1,173 research outputs found
Development of a high-performance transtibial cycling-specific prosthesis for the London 2012 Paralympic Games
Background and Aim
It has been reported that cycling-specific research relating to participants with an amputation is extremely limited in both volume and frequency. However, practitioners might participate in the development of cycling-specific prosthetic limbs. This technical note presents the development of a successful design of a prosthetic limb developed specifically for competitive cycling.
Technique
This project resulted in a hollow composite construction which was low in weight and shaped to reduce a rider’s aerodynamic drag.
Discussion
The new prosthesis reduces the overall mass of more traditional designs by a significant amount yet provides a more aerodynamic shape over traditional approaches. These decisions have yielded a measurable increase in cycling performance. Whilst further refinement is needed to reduce the aerodynamic drag as much as possible, this project highlights the benefits that can exist by optimising the design of sports-specific prosthetic limbs
A flight and analytical study of methods for reducing automatic-interceptor tracking errors caused by target maneuvers
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Aerial Damage Survey of the 2013 El Reno Tornado Combined with Mobile Radar Data
A detailed damage survey of the El Reno, Oklahoma, tornado of 31 May 2013 combined with rapid-scanning data recorded from two mobile radars is presented. One of the radars was equipped with polarimetric capability. The relationship between several suction vortices visually identified in pictures with the high-resolution Doppler velocity data and swath marks in fields is discussed. The suction vortices were associated with small shear features in Doppler velocity and a partial ringlike feature of high spectral width. For the first time, a suction vortex that created a swath mark in a field was visually identified in photographs and high-definition video while the rotational couplet was tracked by radar. A dual-Doppler wind synthesis of the tornadic circulation at low levels near the location of several storm chaser fatalities resolved ground-relative wind speeds in excess of 90 m s−1, greater than the minimum speed for EF5 damage. The vertical vorticity analysis revealed a rapid transition from a single tornadic vortex centered on the weak-echo hole (WEH) to suction vortices surrounding the WEH and collocated with the ring of enhanced radar reflectivities. Several bands/zones of enhanced convergence were resolved in the wind syntheses. One of the bands was associated with an internal or secondary rear-flank gust front. An inner band of convergence appeared to be a result of the positive bias in tornado-relative radial velocity owing to centrifuging of large lofted debris swirling within the tornado. An outer band of convergence formed at the northern edge of a region of strong inflow that was lofting small debris and dust into the storm
From single cells to tissues: interactions between the matrix and human breast cells in real time.
International audienceMammary gland morphogenesis involves ductal elongation, branching, and budding. All of these processes are mediated by stroma--epithelium interactions. Biomechanical factors, such as matrix stiffness, have been established as important factors in these interactions. For example, epithelial cells fail to form normal acinar structures in vitro in 3D gels that exceed the stiffness of a normal mammary gland. Additionally, heterogeneity in the spatial distribution of acini and ducts within individual collagen gels suggests that local organization of the matrix may guide morphogenesis. Here, we quantified the effects of both bulk material stiffness and local collagen fiber arrangement on epithelial morphogenesis. The formation of ducts and acini from single cells and the reorganization of the collagen fiber network were quantified using time-lapse confocal microscopy. MCF10A cells organized the surrounding collagen fibers during the first twelve hours after seeding. Collagen fiber density and alignment relative to the epithelial surface significantly increased within the first twelve hours and were a major influence in the shaping of the mammary epithelium. The addition of Matrigel to the collagen fiber network impaired cell-mediated reorganization of the matrix and increased the probability of spheroidal acini rather than branching ducts. The mechanical anisotropy created by regions of highly aligned collagen fibers facilitated elongation and branching, which was significantly correlated with fiber organization. In contrast, changes in bulk stiffness were not a strong predictor of this epithelial morphology. Localized regions of collagen fiber alignment are required for ductal elongation and branching suggesting the importance of local mechanical anisotropy in mammary epithelial morphogenesis. Similar principles may govern the morphology of branching and budding in other tissues and organs
Galactic Globular and Open Clusters in the Sloan Digital Sky Survey. I. Crowded Field Photometry and Cluster Fiducial Sequences in ugriz
We present photometry for globular and open cluster stars observed with the
Sloan Digital Sky Survey (SDSS). In order to exploit over 100 million stellar
objects with r < 22.5 mag observed by SDSS, we need to understand the
characteristics of stars in the SDSS ugriz filters. While star clusters provide
important calibration samples for stellar colors, the regions close to globular
clusters, where the fraction of field stars is smallest, are too crowded for
the standard SDSS photometric pipeline to process. To complement the SDSS
imaging survey, we reduce the SDSS imaging data for crowded cluster fields
using the DAOPHOT/ALLFRAME suite of programs and present photometry for 17
globular clusters and 3 open clusters in a SDSS value-added catalog. Our
photometry and cluster fiducial sequences are on the native SDSS 2.5-meter
ugriz photometric system, and the fiducial sequences can be directly applied to
the SDSS photometry without relying upon any transformations. Model photometry
for red giant branch and main-sequence stars obtained by Girardi et al. cannot
be matched simultaneously to fiducial sequences; their colors differ by
~0.02-0.05 mag. Good agreement (< ~0.02 mag in colors) is found with Clem et
al. empirical fiducial sequences in u'g'r'i'z' when using the transformation
equations in Tucker et al.Comment: 30 pages, 25 figures. Accepted for publication in ApJS. Version with
high resolution figures available at
http://www.astronomy.ohio-state.edu/~deokkeun/AnJohnson.pd
Are Ethnic and Gender Specific Equations Needed to Derive Fat Free Mass from Bioelectrical Impedance in Children of South Asian, Black African-Caribbean and White European Origin? Results of the Assessment of Body Composition in Children Study
Background
Bioelectrical impedance analysis (BIA) is a potentially valuable method for assessing lean mass and body fat levels in children from different ethnic groups. We examined the need for ethnic- and gender-specific equations for estimating fat free mass (FFM) from BIA in children from different ethnic groups and examined their effects on the assessment of ethnic differences in body fat.
Methods
Cross-sectional study of children aged 8–10 years in London Primary schools including 325 South Asians, 250 black African-Caribbeans and 289 white Europeans with measurements of height, weight and arm-leg impedance (Z; Bodystat 1500). Total body water was estimated from deuterium dilution and converted to FFM. Multilevel models were used to derive three types of equation {A: FFM = linear combination(height+weight+Z); B: FFM = linear combination(height2/Z); C: FFM = linear combination(height2/Z+weight)}.
Results
Ethnicity and gender were important predictors of FFM and improved model fit in all equations. The models of best fit were ethnicity and gender specific versions of equation A, followed by equation C; these provided accurate assessments of ethnic differences in FFM and FM. In contrast, the use of generic equations led to underestimation of both the negative South Asian-white European FFM difference and the positive black African-Caribbean-white European FFM difference (by 0.53 kg and by 0.73 kg respectively for equation A). The use of generic equations underestimated the positive South Asian-white European difference in fat mass (FM) and overestimated the positive black African-Caribbean-white European difference in FM (by 4.7% and 10.1% respectively for equation A). Consistent results were observed when the equations were applied to a large external data set.
Conclusions
Ethnic- and gender-specific equations for predicting FFM from BIA provide better estimates of ethnic differences in FFM and FM in children, while generic equations can misrepresent these ethnic differences
Bronchial artery revascularization in lung transplantation: a systematic review and meta-analysis.
Background: Bronchial artery revascularization (BAR) during lung transplantation has been hypothesized to improve early tracheal healing and delay the onset of bronchiolitis obliterans syndrome (BOS). We aimed to assess the outcomes of BAR after lung transplantation.
Methods: Electronic search in Ovid Medline, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Scopus, and Cochrane Controlled Trials Register (CCTR) databases was performed to identify all relevant studies published about lung transplantation with BAR. Studies discussing lung transplantation utilizing BAR were included while those without outcome data such as BOS and survival were excluded. Cohort-level data were extracted and pooled for analysis. A binary outcome meta-analysis of proportions with logit transformation was conducted. Newcastle-Ottawa scale was used for risk of bias assessment.
Results: Seven studies were selected for the analysis comprising 143 patients. Mean patient age was 47 (95% CI: 40-55) years. Sixty-one percent (48-72%) were male. Seventy-three percent (65-79%) of patients underwent double lung transplant while 27% (21-25%) underwent single lung transplant. In patients with postoperative angiography, successful BAR was demonstrated in 93% (82-97%) of all assessed conduits. The 30-day/in-hospital mortality was 6% (3-11%). Seventy-nine percent (63-89%) of patients were free from rejection at three months. Eighty-three percent (29-98%) of patients were free from signs of airway ischemia at three and six months. Pooled survival at one year and five years was 87% (78-92%) and 71% (46-87%), respectively, with a mean follow-up time of 21 (3-38) months. Pooled freedom from bronchiolitis obliterans was 86% (77-91%) at two years.
Conclusions: While this systematic review and meta-analysis is limited by the available surgeons, institutions, and papers discussing a highly specialized technique, it does show that BAR is a viable technique to minimize BOS and early anastomotic intervention following lung transplantation
The Multi-Object, Fiber-Fed Spectrographs for SDSS and the Baryon Oscillation Spectroscopic Survey
We present the design and performance of the multi-object fiber spectrographs
for the Sloan Digital Sky Survey (SDSS) and their upgrade for the Baryon
Oscillation Spectroscopic Survey (BOSS). Originally commissioned in Fall 1999
on the 2.5-m aperture Sloan Telescope at Apache Point Observatory, the
spectrographs produced more than 1.5 million spectra for the SDSS and SDSS-II
surveys, enabling a wide variety of Galactic and extra-galactic science
including the first observation of baryon acoustic oscillations in 2005. The
spectrographs were upgraded in 2009 and are currently in use for BOSS, the
flagship survey of the third-generation SDSS-III project. BOSS will measure
redshifts of 1.35 million massive galaxies to redshift 0.7 and Lyman-alpha
absorption of 160,000 high redshift quasars over 10,000 square degrees of sky,
making percent level measurements of the absolute cosmic distance scale of the
Universe and placing tight constraints on the equation of state of dark energy.
The twin multi-object fiber spectrographs utilize a simple optical layout
with reflective collimators, gratings, all-refractive cameras, and
state-of-the-art CCD detectors to produce hundreds of spectra simultaneously in
two channels over a bandpass covering the near ultraviolet to the near
infrared, with a resolving power R = \lambda/FWHM ~ 2000. Building on proven
heritage, the spectrographs were upgraded for BOSS with volume-phase
holographic gratings and modern CCD detectors, improving the peak throughput by
nearly a factor of two, extending the bandpass to cover 360 < \lambda < 1000
nm, and increasing the number of fibers from 640 to 1000 per exposure. In this
paper we describe the original SDSS spectrograph design and the upgrades
implemented for BOSS, and document the predicted and measured performances.Comment: 43 pages, 42 figures, revised according to referee report and
accepted by AJ. Provides background for the instrument responsible for SDSS
and BOSS spectra. 4th in a series of survey technical papers released in
Summer 2012, including arXiv:1207.7137 (DR9), arXiv:1207.7326 (Spectral
Classification), and arXiv:1208.0022 (BOSS Overview
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