2,408 research outputs found
Reading In English By Children In Korea: Frequency, Effectiveness, And Barriers
A study of the English non-textbook reading of fourth graders in Korea revealed that about 80% had done at least some reading, confirming that there is enthusiasm for English reading. About half, however, had read only five books or fewer. Non-readers said that the reason they did not read in English was the difficulty of English texts. Those who read more did better on a test of English spelling and vocabulary
Improving STING Agonist Delivery for Cancer Immunotherapy Using Biodegradable Mesoporous Silica Nanoparticles
Stimulator of interferon genes (STING) activation by intratumoral STING agonist treatment has been recently shown to eradicate tumors in preclinical models of cancer immunotherapy, generating intense research interest and leading to multiple clinical trials. However, there are many challenges associated with STING agonistābased cancer immunotherapy, including low cellular uptake of STING agonists. Here, biodegradable mesoporous silica nanoparticles (bMSN) with an average size of 80Ā nm are developed for efficient cellular delivery of STING agonists. STING agonists delivered via bMSN potently activate innate and adaptive immune cells, leading to strong antitumor efficacy and prolonged animal survival in murine models of melanoma. Delivery of immunotherapeutic agents via biodegradable bMSN is a promising approach for improving cancer immunotherapy.Biodegradable mesoporous silica nanoparticles enhance cellular delivery of stimulator of interferon genes (STING) agonists and achieve greater antitumor therapeutic efficacy than free STING agonists in murine models of melanoma. Biodegradable mesoporous silica nanoparticles are a promising platform for cancer immunotherapy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/163388/3/adtp202000130_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163388/2/adtp202000130.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/163388/1/adtp202000130-sup-0001-SuppMat.pd
J/psi hadron interaction in vacuum and in QGP
Motivated by the recent lattice data that will survive up to
1.6, we calculate the thermal width of at finite temperature in
perturbative QCD. The inputs of the calculation are the parton quarkonium
dissociation cross sections at the NLO in QCD, which were previously obtained
by Song and Lee, and a gaussian charmonium wave function, whose size were
fitted to an estimate by Wong by solving the schrodinger equation for
charmonium in a potential extracted from the lattice at finite temperature. We
find that the total thermal width above 1.4 becomes larger than 100 to 200
MeV, depending on the effective thermal masses of the quark and gluon, which we
take it to vary from 600 to 400 MeV.Comment: 4 pages, Talk at Quark Matter 200
Experimental observation of hidden Berry curvature in inversion-symmetric bulk 2H-WSe2
We investigate the hidden Berry curvature in bulk 2H-WSe2 by utilizing the
surface sensitivity of angle resolved photoemission (ARPES). The symmetry in
the electronic structure of transition metal dichalcogenides is used to
uniquely determine the local orbital angular momentum (OAM) contribution to the
circular dichroism (CD) in ARPES. The extracted CD signals for the K and K'
valleys are almost identical but their signs, which should be determined by the
valley index, are opposite. In addition, the sign is found to be the same for
the two spin-split bands, indicating that it is independent of spin state.
These observed CD behaviors are what are expected from Berry curvature of a
monolayer of WSe2. In order to see if CD-ARPES is indeed representative of
hidden Berry curvature within a layer, we use tight binding analysis as well as
density functional calculation to calculate the Berry curvature and local OAM
of a monolayer WSe2. We find that measured CD-ARPES is approximately
proportional to the calculated Berry curvature as well as local OAM, further
supporting our interpretation.Comment: 6 pages, 3 figure
ArabidopsisĀ ABCG14 is essential for the root-to-shoot translocation of cytokinin.
Cytokinins are phytohormones that induce cytokinesis and are essential for diverse developmental and physiological processes in plants. Cytokinins of the trans-zeatin type are mainly synthesized in root vasculature and transported to the shoot, where they regulate shoot growth. However, the mechanism of long-distance transport of cytokinin was hitherto unknown. Here, we report that the Arabidopsis ATP-binding cassette (ABC) transporter subfamily G14 (AtABCG14) is mainly expressed in roots and plays a major role in delivering cytokinins to the shoot. Loss of AtABCG14 expression resulted in severe shoot growth retardation, which was rescued by exogenous trans-zeatin application. Cytokinin content was decreased in the shoots of atabcg14 plants and increased in the roots, with consistent changes in the expression of cytokinin-responsive genes. Grafting of atabcg14 scions onto wild-type rootstocks restored shoot growth, whereas wild-type scions grafted onto atabcg14 rootstocks exhibited shoot growth retardation similar to that of atabcg14. Cytokinin concentrations in the xylem are reduced by similar to 90% in the atabcg14 mutant. These results indicate that AtABCG14 is crucial for the translocation of cytokinin to the shoot. Our results provide molecular evidence for the long-distance transport of cytokinin and show that this transport is necessary for normal shoot development.open118380Ysciescopu
Deformable Graph Transformer
Transformer-based models have recently shown success in representation
learning on graph-structured data beyond natural language processing and
computer vision. However, the success is limited to small-scale graphs due to
the drawbacks of full dot-product attention on graphs such as the quadratic
complexity with respect to the number of nodes and message aggregation from
enormous irrelevant nodes. To address these issues, we propose Deformable Graph
Transformer (DGT) that performs sparse attention via dynamically sampled
relevant nodes for efficiently handling large-scale graphs with a linear
complexity in the number of nodes. Specifically, our framework first constructs
multiple node sequences with various criteria to consider both structural and
semantic proximity. Then, combining with our learnable Katz Positional
Encodings, the sparse attention is applied to the node sequences for learning
node representations with a significantly reduced computational cost. Extensive
experiments demonstrate that our DGT achieves state-of-the-art performance on 7
graph benchmark datasets with 2.5 - 449 times less computational cost compared
to transformer-based graph models with full attention.Comment: 16 pages, 3 figure
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Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration.
The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans mechanosensory neuron axotomy model. We identify an unexpected role of the nicotinamide adenine dinucleotide (NAD+) synthesizing enzyme, NMAT-2/NMNAT, in axon regeneration. NMAT-2 inhibits axon regrowth via cell-autonomous and non-autonomous mechanisms. NMAT-2 enzymatic activity is required to repress regrowth. Further, we find differential requirements for proteins in membrane contact site, components and regulators of the extracellular matrix, membrane trafficking, microtubule and actin cytoskeleton, the conserved Kelch-domain protein IVNS-1, and the orphan transporter MFSD-6 in axon regrowth. Identification of these new pathways expands our understanding of the molecular basis of axonal injury response and regeneration
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