PREGRIDBAL 1.0: towards a high-resolution rainfall atlas for the Balearic Islands (1950–2009)

This work presents a catalog of daily precipitation fields in the Balearic Islands created with data from AEMET (State Meteorological Agency) assistant observations, including records from 1912. The original digital daily data file has been interpolated onto a regular 100 m-resolution grid (namely PREGRIDBAL), defined with the aim of becoming a valid standard for future methodological improvements and catalog upgrades. Daily precipitation amounts on each grid point are calculated using an analysis method based on ordinary kriging, using the daily anomaly with respect to the annual mean for all available observations each day. Due to quality concerns, the time span for products derived from the catalog is limited to the 1950–2009 period, when the number of operating stations reached 200.The study has partially been funded by the “Conselleria d’Educació, Cultura i Universitats del Govern de les Illes Balears” and FEDER fund (project 7/2011 competitive research groups) and Ministry of Science and Innovation (projects CGL2011-24458 and CGL2014-52199-R)

Acute upper airway obstruction due to retropharyngeal hematoma in a dog with Anaplasma species: a case study

Antecedentes: El hematoma retro-faríngeo es una rara afección que es difícil de diagnosticar y puede progresar rápidamente a la obstrucción de las vías respiratorias. Los autores reportan el primer caso conocido de la obstrucción aguda de la vía aérea superior resultante de hematoma retro-faríngeo en un perro. Causas documentadas en medicina humana han incluido coagulopatía, trauma, infección, adenoma paratiroideo ruptura, y la ingestión de cuerpo extraño. Síntomas vagos en los seres humanos como dolor de garganta, disfonía, disnea, disfagia y la hinchazón del cuello puede preceder a la obstrucción de las vías aéreas letales. Presentación de casos: Los autores presentan el caso de una paciente hembra Spaniel de agua, de 18 meses de edad, con trombocitopenia que desarrolló un gran hematoma retro-faríngeo y síntomas de compromiso de la vía aérea. El perro requiere intubación traqueal, seguida por la traque-ostomía quirúrgica. Radiografía cervical lateral y la resonancia magnética del cuello fue compatible con un hematoma retro-faríngeo comprometer la vía respiratoria. El hematoma retro-faríngeo fue gestionado de forma conservadora. Conclusión: El hematoma retrofaríngeo debe ser considerada en pacientes con dificultad respiratoria brusca. La resonancia magnética permite el diagnóstico específico de una rara afección que de otro modo es difícil de diagnosticar.Background: Retropharyngeal hematoma is a rare condition that is difficult to diagnose and may progress rapidly to airway obstruction. The authors report the first known case of acute upper airway obstruction resulting from retropharyngeal hematoma in a dog. Documented causes in human medicine have included coagulopathic states, trauma, infection, parathyroid adenoma rupture, and foreign body ingestion. Vague symptoms in humans such as sore throat, shortness of breath, dysphonia, dysphagia, and neck swelling may precede lethal airway obstruction. Case presentation: The authors report a case of an 18-month-old, intact female water spaniel with thrombocytopenia that developed a massive retropharyngeal hematoma and symptoms of airway compromise. The dog required tracheal intubation followed by surgical tracheostomy. Lateral cervical radiography and magnetic resonance imaging of the neck was consistent with a retropharyngeal hematoma compromising the airway. The retropharyngeal hematoma was managed conservatively. Conclusion: Retropharyngeal hematoma should be considered in patients presenting with abrupt respiratory distress.Magnetic resonance imaging allowed specific diagnosis of a rare condition that is otherwise difficult to diagnose

Otter-Knowledge: benchmarks of multimodal knowledge graph representation learning from different sources for drug discovery

Recent research in representation learning utilizes large databases of proteins or molecules to acquire knowledge of drug and protein structures through unsupervised learning techniques. These pre-trained representations have proven to significantly enhance the accuracy of subsequent tasks, such as predicting the affinity between drugs and target proteins. In this study, we demonstrate that by incorporating knowledge graphs from diverse sources and modalities into the sequences or SMILES representation, we can further enrich the representation and achieve state-of-the-art results on established benchmark datasets. We provide preprocessed and integrated data obtained from 7 public sources, which encompass over 30M triples. Additionally, we make available the pre-trained models based on this data, along with the reported outcomes of their performance on three widely-used benchmark datasets for drug-target binding affinity prediction found in the Therapeutic Data Commons (TDC) benchmarks. Additionally, we make the source code for training models on benchmark datasets publicly available. Our objective in releasing these pre-trained models, accompanied by clean data for model pretraining and benchmark results, is to encourage research in knowledge-enhanced representation learning

Gamificación en Anestesiología Clínica Veterinaria: Ampliación

Desarrollo de un juego de mesa que permitan el aprendizaje de conceptos teóricos relacionados con la anestesia en un entorno de gamificación

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

PREGRIDBAL 1.0: towards a high-resolution rainfall atlas for the Balearic Islands (1950-2009)

This work presents a catalog of daily precipitation fields in the Balearic Islands created with data from AEMET (State Meteorological Agency) assistant observations, including records from 1912. The original digital daily data file has been interpolated onto a regular 100 m-resolution grid (namely PREGRIDBAL), defined with the aim of becoming a valid standard for future methodological improvements and catalog upgrades. Daily precipitation amounts on each grid point are calculated using an analysis method based on ordinary kriging, using the daily anomaly with respect to the annual mean for all available observations each day. Due to quality concerns, the time span for products derived from the catalog is limited to the 1950-2009 period, when the number of operating stations reached 200. Therefore, from the time series of daily maps, monthly-, annual-, quinquennial-, and decadal-accumulations are produced. Similarly, the catalog allowed for quantification of climate trends in rainfall amounts in the Balearic Islands, with the significant advantage of minimizing the biases originated from heterogeneities in the spatial distribution of stations across the archipelago. Results show a general decrease in precipitation during the 1950-2009 period. From 1950 to 1979, the average annual precipitation across the islands was 624.3 mm, while from 1980 to 2009 it diminished to 555.36 mm. Changes in precipitation patterns, which vary among the different areas, are also detected. The most significant reductions are found in the northern half of the archipelago and especially in Mallorca, where the Tramuntana mountain range stands out. All seasonal trends show a decrease, with values ranging between 1 and 3 mm decade−1, with the exception of autumn, which reaches a positive trend up to 7 mm decade−1. October shows the most dramatic decrease (−10. 34 mm decade−1) and, conversely, September and November show an increase in precipitation (3.28 and 1.82 mm decade−1, respectively) with a statistical significance above 85 % across almost the entire archipelago, and even exceeding 95 % in Eivissa and Formentera

'The Good, the Bad and the Double-Sword' Effects of Microplastics and Their Organic Additives in Marine Bacteria

[eng] Little is known about the direct effects of microplastics (MPs) and their organic additives on marine bacteria, considering their role in the nutrient cycles, e.g., N-cycles through the N2-fixation, or in the microbial food web. To fill this gap of knowledge, we exposed marine bacteria, specifically diazotrophs, to pure MPs which differ in physical properties (e.g., density, hydrophobicity and/or size), namely, polyethylene, polypropylene, polyvinyl chloride and polystyrene, and to their most abundant associated organic additives (e.g., fluoranthene, 1,2,5,6,9,10-hexabromocyclododecane and dioctyl-phthalate). Growth, protein overproduction, direct physical interactions between MPs and bacteria, phosphorus acquisition mechanisms and/or N2-fixation rates were evaluated. Cyanobacteria were positively affected by environmental and high concentrations of MPs, as opposed to heterotrophic strains, that were only positively affected with high concentrations of ~120 µm-size MPs (detecting the overproduction of proteins related to plastic degradation and C-transport), and negatively affected by 1 µm-size PS beads. Generally, the organic additives had a deleterious effect in both autotrophic and heterotrophic bacteria and the magnitude of the effect is suggested to be dependent on bacterial size. Our results show species-specific responses of the autotrophic and heterotrophic bacteria tested and the responses (beneficial: the 'good', deleterious: the 'bad' and/or both: the 'double-sword') were dependent on the type and concentration of MPs and additives. This suggests the need to determine the threshold levels of MPs and additives concentrations starting from which significant effects can be observed for key microbial populations in marine systems, and these data are necessary for effective environmental quality control management

Espacios y destinos turísticos en tiempos de globalización y crisis

2 volúmenesXII Coloquio de Geografía del Turismo, Ocio y Recreación de la Asociación de Geógrafos Españoles. Colmenarejo (Madrid), del 17 al 19 de junio de 2010.Este libro ha sido editado con la colaboración económica del Ministerio de Ciencia e Innovación (ref. CS02010-10416-E)