An unexpected complication of a percutaneous coronary angioplasty

Takotsubo cardiomyopathy (TCM) is characterized by transient ventricular dysfunction, classically in its apical and mid segments in the absence of coronary lesions, and is often observed after intense stressful events and occasionally associated to an acute medical illness. We describe a case of TCM associated with coronary artery disease and triggered by a percutaneous coronary angioplasty. This case highlights the concept that a medical procedure can lead, in certain conditions, to TCM and provides new interesting insights on the pathophysiology of coronary syndromes

VGF changes during the estrous cycle: a novel endocrine role for TLQP peptides?

Although the VGF derived peptide TLQP-21 stimulates gonadotropin-releasing hormone (GnRH) and gonadotropin secretion, available data on VGF peptides and reproduction are limited. We used antibodies specific for the two ends of the VGF precursor, and for two VGF derived peptides namely TLQP and PGH, to be used in immunohistochemistry and enzyme-linked immunosorbent assay complemented with gel chromatography. In cycling female rats, VGF C-/N-terminus and PGH peptide antibodies selectively labelled neurones containing either GnRH, or kisspeptin (VGF N-terminus only), pituitary gonadotrophs and lactotrophs, or oocytes (PGH peptides only). Conversely, TLQP peptides were restricted to somatostatin neurones, gonadotrophs, and ovarian granulosa, interstitial and theca cells. TLQP levels were highest, especially in plasma and ovary, with several molecular forms shown in chromatography including one compatible with TLQP-21. Among the cycle phases, TLQP levels were higher during metestrus-diestrus in median eminence and pituitary, while increased in the ovary and decreased in plasma during proestrus. VGF N- and C-terminus peptides also showed modulations over the estrous cycle, in median eminence, pituitary and plasma, while PGH peptides did not. In ovariectomised rats, plasmatic TLQP peptide levels showed distinct reduction suggestive of a major origin from the ovary, while the estrogen-progesterone treatment modulated VGF C-terminus and TLQP peptides in the hypothalamus-pituitary complex. In in vitro hypothalamus, TLQP-21 stimulated release of growth hormone releasing hormone but not of somatostatin. In conclusion, various VGF peptides may regulate the hypothalamus-pituitary complex via specific neuroendocrine mechanisms while TLQP peptides may act at further, multiple levels via endocrine mechanisms involving the ovary

Streaming From a Moving Platform with Real-Time and Playback Distortion Constraints

Video streaming from remotely controlled moving platforms such as drones have stringent constraints in terms of delay. In some applications such videos have to provide real-time visual feedback to the pilot with an acceptable distortion while satisfying high-quality requirements at playback. Furthermore the output rate of the source encoder required to achieve a target distortion depends on the speed of the platform. Motivated by this, we consider a novel source model which takes the source speed into account and derive its rate-distortion region. A transmission strategy based on successive joint encoding, which efficiently takes the source correlation into account, is then considered for transmission over a block fading channel. Our numerical results show that such scheme largely enhances over an independent coding scheme in terms of on-line distortion while approaching the playback distortion performance of an optimal encoder as the group of pictures size grows

Blockchain and self sovereign identity to support quality in the food supply chain

This work presents how a digital identity management system can support food supply chains in guaranteeing the quality of the products marketed and the compliance of the several supplychain’s nodes to standards and technical regulations. Specific goal of this work is to present a system that provides full visibility of process/food certifications, which nowadays are issued by accredited and approved certification bodies (issuers) and delivered and stored in paper version by the several participants (holders) of the supply chain. The system is designed and implemented by combining the latest most innovative and disruptive technologies in the market—Self Sovereign Identity system, Blockchain, and Inter Planetary File System. The crucial aspects that it aims to hit are the storage and access of food/process certifications, and the proper eligibility verification of these certifications exploiting the concepts of the Self Sovereign Identity-based models. The proposed system, realized by using standards that are WWW Consortium-compatible and the Ethereum Blockchain, ensures eligibility, transparency, and traceability of the certifications along a food supply chain, and could be an innovation model/idea that the companies that adopt the Open Innovation paradigm might want to pursue

A System Proposal for Information Management in Building Sector Based on BIM, SSI, IoT and Blockchain

This work presents a Self Sovereign Identity based system proposal to show how Blockchain, Building Information Modeling, Internet of Thing devices, and Self Sovereign Identity concepts can support the process of building digitalization, guaranteeing the compliance standards and technical regulations. The proposal ensures eligibility, transparency and traceability of all information produced by stakeholders, or generated by IoT devices appropriately placed, during the entire life cycle of a building artifact. By exploiting the concepts of the Self Sovereign Identity, our proposal allows the identification of all involved stakeholders, the storage off-chain of all information, and that on-chain of the sole data necessary for the information notarization and certification, adopting multi-signature approval mechanisms where appropriate. In addition it allows the eligibility verification of the certificated information, providing also useful information for facility management. It is proposed as an innovative system and companies that adopt the Open Innovation paradigm might want to pursue it. The model proposal is designed exploiting the Veramo platform, hence the Ethereum Blockchain, and all the recommendations about Self Sovereign Identity systems given by the European Blockchain Partnership, and by the World Wide Web Consortium

Bitcoin as Safe Haven during Covid-19 Disease

In this paper, we investigate the role of Bitcoin as a safe haven against the stock market losses during the spread of COVID-19. The performed analysis was based on a regression model with dummy variables defined around some crucial dates of the pandemic and on the dynamic conditional correlations. To try to model the real dynamics of the markets, we studied the safe-haven properties of Bitcoin against thirteen of the major stock market indexes losses using daily data spanning from 1 July 2019 until 20 February 2021. A similar analysis was also performed for Ether. Results show that this pandemic impacts on the Bitcoin status as safe haven, but we are still far from being able to define Bitcoin as a safe haven

GRB Observed by IBIS/PICsIT in the MeV Energy Range

We present the preliminary results of a systematic search for GRB and other transients in the publicly available data for the IBIS/PICsIT (0.2-10 MeV) detector on board INTEGRAL. Lightcurves in 2-8 energy bands with time resolution from 1 to 62.5 ms have been collected and an analysis of spectral and temporal characteristics has been performed. This is the nucleus of a forthcoming first catalog of GRB observed by PICsIT.Comment: 6 pages, 3 figures. Poster presented at COSPAR 2008. Advaces in Space Research, accepted for publicatio