Liquid polymorphism and density anomaly in a three-dimensional associating lattice gas

We investigate the phase diagram of a three-dimensional associating gas $(ALG)$ model. This model combines orientational ice-like interactions and ``van der Waals'' that might be repulsive, representing, in this case, a penalty for distortion of hydrogen bonds. These interactions can be interpreted as two competing distances making the connection between this model and continuous isotropic soft-core potentials. We present Monte Carlo studies of the $ALG$ model showing the presence of two liquid phase, two critical points and A density anomaly

Density anomaly in a competing interactions lattice gas model

We study a very simple model of a short-range attraction and an outer shell repulsion as a test system for demixing phase transition and density anomaly. The phase-diagram is obtained by applying mean field analysis and Monte Carlo simulations to a two dimensional lattice gas with nearest-neighbors attraction and next-nearest-neighbors repulsion (the outer shell). Two liquid phases and density anomaly are found. The coexistence line between these two liquid phases meets a critical line between the fluid and the low density liquid at a tricritical point. The line of maximum density emerges in the vicinity of the tricritical point, close to the demixing transition

The Latin American experience of allografting patients with severe aplastic anaemia: real-world data on the impact of stem cell source and ATG administration in HLA-identical sibling transplants

We studied 298 patients with severe aplastic anaemia (SAA) allografted in four Latin American countries. The source of cells was bone marrow (BM) in 94 patients and PBSCs in 204 patients. Engraftment failed in 8.1% of recipients with no difference between BM and PBSCs (P = 0.08). Incidence of acute GvHD (aGvHD) for BM and PBSCs was 30% vs 32% (P = 0.18), and for grades III–IV was 2.6% vs 11.6% (P = 0.01). Chronic GvHD (cGvHD) between BM and PBSCs was 37% vs 59% (P = 0.002) and extensive 5% vs 23.6% (P = 0.01). OS was 74% vs 76% for BM vs PBSCs (P = 0.95). Event-free survival was superior in patients conditioned with anti-thymocyte globulin (ATG)-based regimens compared with other regimens (79% vs 61%, P = 0.001) as excessive secondary graft failure was seen with other regimens (10% vs 26%, P = 0.005) respectively. In multivariate analysis, aGvHD II–IV (hazard ratio (HR) 2.50, confidence interval (CI) 1.1–5.6, P = 0.02) and aGvHD III–IV (HR 8.3 CI 3.4–20.2, Po0.001) proved to be independent negative predictors of survival. In conclusion, BM as a source of cells and ATG-based regimens should be standard because of higher GvHD incidence with PBSCs, although the latter combining with ATG in the conditioning regimen could be an option in selected high-risk patient

Aspectos Didácticos y Tecnológicos a Considerar para el Desarrollo de Materiales Educativos para Materiales Educativos para Educación Basada en Web

Ponencia del 1er. Foro de Investigación Educativ

Comparative treatment between sitagliptin vs. metformin, alone or in combination, in patients with polycystic ovary syndrome. A clinical entity at high risk for developing diabetes mellitus and gestational diabetes: A pilot study

Objective: To determine the efficacy of sitagliptin alone or in combination with metformin in women with polycystic ovary in terms of ovarian cyclicity, fertility and cardiometabolic profile compared to metformin alone. Rationale: polycystic ovarian syndrome (PCOS) affects a percentage of 5–10% of women of reproductive age worldwide and has a prevalence of 6.6% (95% CI: 2.3–10.9%) in Mexican women and most common cause of infertility in developed countries. Treatment with insulin sensitizing drugs (metformin and pioglitazone) has been shown to improve menstrual cyclicity and fertility in the metabolic profile with polycystic ovarian patients. Incretins and DPP-4 inhibitors have been shown to enhance pancreatic β cell activity, increasing weight loss by its anorexic effect and resulting in an adequate weight control and improved fertility. Previous evidence has compared the effect of exenatide and alone or in combination with metformin in the treatment of PCOS, in this article we will compare sitagliptin and metformin alone or in combination. Study design: Blind, controlled and randomized clinical trial. Patients: Women between 18 and 40 years of age, with a BMI >20 and diagnosed with PCOS with the Rotterdam criteria. Results: In the normalized index of menstruations it was found that there was a statistically significant intragroup increase in each one of the treatments. With a higher percentage of change, that of metformin with 80%, followed by that of sitagliptin with 65% and then COMBO with 30%. No statistically significant differences were found between treatment groups. Conclusion: Therapeutic effect of sitagliptin was observed in patients with PCOS comparable to metformin and the combination of metformin-sitagliptin is more effective in terms of ovulation than the other two treatments alone

Assessment of the living conditions and well-being of DLSHSI student dormers

The study used the descriptive research design involving 434 student dormers from College of Medical Radiation Technology, College of Rehabilitation Sciences, College of Pharmacy, College of Medical Laboratory Science, College of Humanities and Sciences, College of Nursing. A questionnaire was adapted from the research study of Adegue, et al., (2011), entitled “The Living Conditions of College Students in Boarding Houses in Davao, City , Philippines” and for the well-being of students, coming from “The New Philanthropical Capital”. Purposive sampling was used and the statistical measures utilized were frequency, mean, percentage, standard deviation, Mann-Whitney Test and Kruskal-Wallis H Test. Based on the findings of the study, the researchers were able to conclude that: 1) Majority of the respondents were female, came from the College of Rehabilitation Sciences, and from second year level; 2) Most of the facilities, safety and security measures, and utilities were present or existing, but some important features were inexistent such as the: curfew policy, scheduled visitation hours policy, CCTV or closed-circuit television, finger biometric system, logbook, paging system, smoke detectors, fire sprinkler/automatic fire sprinkler system, fire alarm, and emergency lights; 3) The dormitory owners and operators were providing good service quality for the student dormers; 4) The respondents have an overall high level of well-being, however resulted in low emotional well-being during their stay in dormitory; 5) There are no significant differences in the well-being of the respondents when grouped according to college and year level, but have significant differences when grouped according to gender. Female respondents have a lower level of well-being compared to male respondents while living in dormitories