Philips' Geographical Pictures

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Isa A. Roberts Drapery, Grocery, boots and shoes store with bullock team and wagon

Mrs Isa A Roberts was born Isabella Alice Kirwan, Windsor NSW in 1846. She married Mark Roberts in Queensland 16 Aug 1870. Isa Roberts died 1925 and was buried at St George General Cemetery. Mark Roberts was born in Sydney around 1848 and died 24 May 1880 at St George, Queensland. Isa A Roberts was known as a dressmaker in St George and later took over the shop known as Defiance Stores. She left the store in 1918 and it was taken over by Thomas Austin. Earliest reference for the store is in 1909 but that is the same year that the Belonne Beacon began so the store could have been around for longer

Queen Victoria's Royal visit to Dublin, Ireland, 4th April - 26th April, 1900

Peacock Hotel on right , College Green, Trinity College Dublin, God Bless our Queen banner in background , National Assurance Company building. Statue of William of Orange (William III) on College Green, erected in 1701. It was badly damaged in an explosion in 1928, and removed in 1929

ESP administration and ESP teacher training

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/88132/1/swales-esp_administration.pd

Gender and Medieval archaeology: storming the castle

Despite feminist critiques over three decades, Archaeological scholarship remains predominantly focused on exploring patriarchal narratives and is thereby complicit in reinforcing structural inequalities. Questions must be asked of how the construction of archaeological knowledge affects representation and impacts on our ‘archaeologies’. This paper explores the relative absence of gendered approaches within Archaeology through the lens of Later Medieval Archaeology in particular, and with a micro-focus on Castle-studies in Britain and Ireland. Is there a reason for the silence in relation to gender in the archaeology of the later middle ages

Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity

Objectives. B cells drive the production of autoreactive antibodysecreting cells, ASCs, in autoimmune diseases such as Systemic Lupus Erythematosus, SLE, and Sjogren, s syndrome, causing long-, term organ damage. Current treatments for antibody-mediated autoimmune diseases target B cells or broadly suppress the immune system. However, pre-existing long-lived ASCs are often refractory to treatment, leaving a reservoir of autoreactive cells that continue to produce antibodies. Therefore, the development of novel treatment methods targeting ASCs is vital to improve patient outcomes. Our objective was to test whether targeting the epigenetic regulator BMI-, could deplete ASCs in autoimmune conditions in vivo and in vitro. Methods. Use of a BMI-, inhibitor in both mouse and human autoimmune settings was investigated. Lyn, mice, a model of SLE, were treated with the BMI-, small molecule inhibitor PTC-, before assessment of ASCs, serum antibody and immune complexes. To examine human ASC survival, a novel human fibroblast-based assay was established, and the impact of PTC-, on ASCs derived from Sjogren, s syndrome, patients was evaluated. Results. BMI-, inhibition significantly decreased splenic and bone marrow ASCs in Lyn, mice. The decline in ASCs was linked to aberrant cell cycle gene expression and led to a significant decrease in serum IgG, immune complexes and anti-DNA IgG. PTC-, was also efficacious in reducing ex vivo plasma cell survival from both Sjogren, s syndrome, patients and age-matched healthy donors. Conclusion. These data provide evidence that inhibiting BMI-, can deplete ASC in a variety of contexts and thus BMI-, is a viable therapeutic target for antibody-mediated autoimmune diseases.Jack Polmear, Lauren Hailes, Moshe Olshansky, Maureen Rischmueller, Elan L'Estrange-Stranieri, Anne L Fletcher, Margaret L Hibbs, Vanessa L Bryant, Kim L Good-Jacobso