Spes Nova

En el presente trabajo se dio continuidad al proyecto del semestre Primavera 2023, con la finalidad de cumplir con el objetivo inicial de apoyar artesanos que se encuentren en situación económica escasa, de manera que se dio seguimiento a la comunicación con los artesanos que anteriormente fueron seleccionados, además de integrar a nuevos prospectos, y mientras se garantizaba el cumplimiento del perfil, los estándares de calidad, tiempos de entrega, así como el interés en la exportación de sus productos. Dichos objetivos se alcanzaron a través de un plan de trabajo establecido desde el inicio del período, donde cada integrante del equipo estuvo a cargo de un tema en específico. Estos temas se conforman de la búsqueda de nuevos artesanos, la comunicación con el artesano con el que se llevó a cabo la primera exportación a Spes Nova, así como la presentación de una propuesta comercial a la Tienda Soy ITESO. Es así, entonces que, al finalizar este proyecto, fue posible identificar más artesanos con el perfil buscado y sumarlos tanto a la propuesta comercial con Spes Nova, como a la Tienda Soy ITESO. Además, se establecieron las pautas para desarrollar una extensión de Spes Nova en México, donde sea posible ampliar la red comercial de los artesanos dentro del mercado mexicano.ITESO, A.C

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life cycle. We have previously reported the discovery of a novel class of antimalarial compounds in the imidazolopiperazine series that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the previously reported activity profile of this series, the clinical candidate KAF156 shows blood schizonticidal activity with 50% inhibitory concentrations of 6 to 17.4 nM against P. falciparum drug-sensitive and drug-resistant strains, as well as potent therapeutic activity in a mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively. When administered prophylactically in a sporozoite challenge mouse model, KAF156 is completely protective as a single oral dose of 10 mg/kg. Finally, KAF156 displays potent Plasmodium transmission blocking activities both in vitro and in vivo. Collectively, our data suggest that KAF156, currently under evaluation in clinical trials, has the potential to treat, prevent, and block the transmission of malaria

Multiplex financial networks: revealing the level of interconnectedness in the banking system

Complex networks models have been useful for the study of systemic risk; however, most of the studies have ignored the true level of interconnectedness in the financial system; in this work we show the missing part on the study of interconnectedness. Furthermore, complexity in modern financial systems has been also an important subject of study. However, we still lack the appropriate metrics to describe such complexity and interconnectedness; moreover, the data available in order to describe and study them is still scarce. In addition, most of the focus on the subject of interconnectedness has been on a single type of network: interbank (exposures) networks. We use a comprehensive set of market interactions that include transactions in the securities markets, payment system flows, interbank loans, cross holding of securities, foreign exchange exposures and derivatives exposures. This the first attempt, to the best of our knowledge, to describe so comprehensively the complexity and interconnectedness in a banking system. We are able to identify the most important institutions in the whole structure in term of their connectedness, the most relevant layer (in structural terms) of the multiplex and the community structure of the Mexican banking system which can be seen as a generalization of the well-known Core-Periphery model