Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"

Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad “Debates en torno a la NUEVa Agenda Urbana”, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB –Instituto de Investigación de Vivienda y Hábitat y MGyDH-Maestría en Gestión y Desarrollo Habitacional-1), hemos convidado un espacio que se concretó con potencia en un debate transdisciplinario. Convocó a intelectuales de prestigio internacional, investigadores, académicos y gestores estatales, y en una metodología de innovación articuló las voces académicas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes están trabajando en los desafíos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI

Understanding the adipose tissue acetylome in obesity and insulin resistance.

Obesity is a widely prevalent pathology with a high exponential growth worldwide. Altered lipid accumulation by adipose tissue is one of the main causes of obesity and exploring lipid homeostasis in this tissue may represent a source for the identification of possible therapeutic targets. The study of the proteome and the post-translational modifications of proteins, specifically acetylation due to its involvement in energy metabolism, may be of great interest to understand the molecular mechanisms involved in adipose tissue dysfunction in obesity. The objective of this study was to characterize the subcutaneous and omental adipose tissue acetylome in conditions of obesity and insulin resistance and to describe the importance of acetylation of key molecules in adipose tissue to use them as therapeutic targets. The results describe for the first time the acetylome of subcutaneous and omental adipose tissue under physiological and physiopathological conditions such as obesity and insulin resistance. New evidence showed different acetylation patterns between two main depots and highlight the molecular complexity of adipose tissue. Results showed changes in FABP4 acetylation in subcutaneous fat in relation to insulin resistance, thus unveiling a potential marker of depot-specific dysfunctional expansion in obesity-associated metabolic disease. Furthermore, it is shown that the acetylation of FABP4 affects its function, modulating the capacity of differentiation in adipocytes. In conclusion, this study demonstrates a profound, depot-specific alteration of adipose tissue acetylome, wherein the acetylation of FABP4 may play a key role in adipocyte differentiation and lipid accumulation

Cardiac Tamponade Associated with the Presentation of Anaplastic Large Cell Lymphoma in a 2-Year-Old Child

The anaplastic large cell lymphoma is a rare entity in pediatric patients. We present an unusual case of pericardial involvement, quite uncommon as extranodal presentation of this type of disorder, that provoked a life-risk situation requiring an urgent pericardiocentesis. To our knowledge, this is the first report on a child with pericardial involvement without an associated cardiac mass secondary to anaplastic large cell lymphoma in pediatric age. We report the case of a 21-month-old Caucasian male infant with cardiac tamponade associated with the presentation of anaplastic large cell lymphoma. Initially, the child presented with 24-day prolonged fever syndrome, cutaneous lesions associated with hepatomegaly, inguinal adenopathies, and pneumonia. After a 21-day asymptomatic period, polypnea and tachycardia were detected in a clinical check-up. Chest X-ray revealed a remarkable increase of the cardiothoracic index. The anaplastic large cell lymphoma has a high incidence of extranodal involvement but myocardial or pericardial involvements are rare. For this reason, we recommend a close monitoring of patients with a differential diagnosis of anaplastic large cell lymphoma

The caveolae-associated coiled-coil protein, NECC2, regulates insulin signalling in Adipocytes

Adipocyte dysfunction in obesity is commonly associated with impaired insulin sig-nalling in adipocytes and insulin resistance. Insulin signalling has been associatedwith caveolae, which are coated by large complexes of caveolin and cavin proteins,along with proteins with membrane‐binding and remodelling properties. Here, weanalysed the regulation and function of a component of caveolae involved in growthfactor signalling in neuroendocrine cells, neuroendocrine long coiled‐coil protein‐2(NECC2), in adipocytes. Studies in 3T3‐L1 cells showed that NECC2 expressionincreased during adipogenesis. Furthermore, NECC2 co‐immunoprecipitated withcaveolin‐1 (CAV1) and exhibited a distribution pattern similar to that of the compo-nents of adipocyte caveolae, CAV1, Cavin1, the insulin receptor and cortical actin.Interestingly, NECC2 overexpression enhanced insulin‐activated Akt phosphoryla-tion, whereas NECC2 downregulation impaired insulin‐induced phosphorylation ofAkt and ERK2. Finally, an up‐regulation ofNECC2in subcutaneous and omental adi-pose tissue was found in association with human obesity and insulin resistance. Thiseffect was also observed in 3T3‐L1 adipocytes exposed to hyperglycaemia/hyperin-sulinemia. Overall, the present study identifies NECC2 as a component of adipocytecaveolae that is regulated in response to obesity and associated metabolic complica-tions, and supports the contribution of this protein as a molecular scaffold modulat-ing insulin signal transduction at these membrane microdomains

The caveolae-associated coiled-coil protein, NECC2, regulates insulin signalling in Adipocytes

Adipocyte dysfunction in obesity is commonly associated with impaired insulin sig-nalling in adipocytes and insulin resistance. Insulin signalling has been associatedwith caveolae, which are coated by large complexes of caveolin and cavin proteins,along with proteins with membrane‐binding and remodelling properties. Here, weanalysed the regulation and function of a component of caveolae involved in growthfactor signalling in neuroendocrine cells, neuroendocrine long coiled‐coil protein‐2(NECC2), in adipocytes. Studies in 3T3‐L1 cells showed that NECC2 expressionincreased during adipogenesis. Furthermore, NECC2 co‐immunoprecipitated withcaveolin‐1 (CAV1) and exhibited a distribution pattern similar to that of the compo-nents of adipocyte caveolae, CAV1, Cavin1, the insulin receptor and cortical actin.Interestingly, NECC2 overexpression enhanced insulin‐activated Akt phosphoryla-tion, whereas NECC2 downregulation impaired insulin‐induced phosphorylation ofAkt and ERK2. Finally, an up‐regulation ofNECC2in subcutaneous and omental adi-pose tissue was found in association with human obesity and insulin resistance. Thiseffect was also observed in 3T3‐L1 adipocytes exposed to hyperglycaemia/hyperin-sulinemia. Overall, the present study identifies NECC2 as a component of adipocytecaveolae that is regulated in response to obesity and associated metabolic complica-tions, and supports the contribution of this protein as a molecular scaffold modulat-ing insulin signal transduction at these membrane microdomains

Anales de Edafología y Agrobiología Tomo 47 Número 9-10

l. Suelos. La evaporación y evapotranspiración en el campo de Cartagena y vega media del Segura. Primeros resultados. Por, M. I . Sánchez-Toribio, F. López-Bermudez, F. del Amor y A . Torrecillas.-- Estudio mediante un simulador de lluvia del comportamiento de suelos de Valencia (España) frente a los procesos de erosión por escorrentía y salpicadura. Por, P. Sanroque, J. L. Rubio y L. Izquierdo.-- Química Adsorción de clorprofan (CIPC) por suelos. Por, G. Dios Cancela, J. A . Guillén Alfaro y S. González García.-- Relations betweeri B (total available) and severa! constituents of cultivated soils. Por, A. Ruiz-Nieto, E. Barahona, S. Jaime y A. Aguilar.-- Aplicación de disolución no tamponadas para la extracción de aluminio "activo" ligado a la materia orgánica en suelos ácidos de Galicia. Por, M. Urrutia Mera, E. García-Rodeja Gayoso y F. Macías Vázquez.-- Caracterización química y mineralógica de las formas de hierro en suelos sobre sustrato calizo de Galicia (NW de España). Por, M. T. Barral Silva, M. T. Taboada Castro y F. Guitián Ojea.—Biología. Estructura y variabilidad de las nematocenosis en relación con diversos factores bióticos y abióticos del medio en una vaguada adehesada del Oeste español. Por, J. J. Ibáñez, A. Blanco, A. Bello y J. L. Revuelta.-- Génesis, Clasificación y Cartografía. Suelos de la Isla de Gomera (l. Canarias). III. Meseta central. Ecología, características morfológicas, físico-químicas, mineralógicas, micromorfológicas, clasificación e interpretación. Po r, A . Rodríguez Rodríguez, M. L. Tejedor Salguero y C. Jiménez Mendoza.-- Mosaicos heterocrónicos, heterogénicos y heterolíticos en el macizo de Ayllón (Sistema Central). Repercusiones sobre la tipología de los suelos. Por, J. J. Ibáñez, A. López Lafuente, A. García Alvarez y R. García Giménez.-- Fraccionamiento y distribución de óxidos de hierro en superficies de tipo Raña y altas terrazas al sur del macizo de Ayllón y Somosierra (Sistema Central). Por, R. Jiménez Ballesta, J. J. Ibáñez, F. Monturiol, L. Alcalá y M. L. Palomar.-- Fertilidad. Dinámica de la fracción ligera de la materia orgánica en relación a la producción de nitratos a campo. Por, P. Hashimoto, J. Sierra y L. Barberis.-- II. Biología Vegetal.-Nutrición.-- Absorción del nitrógeno contenido en el agua residual depurada y su influencia en el rendimiento. Por, V. Pérez García, D. González de Chavez Rojo y E. Iglesias Gimenez.-- La nutrición N -NH4 durante el estado vegetativo de Nicotiana Rústica L.: Su efecto sobre el crecimiento. Por, M. D. Saco y M. S. Martín.-- Influencia de nutrientes y polifenoles en la descomposición de la hojarasca de especies autóctonas e introducidas en el sureste español. Por, M. T. Domínguez de Juan, E. González Esparcia y F. Penalva Rodríguez.-- Fisiología Fitotoxicidad por zinc : efectos sobre el crecimiento y contencido de pigmentos fotosintéticos en Phaseolus vulgar1s L. a Jo largo del ciclo de desarrollo . Por, A. Ruano, J. Barceló y Ch. Poschenrieder.-- Efectos del pH ácido y del aluminio sobre Pueraria phaseoloides en simbiosis con Bradyrhizobium SP. Por, C. R. Morales, M. J. Delgado y E. J. BedmarPeer reviewe