Rotura cuadricipital en edad pediátrica

La rotura del tendón del cuádriceps es una patología característica de la edad adulta, siendo excepcional en la infancia. Se presenta el caso de un niño de 9 años con una gonalgia izquierda de 2 meses de evolución sin claro antecedente traumático. Se realiza Resonancia Magnética, que establece el diagnóstico de rotura parcial del tendón del cuádriceps. Se decide reanclaje del mismo en el polo superior de la rótula, seguido de rehabilitación. Después del tratamiento quirúrgico realizado el paciente recupera el balance articular y muscular. La rotura del tendón del cuádriceps es excepcional en la edad pediátrica. La realización de una buena exploración, tanto clínica como radiológica es fundamental. El tratamiento viene determinado por el tipo de rotura y la clínica asociada. Hemos realizado una revisión bibliográfica de la literatura con el fin de dar a conocer este tipo de patología y su manejo.Rupture of the quadriceps tendon is a common pathology in adults, but exceptionally rare in children. The case reported is that of a 9-year old boy with a 2-month history of pain in the left knee without any clear history of trauma. Magnetic Resonance Imaging study was carried out, leading to the diagnosis of partial tear of the left quadricipital tendon. The tendon was re-anchored at the upper pole of the patella, followed by rehabilitation. The patient recovered joint and muscular balance after the surgery. Rupture of the quadriceps tendon is exceptionally rare at pediatric ages. A thorough examination, both clinical as well as radiological, is of fundamental importance. Treatment is determined by the kind of rupture and associated clinical symptoms. We have carried out a bibliographical review of the literature in order to offer a better understanding of this pathology and its treatment

Sarcoma fibroblástico mixoinflamatorio en el pie: presentación de un caso y revisión de la literatura

El Sarcoma Fibroblástico Mixoinflamatorio (SFMI) es un sarcoma de escasa frecuencia, que aparece habitualmente en adultos durante la cuarta y quinta década de la vida como una masa de partes blandas, subcutánea, indolora, de preferencia localizada en partes acras, aunque también puede presentarse en otras localizaciones. Se presenta el caso de una mujer de 35 años con una tumoración a nivel del primer espacio dorsal del pie derecho, indolora, de 4 meses de evolución sin antecedente traumático. Se realizó una exéresis quirúrgica de la lesión. El estudio de la anatomía patológica estableció el diagnóstico de Sarcoma Fibroblástico Mixoinflamatorio. Esta lesión es una tumoración rara, por lo que habitualmente su diagnóstico es a menudo tardío. Hemos realizado una revisión exhaustiva de la literatura con el fin de dar a conocer este tipo de tumoración y su manejo.Fibroblastic Mixoinflamatory Sarcoma is a malignant tumor of low frequency, developed in adults during the fourth and fifth decade of life as a soft tissue subcutaneous mass, usually painless, placed distally in the distal extremities. We report the case of a 35 years-old female with a painless tumour at the first dorsal space of the right foot, of 4 months evolution. She did not refer any trauma history. We removed the lump and sent the sample to pathology department, which established the diagnosis of Fibroblastic Mixoinflamatory Sarcoma. Fibroblastic Mixoinflamatory Sarcoma is a rare tumour, often misdiagnose. We carried out a thorough review of the literature to divulge this type of tumour and its management

Cannabidiol treatment might promote resilience to cocaine and methamphetamine use disorders: A review of possible mechanisms

Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors describe the scarce preclinical and human research about the actions of CBD on the effects of stimulant drugs, mainly cocaine and methamphetamine (METH). Additionally, the possible mechanisms underlying the therapeutic potential of CBD on stimulant use disorders are reviewed. CBD has reversed toxicity and seizures induced by cocaine, behavioural sensitization induced by amphetamines, motivation to self-administer cocaine and METH, context- and stress-induced reinstatement of cocaine and priming-induced reinstatement of METH seeking behaviours. CBD also potentiated the extinction of cocaine- and amphetamine-induced conditioned place preference (CPP), impaired the reconsolidation of cocaine CPP and prevented priming-induced reinstatement of METH CPP. Observational studies suggest that CBD may reduce problems related with crack-cocaine addiction, such as withdrawal symptoms, craving, impulsivity and paranoia (Fischer et al., 2015). The potential mechanisms involved in the protective effects of CBD on addiction to psychostimulant drugs include the prevention of drug-induced neuroadaptations (neurotransmitter and intracellular signalling pathways changes), the erasure of aberrant drug-memories, the reversion of cognitive deficits induced by psychostimulant drugs and the alleviation of mental disorders comorbid with psychostimulant abuse. Further, preclinical studies and future clinical trials are necessary to fully evaluate the potential of CBD as an intervention for cocaine and methamphetamine addictive disorders

Desarrollo de una ontología en el contexto de la web semántica a partir de un tesauro documental tradicional

A thesaurus is a documentary tool that is used to catalog and retrieve information in specialized environments. In the search for better alternatives in the representation of information resources, ontologies—in the context of the semantic web—are being seen as a new means of representing the knowledge that currently exists in thesauri, now that it has been demonstrated that ontologies make it possible to improve the precision and the reutilization of all kinds of knowledge. The objective of this work is to present an option for the migration of the traditional documentary thesaurus to ontology in the environment of the semantic web, with the objective of permitting its use in document retrieval

Appearance of pyrophyllite as replacements of spiriferids (Brachiopoda) Shells of the devonian in the Central-Iberian zone (Hesperic Massif, Spain).

[Abstract] Amacroscopic pyrophyllite bearing mineralization related to shells ofspiriferids has beeen found in the Herrera Formation (southern Central-Iberian Zone, Hesperic Massif, Spain). The observed mineral asociation is pyrophyllite + nacrite + quartz + calcite + anhydrite, and it is interpreted as resulting from the substitution ofinitial carbonatic shell by a Si, Al, S rich hydrothermal solutio

Intermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice

A novel approach to reduce the incidence of substance use disorders is to promote resilience to stress using environmental resources such as physical exercise. In the present study we test the hypothesis that Voluntary Wheel Running (VWR) during adolescence blocks the negative consequences of stress induced by intermittent repeated social defeat (IRSD). Four groups of adolescent male C57BL/6 mice were employed in the experiment; two groups were exposed to VWR (1 h, 3 days/week) from postnatal day (PND) 21 until the first social defeat (PND 47), while the remaining two groups did not have access to activity wheels (controls). On PND 47, 50, 53 and 56 mice, who had performed VWR, were exposed to an episode of social defeat by a resident aggressive mouse (VWR+IRSD group) or allowed to explore an empty cage (VWR+EXPL group). The same procedure was performed with control mice that had not undergone VWR (CONTROL+IRSD and CONTROL+EXPL groups). On PND 57, all the mice performed the Elevated Plus Maze (EPM), Hole-Board, Social Interaction, Tail Suspension and Splash tests. After an interval of 3 weeks, all mice underwent a conditioned place preference (CPP) procedure with 1 mg/kg of cocaine. Exposure to VWR prevented the negative consequences of social stress in the EPM, splash test and CPP, since the VWR+IRSD group did not display anxiety- or depression-like effects or the potentiation of cocaine reward observed in the Control+IRSD group. Our results support the idea that physical exercise promotes resilience to stress and represents an excellent target in drug abuse prevention. © 202

Brief maternal separation inoculates against the effects of social stress on depression-like behavior and cocaine reward in mice

Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm. According to the “inoculation of stress” hypothesis, a brief period of maternal separation (MS) can provide protection against the negative effects of IRSD. The aim of the present study was to assess whether exposure to a brief episode of MS prevents the subsequent short-term effects of IRSD on depression- and anxiety-like behaviors and to explore its long-term effects on cocaine CPP in mice. Four groups of male C57BL/6 mice were employed; two groups were separated from their mother 6 h on postnatal day (PND) 9], while the other two groups were not (controls). On PND 47, 50, 53 and 56, mice that had experienced MS were exposed to social defeat in the cage of an aggressive resident mouse (MS + IRSD group) or were allowed to explore an empty cage (MS + EXPL group). The same procedure was performed with control mice that had not experienced MS (CONTROL + IRSD and CONTROL + EXPL groups). On PND57-58, all the mice performed the elevated plus maze and the hole-board, social interaction and splash tests. Three weeks after the last episode of defeat, all the mice underwent the CPP procedure with cocaine (1 mg/kg). Irrespective of whether or not MS had taken place, a reduction in open arms measures, dips, and social interaction was observed in mice that experienced IRSD. A higher latency of grooming and acquisition of cocaine-induced CPP were observed only in mice exposed to IRSD alone (CONTROL + IRSD). These results suggest that exposure to a brief episode of stress early in life increases the subsequent resilience of animals to the effects of social stress on vulnerability to cocaine. Copyright © 2022 Calpe-López, Martínez-Caballero, García-Pardo and Aguilar

Isobaric molar heat capacities of the mixture (p-cymene + ethanol) at several temperatures and atmospheric pressure

Experimental isobaric molar heat capacities at atmospheric pressure have been determined every 10 K for the mixture p-cymene (1) + ethanol (2) in the temperature interval (298.6–328.4) K over the whole composition range with a Calvet type calorimeter. Densities, necessary for calculating heat capacities, have been also measured in the same conditions. Excess molar volumes have been calculated from densities. Excess molar heat capacities have been calculated from the molar heat capacities, their values being positive and increasing as the temperature rises. Excess properties are discussed in terms of intermolecular interactions. The solvation model COSMO-RS has been applied to predict the excess molar heat capacities. The model predicts fairly well the values of the excess heat capacities

Meropenem heteroresistance in clinical isolates of OXA-48–producing Klebsiella pneumoniae

OXA-48–producing Klebsiella pneumoniae isolates often show growth of colonies within inhibition zones in carbapenem diffusion assays. The nature of these colonies was investigated in a series of clinical isolates of OXA-48–producing K. pneumoniae obtained in the context of a hospital outbreak, and they were found to be persistent colonies that reproduced again the same phenotype when they were collected and tested in diffusion assays again. The frequency of mutations conferring resistance to meropenem (8 µg/mL) was determined for the same isolates. The average mutation frequency was 5.47·10-6 (range: 2.59·10-8–5.87·10-5), and the analysis of several resistant mutants showed that all of them had mutations in the ompK36 porin gene. Heteroresistance was investigated using population analysis profiling. The profiles were compatible with mutation frequency assays, and all the colonies analyzed were resistant mutants. In OXA-48–producing K. pneumoniae, the growth of persisters seems to be specific of diffusion assays

Enhanced dimerization of TiOCl under pressure: spin-Peierls - to - Peierls transition

We report high-pressure x-ray diffraction and magnetization measurements combined with ab-initio calculations to demonstrate that the high-pressure optical and transport transitions recently reported in TiOCl, correspond in fact to an enhanced Ti3+-Ti3+ dimerization existing already at room temperature. Our results confirm the formation of a metal-metal bond between Ti3+ ions along the b-axis of TiOCl, accompanied by a strong reduction of the electronic gap. The evolution of the dimerization with pressure suggests a crossover from the spin-Peierls to a conventional Peierls situation at high pressures.Comment: 9pages, 4 figure