Adverse Drug Reactions in Children—A Systematic Review

Adverse drug reactions in children are an important public health problem. We have undertaken a systematic review of observational studies in children in three settings: causing admission to hospital, occurring during hospital stay and occurring in the community. We were particularly interested in understanding how ADRs might be better detected, assessed and avoided

Reações adversas a medicamentos em pediatria: uma revisão sistemática de estudos prospectivos Adverse drug reactions in pediatrics: a systematic review of prospective studies

O objetivo desta revisão foi explorar e comparar as informações derivadas de estudos prospectivos sobre a incidência de reações adversas a medicamentos (RAM) em pediatria, publicados de janeiro de 1966 a novembro de 2003 em revistas indexadas nas bases MEDLINE, IPA e LILACS. Foram buscados trabalhos que abordassem a ocorrência de RAM em crianças atendidas em ambulatório, durante a hospitalização ou como causa de internação hospitalar não focalizados em tratamentos ou condições clínicas específicas. A análise incluiu vinte estudos de coorte prospectivos, entre os quais a incidência de RAM variou de 0,75% a 11,1% em ambulatório, de 0,6 a 4,3% como causa de internação hospitalar e de 4,4 a 18,1% entre crianças hospitalizadas. O trabalho ressalta o potencial de contribuição dos estudos prospectivos para o uso seguro de medicamentos em pediatria e sugere que a padronização de definições e de critérios metodológicos poderia torná-los mais úteis para esse objetivo.<br>The aim of this literature review is to explore and to compare information derived from prospective studies of adverse drug reactions (ADR) incidence in pediatrics. A systematic literature research was performed looking for studies involving outpatient and inpatient children as well hospitalizations due to ADR. The studies were identified in MEDLINE, IPA and LILACS databases from January 1966 to November 2003. Investigation focused on specific treatments or morbidities was not included in the review. Twenty prospective cohort studies were included in the analysis. In outpatient investigations ADR incidence varied from 0.75% to 11.1% between the studies; 0.6% to 4.3% of hospital admissions were related to ADR with ADR frequency during hospitalization varying from 4.4% to 18.1% of the children. The lack of definition standards and of methodological criteria hindered results comparison and could partly explain the different observations

Out of the communist frying pan and into the EU fire? Exploring the case of Kashubian

A language currently at the nexus of change is Kashubian (in Polish: kaszubski), a West Slavic language spoken in northern Poland in the province of Pomerania. Termed a 'regional language' by the Polish government in preparation for the ratification of the European Charter for Regional or Minority Languages (signed in 2003 and ratified in 2008), it presents interesting parallels with other minority languages at different phases, in terms of its weak economic status and a history of repression. The impact of Poland's accession to the EU in 2004 and the Polish government's recent revitalisation initiatives will be explored. The views of three prominent Kashubian activists are considered as they reflect on the past, present and future of Kashubian. Issues considered include the changing status of Kashubian and the impact of such change on identity, the role of Catholicism in supporting Kashubian and the need for development in the spheres of literature and education. Of particular interest is a consideration of the effect on the language's visibility and status as a result of having a Kashub, Donald Tusk, become Prime Minister in October 2007, following decades of neglect and denial of Kashubian's status as a language under Communism, and he is one of those interviewed here.                     AD 28/01/201