5,660 research outputs found

    Synthetic Approaches to 2-Substituted 4-Hydroxypiperidines

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    Aquatic Invasive Species as Hazards on Water Resources and Ecosystems in Texas

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    Water losses due to invasive species cost Texas hundreds of thousands of acre feet of water per year, water unavailable for instream flows, irrigation and other human uses. Innovative, proactive ecological research and public and policy awareness and education initiatives are instrumental to preventing further invasions and managing existing exotic species impacts in Texas aquatic ecosystems

    A New Social Contract for the American Workplace: From Paternalism to Partnering

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    As American business struggles to cope with global competition, technological breakthroughs, and various forms of deregulation, the workplace is being thrown into turmoil. Against this backdrop, 1994 is also on pace to set a record for publicly announced downsizings, most of them justified under the banner of restructuring. This study is the first comprehensive look at this evolving picture.https://openscholarship.wustl.edu/mlw_papers/1164/thumbnail.jp

    Preliminary operational results from the Willard solar power system

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    The solar powered system located near Willard, New Mexico, generates mechanical or electrical power at a capacity of 19 kW (25 HP). The solar collection system incorporates east/west tracking parabolic trough collectors with a total aperture area of 1275 sq m (13,720 sq ft). The hot oil type thermal energy storage is sufficient for approximately 20 hours of power system operation. The system utilizes a reaction type turbine in conjunction with an organic Rankine cycle engine. Total collector field efficiency reaches a maximum of 20 percent near the winter solstice and about 50 percent during the summer. During the month of July, 1979, the system pumped 60 percent of the 35,300 cu m (28.6 acre-feet) of water delivered. Operating efficiencies for the turbine component, organic Rankine cycle engine and the complete power system are respectively 65 to 75 percent, 12 to 15 percent and 5 to 6 percent. Significant maintenance time was expended on both the collector and power systems throughout the operational period

    Small Business Performance in the Regulated Economy

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    This paper studies the various effects of federal regulation on small business firms.https://openscholarship.wustl.edu/mlw_papers/1186/thumbnail.jp

    Structure of an Aspergillus fumigatus old yellow enzyme (EasA) involved in ergot alkaloid biosynthesis

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    This is the published version.The Aspergillus fumigatus old yellow enzyme (OYE) EasA reduces chanoclavine-I aldehyde to dihydrochanoclavine aldehyde and works in conjunction with festuclavine synthase at the branchpoint for ergot alkaloid pathways. The crystal structure of the FMN-loaded EasA was determined to 1.8 Å resolution. The active-site amino acids of OYE are conserved, supporting a similar mechanism for reduction of the α/β-unsaturated aldehyde. The C-terminal tail of one monomer packs into the active site of a monomer in the next asymmetric unit, which is most likely to be a crystallization artifact and not a mechanism of self-regulation

    Development and validation of a chemostat gut model to study both planktonic and biofilm modes of growth of Clostridium difficile and human microbiota

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    Copyright: 2014 Crowther et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.The human gastrointestinal tract harbours a complex microbial community which exist in planktonic and sessile form. The degree to which composition and function of faecal and mucosal microbiota differ remains unclear. We describe the development and characterisation of an in vitro human gut model, which can be used to facilitate the formation and longitudinal analysis of mature mixed species biofilms. This enables the investigation of the role of biofilms in Clostridium difficile infection (CDI). A well established and validated human gut model of simulated CDI was adapted to incorporate glass rods that create a solid-gaseous-liquid interface for biofilm formation. The continuous chemostat model was inoculated with a pooled human faecal emulsion and controlled to mimic colonic conditions in vivo. Planktonic and sessile bacterial populations were enumerated for up to 46 days. Biofilm consistently formed macroscopic structures on all glass rods over extended periods of time, providing a framework to sample and analyse biofilm structures independently. Whilst variation in biofilm biomass is evident between rods, populations of sessile bacterial groups (log10 cfu/g of biofilm) remain relatively consistent between rods at each sampling point. All bacterial groups enumerated within the planktonic communities were also present within biofilm structures. The planktonic mode of growth of C. difficile and gut microbiota closely reflected observations within the original gut model. However, distinct differences were observed in the behaviour of sessile and planktonic C. difficile populations, with C. difficile spores preferentially persisting within biofilm structures. The redesigned biofilm chemostat model has been validated for reproducible and consistent formation of mixed species intestinal biofilms. This model can be utilised for the analysis of sessile mixed species communities longitudinally, potentially providing information of the role of biofilms in CDI.Peer reviewe

    Earning More, Receiving Less: Loss of Benefits and Child Hunger

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    New research from Children's HealthWatch shows that increases in income that trigger loss of public assistance benefits can leave young children without enough food to eat. Families hat have been cut off from SNAP or TANF when their income exceeds eligibility limits are more likely to experience levels of food insecurity that require reducing the size or frequency of children's meals compared to those currently receiving benefits. Previous research has demonstrated that both SNAP and TANF reduce the likelihood of food insecurity. Income eligibility guidelines should be re-examined to ensure that a modest increase in income does not disqulaify a family from the benefits they need to keep their children healthy and well-fed. Families that successfully increase their earnings should not find themselves worse off due to a resulting loss of benefits

    Children of Immigrants: Healthy Beginnings Derailed by Food Insecurity

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    Children of immigrants are the fastest growing child population in the United States. More than 20 percent of children under age six have immigrant parents; approximately 93 percent of these children are American citizens.Of the children who are non-citizens, two-thirds will grow up to become citizens, playing a critical role in our nation's future
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