1,697 research outputs found
Seismic cycles, size of the largest events, and the avalanche size distribution in a model of seismicity
We address several questions on the behavior of a numerical model recently
introduced to study seismic phenomena, that includes relaxation in the plates
as a key ingredient. We make an analysis of the scaling of the largest events
with system size, and show that when parameters are appropriately interpreted,
the typical size of the largest events scale as the system size, without the
necessity to tune any parameter. Secondly, we show that the temporal activity
in the model is inherently non-stationary, and obtain from here justification
and support for the concept of a "seismic cycle" in the temporal evolution of
seismic activity. Finally, we ask for the reasons that make the model display a
realistic value of the decaying exponent in the Gutenberg-Richter law for
the avalanche size distribution. We explain why relaxation induces a systematic
increase of from its value observed in the absence of
relaxation. However, we have not been able to justify the actual robustness of
the model in displaying a consistent value around the experimentally
observed value .Comment: 11 pages, 10 figure
First motions from seismic sources near a free surface
The radiation patterns of first motions are calculated for the sudden occurrence of an arbitrarily oriented fault (dislocation) at the surface of a half space; the dislocation in the fault plane is also arbitrarily oriented and is assumed to occur over a very small area of the fault plane. Initially the source is considered at a finite depth and the solution is obtained by allowing the depth to tend to zero.
In general the results show a surprising directionality for the radiation of SV. In the focal plane projection the first motions of P and SH for a strike-slip fault show the familiar four-lobed radiation patterns. The first motions of SV show some reversals in polarity with angular distance from the source.
The first motions for all components of motion for a dip-slip fault have characteristics governed strongly by the presence of the free surface, and hence differ markedly from the usual radiation patterns for a deeply imbedded source
Network of recurrent events for the Olami-Feder-Christensen model
We numerically study the dynamics of a discrete spring-block model introduced
by Olami, Feder and Christensen (OFC) to mimic earthquakes and investigate to
which extent this simple model is able to reproduce the observed spatiotemporal
clustering of seismicty. Following a recently proposed method to characterize
such clustering by networks of recurrent events [Geophys. Res. Lett. {\bf 33},
L1304, 2006], we find that for synthetic catalogs generated by the OFC model
these networks have many non-trivial statistical properties. This includes
characteristic degree distributions -- very similar to what has been observed
for real seismicity. There are, however, also significant differences between
the OFC model and earthquake catalogs indicating that this simple model is
insufficient to account for certain aspects of the spatiotemporal clustering of
seismicity.Comment: 11 pages, 16 figure
Tube Waves, Seismic Waves And Effective Sources
A simple asymptotic analysis, based on the smallness of the ratio of the borehole radius
to the wavelength, reveals the interaction between tube waves and seismic waves. The
pressure field in a tube wave acts as a secondary source of seismic waves and conversely
an incoming seismic wave excites a tube wave. The asymptotic analysis leads to a
characterization of these sources in terms of the solution to two-dimensional elastostatic problems. These may be solved exactly when the borehole has an elliptical cross-section even in an anisotropic formation. Also the borehole need not be straight provided that its radius of curvature is large compared with a wavelength
Functional Electrical Stimulation mediated by Iterative Learning Control and 3D robotics reduces motor impairment in chronic stroke
Background: Novel stroke rehabilitation techniques that employ electrical stimulation (ES) and robotic technologies are effective in reducing upper limb impairments. ES is most effective when it is applied to support the patients’ voluntary effort; however, current systems fail to fully exploit this connection. This study builds on previous work using advanced ES controllers, and aims to investigate the feasibility of Stimulation Assistance through Iterative Learning (SAIL), a novel upper limb stroke rehabilitation system which utilises robotic support, ES, and voluntary effort. Methods: Five hemiparetic, chronic stroke participants with impaired upper limb function attended 18, 1 hour intervention sessions. Participants completed virtual reality tracking tasks whereby they moved their impaired arm to follow a slowly moving sphere along a specified trajectory. To do this, the participants’ arm was supported by a robot. ES, mediated by advanced iterative learning control (ILC) algorithms, was applied to the triceps and anterior deltoid muscles. Each movement was repeated 6 times and ILC adjusted the amount of stimulation applied on each trial to improve accuracy and maximise voluntary effort. Participants completed clinical assessments (Fugl-Meyer, Action Research Arm Test) at baseline and post-intervention, as well as unassisted tracking tasks at the beginning and end of each intervention session. Data were analysed using t-tests and linear regression. Results: From baseline to post-intervention, Fugl-Meyer scores improved, assisted and unassisted tracking performance improved, and the amount of ES required to assist tracking reduced. Conclusions: The concept of minimising support from ES using ILC algorithms was demonstrated. The positive results are promising with respect to reducing upper limb impairments following stroke, however, a larger study is required to confirm this
THE ROLE OF LITERAL MEANING IN THE COMPREHENSION OF NON-LITERAL CONSTRUCTIONS
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72630/1/j.1467-8640.1992.tb00373.x.pd
Direct Activation of RhoA by Reactive Oxygen Species Requires a Redox-Sensitive Motif
BACKGROUND:Rho family GTPases are critical regulators of the cytoskeleton and affect cell migration, cell-cell adhesion, and cell-matrix adhesion. As with all GTPases, their activity is determined by their guanine nucleotide-bound state. Understanding how Rho proteins are activated and inactivated has largely focused on regulatory proteins such as guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). However, recent in vitro studies have indicated that GTPases may also be directly regulated by redox agents. We hypothesized that this redox-based mechanism occurs in cells and affects cytoskeletal dynamics, and in this report we conclude this is indeed a novel mechanism of regulating the GTPase RhoA. METHODOLOGY/PRINCIPAL FINDINGS:In this report, we show that RhoA can be directly activated by reactive oxygen species (ROS) in cells, and that this requires two critical cysteine residues located in a unique redox-sensitive motif within the phosphoryl binding loop. First, we show that ROS can reversibly activate RhoA and induce stress fiber formation, a well characterized readout of RhoA activity. To determine the role of cysteine residues in this mechanism of regulation, we generated cysteine to alanine RhoA mutants. Mutation of these cysteines abolishes ROS-mediated activation and stress fiber formation, indicating that these residues are critical for redox-regulation of RhoA. Importantly, these mutants maintain the ability to be activated by GEFs. CONCLUSIONS/SIGNIFICANCE:Our findings identify a novel mechanism for the regulation of RhoA in cells by ROS, which is independent of classical regulatory proteins. This mechanism of regulation may be particularly relevant in pathological conditions where ROS are generated and the cellular redox-balance altered, such as in asthma and ischemia-reperfusion injury
The Network of Epicenters of the Olami-Feder-Christensen Model of Earthquakes
We study the dynamics of the Olami-Feder-Christensen (OFC) model of
earthquakes, focusing on the behavior of sequences of epicenters regarded as a
growing complex network. Besides making a detailed and quantitative study of
the effects of the borders (the occurrence of epicenters is dominated by a
strong border effect which does not scale with system size), we examine the
degree distribution and the degree correlation of the graph. We detect sharp
differences between the conservative and nonconservative regimes of the model.
Removing border effects, the conservative regime exhibits a Poisson-like degree
statistics and is uncorrelated, while the nonconservative has a broad
power-law-like distribution of degrees (if the smallest events are ignored),
which reproduces the observed behavior of real earthquakes. In this regime the
graph has also a unusually strong degree correlation among the vertices with
higher degree, which is the result of the existence of temporary attractors for
the dynamics: as the system evolves, the epicenters concentrate increasingly on
fewer sites, exhibiting strong synchronization, but eventually spread again
over the lattice after a series of sufficiently large earthquakes. We propose
an analytical description of the dynamics of this growing network, considering
a Markov process network with hidden variables, which is able to account for
the mentioned properties.Comment: 9 pages, 10 figures. Smaller number of figures, and minor text
corrections and modifications. For version with full resolution images see
http://fig.if.usp.br/~tpeixoto/cond-mat-0602244.pd
Master equation approach to friction at the mesoscale
At the mesoscale friction occurs through the breaking and formation of local
contacts. This is often described by the earthquake-like model which requires
numerical studies. We show that this phenomenon can also be described by a
master equation, which can be solved analytically in some cases and provides an
efficient numerical solution for more general cases. We examine the effect of
temperature and aging of the contacts and discuss the statistical properties of
the contacts for different situations of friction and their implications,
particularly regarding the existence of stick-slip.Comment: To be published in Physical Review
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