Five Steps to a Better U: Improving the Crime-fighting Visa

Congress created the U nonimmigrant status to assist noncitizen vic- tims of serious crime and to encourage them to assist law enforce- ment in the investigation of that crime. Despite these laudable goals, the process has been flawed since the outset. U visas were capped at 10,000 per year, eventually precipitating a multi-year backlog that diminishes the incentive to report crime for persons who fear depor- tation. Of particular importance, the willingness of law enforcement officers to provide a certification of helpfulness—a mandatory com- ponent of an application for U status—varies tremendously across agencies. Eligibility for U status is thus a matter of “geographic rou- lette.” New policies implemented under the Trump Administration threaten this already fraught scheme. In particular, the Department of Homeland Security has reinvigorated cooperative enforcement agreements with state and local police and expanded removal priori- ties to include those merely charged or suspected of criminal activity. These developments mean that undocumented victims of serious crime expose themselves to significant risk of deportation when they involve the police. When crime is unreported, perpetrators may re- main at large, free to offend again. Particularly in domestic violence situations, survivors and their families remain vulnerable to further harm. Ironically, these results conflict with another stated initiative of the Trump Administration: fighting crime. This symposium essay offers five concrete reforms that would ameliorate the problems hampering the effectiveness of the U visa

Measuring diet in primary school children aged 8-11 years: validation of the Child and Diet Evaluation Tool (CADET) with an emphasis on fruit and vegetable intake.

Background/Objectives:The Child And Diet Evaluation Tool (CADET) is a 24-h food diary that measures the nutrition intake of children aged 3-7 years, with a focus on fruit and vegetable consumption. Until now CADET has not been used to measure nutrient intake of children aged 8-11 years. To ensure that newly assigned portion sizes for this older age group were valid, participants were asked to complete the CADET diary (the school and home food diary) concurrently with a 1-day weighed record. Subjects/Methods:A total of 67 children with a mean age of 9.3 years (s.d.: ± 1.4, 51% girls) participated in the study. Total fruit and vegetable intake in grams and other nutrients were extracted to compare the mean intakes from the CADET diary and Weighed record using t-tests and Pearson's r correlations. Bland-Altman analysis was also conducted to assess the agreement between the two methods. Results: Correlations comparing the CADET diary to the weighed record were high for fruit, vegetables and combined fruit and vegetables (r=0.7). The results from the Bland-Altman plots revealed a mean difference of 54 g (95% confidence interval: -88, 152) for combined fruit and vegetables intake. CADET is the only tool recommended by the National Obesity Observatory that has been validated in a UK population and provides nutrient level data on children's diets. Conclusions:The results from this study conclude that CADET can provide high-quality nutrient data suitable for evaluating intervention studies now for children aged 3-11 years with a focus on fruit and vegetable intake

Hairy Leukoplakia

Oral hairy leukoplakia (OHL) is a disease of the mucosa first described in 1984. This pathology is associated with Epstein-Barr virus (EBV) and occurs mostly in people with HIV infection, both immunocompromised and immunocompetent, and can affect patients who are HIV negative. [1, 2] The first case in an HIV-negative patient was reported in 1999 in a 56-year-old patient with acute lymphocytic leukemia. Later, many cases were reported in heart, kidney, and bone marrow transplant recipients and patients with hematological malignancies. [3, 4

Investor behavior and the benefits of direct stock ownership

Whereas prior research emphasizes the monitoring benefits of concentrated stock ownership, we examine a variety of potential benefits of dispersed ownership for public companies. Using a field experiment to rule out reverse causality, we examine whether a small investment in a company’s stock leads investors to purchase more of the company’s products and adopt other views and preferences that benefit the company. We find little evidence consistent with our hypotheses using frequentist statistics, and Bayesian parameter estimation shows substantial downward belief revision for more optimistic ex ante expectations of the treatment effects for the average investor. However, we do find that the effects of ownership on product purchase behavior and on regulatory preferences are intuitively stronger for certain subgroups of investors—namely, for investors who are most likely to consume the types of products offered by the company and for investors who are most likely to be politically active, respectively. The results contribute to our understanding of the benefits of dispersed stock ownership and are informative to public company managers and directors

Meat Consumption, Cognitive Function and Disorders: A Systematic Review with Narrative Synthesis and Meta-Analysis

Cognitive impairment, Alzheimer’s disease, and other forms of dementia are increasing in prevalence worldwide, while global dietary patterns are transitioning to a ‘western type’ with increasing meat consumption. Studies which have explored the associations between cognitive function and meat intakes have produced inconsistent findings. The aim of this systematic review was to explore the evidence linking meat intake with cognitive disorders. Twenty-nine studies were retrieved, including twelve cohort, three case-control, thirteen cross-sectional studies, and one intervention study. The majority (21/29) showed that meat consumption was not significantly associated with cognitive function or disorders. Meta-analysis of five studies showed no significant differences in meat consumption between cases with cognitive disorders and controls (standardized mean difference = −0.32, 95% CI: −1.01, 0.36); however, there was considerable heterogeneity. In contrast, a meta-analysis of five studies showed reduced odds of cognitive disorders by consuming meat weekly or more (OR = 0.73, 95% CI: 0.57, 0.88); however, potential publication bias was noted in relation to this finding. Overall, there was no strong association between meat intake and cognitive disorders. However, the evidence base was limited, requiring more studies of high quality to isolate the specific effect of meat consumption from dietary patterns to confirm these associations

Phosphorus forms and concentrations in soils under different land use in southwestern Saskatchewan

Non-Peer ReviewedPhosphorus (P) is an essential nutrient for all organisms. Insufficient or poorly available P can limit crop growth, requiring P fertilization. However, excess P can move from land to water, impairing water quality. Balancing P fertilization to maximize crop growth while limiting P loss requires a detailed knowledge of P forms and cycling. Different land use practices are expected to alter P cycling through differences in microbial populations, P inputs from vegetation and fertilizer, and management practices that affect soil chemical and physical properties. Understanding P cycling under different land uses can help to improve P use efficiency in agriculture. Presented here are the preliminary results of a research project investigating P forms and cycling in soils under different land uses in southwestern Saskatchewan

Picoliter-volume inkjet printing into planar microdevice reservoirs for low-waste, high-capacity drug loading.

Oral delivery of therapeutics is the preferred route for systemic drug administration due to ease of access and improved patient compliance. However, many therapeutics suffer from low oral bioavailability due to low pH and enzymatic conditions, poor cellular permeability, and low residence time. Microfabrication techniques have been used to create planar, asymmetric microdevices for oral drug delivery to address these limitations. The geometry of these microdevices facilitates prolonged drug exposure with unidirectional release of drug toward gastrointestinal epithelium. While these devices have significantly enhanced drug permeability in vitro and in vivo, loading drug into the micron-scale reservoirs of the devices in a low-waste, high-capacity manner remains challenging. Here, we use picoliter-volume inkjet printing to load topotecan and insulin into planar microdevices efficiently. Following a simple surface functionalization step, drug solution can be spotted into the microdevice reservoir. We show that relatively high capacities of both topotecan and insulin can be loaded into microdevices in a rapid, automated process with little to no drug waste