Measuring the maturity of open access: a preliminary study

Open access is an important part of scholarly communication, and it has been a global phenomenon. The growth of open access brings several signif-icant benefits to the general public as well as researchers, ultimately leads to the advancement of science. For the continuous growth and development of open access, it is necessary to measure the degree of maturity of open ac-cess. However, there is not much discussion about the assessment frame-work for open access. This study aims to propose an assessment framework of open access maturity. For the purpose of this study, we conducted an analysis with a total of 24 literatures relevant to the digital maturity, the ma-turity of open data/open science, and major open access initiatives. For digi-tal maturity, 18 articles were analyzed: 10 articles for generic purpose model, and 8 articles for industry-specific model. In addition, three articles on the maturity of open data/open science were analyzed and three major open ac-cess initiatives. In preliminary analysis results, three dimensions with 13 be-longing items were proposed for measuring the maturity of open access. Three dimensions are OA Policy, OA capability, and Openness quality. For OA policy, there are three items such as OA policy document, OA govern-ance, and OA strategy. For OA Capability, finance for OA, people for OA, culture for OA, and collaboration for OA are proposed. For Openness Quali-ty dimension, six items are suggested: submission and review, author rights, user rights, findability, accessibility, and monitoring

Medical and health sciences academics’ behaviours and attitudes towards open access publishing in scholarly journals: a perspective from South Korea

This article seeks to extend the knowledge of the behaviour and attitudes towards open access publishing through a survey that focusses on the attitudes and behaviours of academic researchers in Korea working in medicine and healthcare. Issues covered include: use of and intentions regarding OAP, and perceptions regarding advantages and disadvantages of OAP, journal article publication services, peer review, and re-use. A significant proportion of the articles (mean 58%) published by this group are published gold open access, consistent with the push in Korea towards international impact for their research. Researchers were more positive about the benefits of OAP than they were negative about its disadvantages. Analysis of responses on the basis of gender, and experience in publishing, showed some significant differences in attitudes to some statements

Prevalence and detection of low-allele-fraction variants in clinical cancer samples

Accurate detection of genomic alterations using high-throughput sequencing is an essential component of precision cancer medicine. We characterize the variant allele fractions (VAFs) of somatic single nucleotide variants and indels across 5095 clinical samples profiled using a custom panel, CancerSCAN. Our results demonstrate that a significant fraction of clinically actionable variants have low VAFs, often due to low tumor purity and treatment-induced mutations. The percentages of mutations under 5% VAF across hotspots in EGFR, KRAS, PIK3CA, and BRAF are 16%, 11%, 12%, and 10%, respectively, with 24% for EGFR T790M and 17% for PIK3CA E545. For clinical relevance, we describe two patients for whom targeted therapy achieved remission despite low VAF mutations. We also characterize the read depths necessary to achieve sensitivity and specificity comparable to current laboratory assays. These results show that capturing low VAF mutations at hotspots by sufficient sequencing coverage and carefully tuned algorithms is imperative for a clinical assay

The Role of Red Meat and Flavonoid Consumption on Cancer Prevention: The Korean Cancer Screening Examination Cohort

Markedly increased red meat consumption is a cancer risk factor, while dietary flavonoids may help prevent the disease. The purpose of this study was to investigate the associations of red meat and flavonoid consumption with cancer risk, based on data from 8024 subjects, drawn from the 2004–2008 Cancer Screening Examination Cohort of the Korean National Cancer Center. Hazard ratios (HRs) were obtained by using a Cox proportional hazard model. During the mean follow-up period of 10.1 years, 443 cases were newly diagnosed with cancer. After adjusting for age, there was a significant correlation between cancer risk and the daily intake of ≥43 g of red meat per day (HR 1.31; 95% CI 1.01, 1.71; p = 0.045), and total flavonoid intake tended to decrease cancer risk (HR 0.70; 95% CI 0.49, 0.99; highest vs. lowest quartile; p-trend = 0.073) in men. Following multivariable adjustment, there were no statistically significant associations between flavonoid intake and overall cancer risk in individuals with high levels of red meat intake. Men with low daily red meat intake exhibited an inverse association between flavonoid consumption and cancer incidence (HR 0.41; 95% CI 0.21, 0.80; highest vs. lowest; p-trend = 0.017). Additional research is necessary to clarify the effects of flavonoid consumption on specific cancer incidence, relative to daily red meat intake

Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres

Resident cancer cells with stem cell-like features induce drug tolerance, facilitating survival of glioblastoma (GBM). We previously showed that strategies targeting tumor bioenergetics present a novel emerging avenue for treatment of GBM. The objective of this study was to enhance the therapeutic effects of dual inhibition of tumor bioenergetics by combination of gossypol, an aldehyde dehydrogenase inhibitor, and phenformin, a biguanide compound that depletes oxidative phosphorylation, with the chemotherapeutic drug, temozolomide (TMZ), to block proliferation, stemness, and invasiveness of GBM tumorspheres (TSs). Combination therapy with gossypol, phenformin, and TMZ induced a significant reduction in ATP levels, cell viability, stemness, and invasiveness compared to TMZ monotherapy and dual therapy with gossypol and phenformin. Analysis of differentially expressed genes revealed up-regulation of genes involved in programmed cell death, autophagy, and protein metabolism and down-regulation of those associated with cell metabolism, cycle, and adhesion. Combination of TMZ with dual inhibitors of tumor bioenergetics may, therefore, present an effective strategy against GBM by enhancing therapeutic effects through multiple mechanisms of action

Erratum: The Role of Red Meat and Flavonoid Consumption on Cancer Prevention: The Korean Cancer Screening Examination Cohort; Nutrients 2017, 9, 938

The authors have requested the following corrections to their paper [...