component, or by the presence of a fallback disk. The detection of such a turnover can provide further evidence of a link between this class of isolated neutron stars and the magnetars, which show a distinctive spectral flattening in the IR. Here we present the deepest IR observations ever of five XDINSs, which we use to constrain a spectral turnover in the IR and the presence of a fallback disk. The data are obtained using the ISAAC instrument at the VLT. For none of our targets it was possible to identify the IR counterpart down to limiting magnitudes H = 21.5 - 22.9. Although these limits are the deepest ever obtained for neutron stars of this class, they are not deep enough to rule out the existence and the nature of a possible spectral flattening in the IR. We also derive, by using disk models, the upper limits on the mass inflow rate in a fallback disk. We find the existence of a putative fallback disk consistent (although not confirmed) with our observations.Comment: 6 pages, 2 figures, accepted by A&A on 26-06-200

Optical emission near a high-impedance mirror

Solid state light emitters rely on metallic contacts with high sheet-conductivity for effective charge injection. Unfortunately, such contacts also support surface plasmon polariton (SPP) excitations that dissipate optical energy into the metal and limit the external quantum efficiency. Here, inspired by the concept of radio-frequency (RF) high-impedance surfaces and their use in conformal antennas we illustrate how electrodes can be nanopatterned to simultaneously provide a high DC electrical conductivity and high-impedance at optical frequencies. Such electrodes do not support SPPs across the visible spectrum and greatly suppress dissipative losses while facilitating a desirable Lambertian emission profile. We verify this concept by studying the emission enhancement and photoluminescence lifetime for a dye emitter layer deposited on the electrodes

Daily variability of Ceres' Albedo detected by means of radial velocities changes of the reflected sunlight

Bright features have been recently discovered by Dawn on Ceres, which extend previous photometric and Space Telescope observations. These features should produce distortions of the line profiles of the reflected solar spectrum and therefore an apparent radial velocity variation modulated by the rotation of the dwarf planet. Here we report on two sequences of observations of Ceres performed in the nights of 31 July, 26-27 August 2015 by means of the high-precision HARPS spectrograph at the 3.6-m La Silla ESO telescope. The observations revealed a quite complex behaviour which likely combines a radial velocity modulation due to the rotation with an amplitude of approx +/- 6 m/s and an unexpected diurnal effect. The latter changes imply changes in the albedo of Occator's bright features due to the blaze produced by the exposure to solar radiation. The short-term variability of Ceres' albedo is on timescales ranging from hours to months and can both be confirmed and followed by means of dedicated radial velocity observations.Comment: 5 pag, 1fig, two tables, MNRAS Letters 201

The Halloween effect in European sectors

We present economically and statistically empirical evidence that the Halloween effect is significant. A trading strategy based on this anomaly works persistently and outperforms the buy and hold strategy in 8 out of 10 indices in our sample. We present evidence that the Halloween strategy works two out of every three calendar years and if an investor followed it “blindly”, it would yield an annual average excess of return of approximately 2.4%, compared to the buy and hold strategy and further ensure a significant reduction in risk in all indices (around 7.5% on an annual basis). We have considered several possible explanations for the anomaly, however, none was able to fully justify the seasonal effect. We suggest that a possible explanation may be related to negative average returns during the May–October period, rather than superior performance during the November–April period.info:eu-repo/semantics/acceptedVersio

Isotope Spectroscopy

The measurement of isotopic ratios provides a privileged insight both into nucleosynthesis and into the mechanisms operating in stellar envelopes, such as gravitational settling. In this article, we give a few examples of how isotopic ratios can be determined from high-resolution, high-quality stellar spectra. We consider examples of the lightest elements, H and He, for which the isotopic shifts are very large and easily measurable, and examples of heavier elements for which the determination of isotopic ratios is more difficult. The presence of 6Li in the stellar atmospheres causes a subtle extra depression in the red wing of the 7Li 670.7 nm doublet which can only be detected in spectra of the highest quality. But even with the best spectra, the derived $^6$Li abundance can only be as good as the synthetic spectra used for their interpretation. It is now known that 3D non-LTE modelling of the lithium spectral line profiles is necessary to account properly for the intrinsic line asymmetry, which is produced by convective flows in the atmospheres of cool stars, and can mimic the presence of 6Li. We also discuss briefly the case of the carbon isotopic ratio in metal-poor stars, and provide a new determination of the nickel isotopic ratios in the solar atmosphere.Comment: AIP Thinkshop 10 "High resolution optical spectroscopy", invited talk, AN in pres

A two years open-label prospective study of OnabotulinumtoxinA 195 U in medication overuse headache. a real-world experience

BACKGROUND: The efficacy and safety of OnabotulinumtoxinA (BOTOX®) in adults with chronic migraine (CM) were demonstrated in the PREEMPT program. However, the dosage used in this study was flexible from 155 U to 195 U at the physician's discretion. Therefore, the objective of this prospective study was to compare the efficacy and safety of OnabotulinumtoxinA 195 U vs. 155 U for the treatment of CM and medication overuse headache (MOH) during a 2-year period. METHODS: We prospectively evaluated the mean reduction in headache days, migraine days, acute pain medication intake days and Headache Impact Test (HIT)-6 score in 172 patients injected with OnabotulinumtoxinA 195 U. Successively, we compared the efficacy measures with data of 155 patients injected with OnabotulinumtoxinA 155 U and followed up for 2 years. All patients were affected by CM and MOH, and failed one or more previous detoxification and preventative therapies. RESULTS: Both OnabotulinumtoxinA 195 U and 155 U reduced significantly the number of headache and migraine days, acute pain medication intake days and HIT-6 score, when compared with the baseline measures. Nevertheless, OnabotulinumtoxinA 195 U proved to be superior of 155 U in all efficacy measures since the first injection and for all the 2 years of treatment, with the exception of the reduction in pain medication intake days that resulted significantly larger with 195 U only after the 4th injection. The safety and tolerability of the two doses were similar and treatment related adverse events were transient and mild-moderate. CONCLUSIONS: This study represents the largest and longest post-marketing studies of doses comparison with OnabotulinumtoxinA in a real-life clinical setting. Here, we demonstrate the superior efficacy of OnabotulinumtoxinA 195 U compared to 155 U in CM patients with MOH during a 2-year treatment period with similar safety and tolerability profile