Assessing social resilience to disasters at the neighbourhood level : co-producing a resilience assessment framework : a thesis presented in fulfilment of the requirements for the degree of Doctor of Philosophy in Psychology (Emergency Management) at Massey University, Wellington, New Zealand

All reprinted and copyrighted Figures have been removed, but they may be accessed via their source identified in the caption.Disasters of the past decade have drawn considerable attention to the need to build resilient communities and prompted the adoption of disaster resilience policies across communities, cities, and nations. As policies are translated into local actions, policymakers, researchers, and practitioners are advocating for the measurement of disaster resilience as a means to identify areas for improvement, plan interventions, evaluate the effectiveness of resilience strategies, and monitor resilience progress. The need to assess disaster resilience has spawned a growing body of research examining the underlying drivers of resilience and identifying how disaster resilience can be operationalised and measured. In particular, recent research has focused on the importance of social resilience, which is a component of disaster resilience and refers to the capacity of people and communities to deal with external stresses and shocks, and how it contributes to disaster preparedness, disaster response, and post-disaster recovery. However, while local communities are seen as the frontline in preparing for and responding to disasters, the scale of analysis for much of the existing resilience assessments have focused on the city or higher levels of analysis. Questions thus remain about whether these assessment tools are relevant and applicable at the sub-city or neighbourhood level. This thesis seeks to develop social resilience assessment measures for neighbourhoods through integrating scientific and local knowledge. Using an appreciative inquiry approach, a workshop with hazard researchers, practitioners, and a policymaker in Wellington, New Zealand, was first conducted in 2015. This was followed in 2016 by a series of focus groups with stakeholders in five neighbourhoods across the Wellington region in New Zealand, and the City and County of San Francisco in the United States. The workshop and focus groups explored how social resilience is conceptualised, its essential characteristics, and neighbourhood-specific contextual influences that shape social resilience levels. Responses from various stakeholder groups – hazard researcher, emergency practitioner, policymaker, and neighbourhood stakeholder – revealed similarities in how social resilience is perceived. Social resilience is conceptualised as having both cognitive and structural dimensions and is linked to communities’ economic, infrastructural/built, natural, and institutional/governance environments. Cognitive characteristics – those that relate to people’s attitudes, values, and beliefs as well as their mental processes and perceptions of themselves and their environment – include collective efficacy, sense of community and place attachment, decision-making inclusiveness, and unifying leadership at the neighbourhood-level. Structural dimensions relate to discrete features and characteristics of people and communities and include their diversity of skills, education and training; social networks; access to financial resources; and understanding potential hazard risks and impacts. These characteristics form a framework for measuring neighbourhood-level social resilience. Furthermore, these shared characteristics across different stakeholder groups demonstrate the potential universality of social resilience assessment constructs at the neighbourhood level that could inform new models for measuring disaster resilience. They also provide a foundation for local-level stakeholders (e.g., policymakers, practitioners, and community members) who are looking into baselining neighbourhood disaster resilience using an integrated approach. While different stakeholder perspectives contain similarities, this thesis finds that common social resilience characteristics are contextual to individual neighbourhoods, reflecting diversity at this level of analysis. By examining the concept of social capital – one of the social resilience characteristics – three key themes were identified that influence the formation, activation, and benefits of social capital resources: community demography, cultural influences on social support, and neighbourhood governance. An assessment framework was proposed that incorporates both quantitative indicators and contextual questions across six structural dimensions (i.e., population stability, neighbourhood-based organisations and groups, coordination between community-based organisations, linkages to cultural and ethnic minority communities, presence and effectiveness of neighbourhood leaders and community-based organisations, and inclusive and transparent government processes) and four cognitive dimensions (i.e., cultural beliefs and expectations, trust, social support, and empowerment through collective action). Thus, the results of this thesis highlight one important consideration in the development and implementation of resilience assessment tools at this geographic scale. While this research points to potential universality of social resilience assessment constructs and measures, it has also identified the need to consider contextual influences and characteristics when mapping them onto various neighbourhoods

Collapse of the vortex-lattice inductance and shear modulus at the melting transition in untwinned YBa2Cu3O7\rm YBa_2Cu_3O_7

The complex resistivity $\hat{\rho}(\omega)$ of the vortex lattice in an untwinned crystal of 93-K $\rm YBa_2Cu_3O_7$ has been measured at frequencies $\omega/2\pi$ from 100 kHz to 20 MHz in a 2-Tesla field $\bf H\parallel c$, using a 4-probe RF transmission technique that enables continuous measurements versus $\omega$ and temperature $T$. As $T$ is increased, the inductance ${\cal L}_s(\omega) ={\rm Im} \hat{\rho}(\omega)/ \omega$ increases steeply to a cusp at the melting temperature $T_m$, and then undergoes a steep collapse consistent with vanishing of the shear modulus $c_{66}$. We discuss in detail the separation of the vortex-lattice inductance from the `volume' inductance, and other skin-depth effects. To analyze the spectra, we consider a weakly disordered lattice with a low pin density. Close fits are obtained to $\rho_1(\omega)$ over 2 decades in $\omega$. Values of the pinning parameter $\kappa$ and shear modulus $c_{66}$ obtained show that $c_{66}$ collapses by over 4 decades at $T_m$, whereas $\kappa$ remains finite.Comment: 11 pages, 8 figures, Phys. Rev. B, in pres

Microwave and Millimeter Wave Techniques

Contains reports on four research projects.Joint Services Electronics Program (Contract DAAB07-74-C-0630)National Science Foundation (Grant MPS-73-05043-A01

Radio Astronomy

Contains research objectives, summary of research and reports on five research projects.National Aeronautics and Space Administration (Grant NGL 22-009-016)National Aeronautics and Space Administration (Grant NGR 22-009-421)Langley Research Center Contract NASI-10693National Science Foundation (Grants GP-20769)National Science Foundation (Grants GP-21348)National Science Foundation (Grants GP-14589)California Institute of Technology Contract 952568Sloan Fund for Basic Research (M.I.T., Grant 241

Results from Ireland North and South’s 2022 report card on physical activity for children and adolescents

BackgroundThe Ireland North and South Report Card on Physical Activity (PA) for Children and Adolescents aims to monitor progress in PA participation across a range of internationally established indicators.MethodsData were collated for 11 indicators and graded following the harmonised Active Healthy Kids Global Alliance report card process. Six representative studies (sample size range n = 898 to n = 15,557) were primarily used in the grading, with many indicators supplemented with additional studies and reports. Data collected since the implementation of COVID-19 public health measures in March 2020 were excluded.ResultsGrades were awarded as follows: ‘Overall physical activity’, C-; ‘Organised Sport and Physical Activity’, C; ‘Active Play’, INC; ‘Sedentary Behaviours’, C-; ‘Physical Fitness’, INC; ‘Family and Peers’, D+; ‘School’, C-; ‘Physical Education’, D; ‘Community and Environment’, B+ and ‘Government’, B. Separate grades were awarded for disability as follows; ‘Overall physical activity’, F; ‘Organised Sport and Physical Activity’, D; ‘Sedentary Behaviours’, C-; ‘Family and Peers’, C; ‘School’, C- and ‘Government’, B. ‘Active Play’, ‘Physical Fitness’, ‘Physical Education’ and ‘Community and Environment’ were all graded INC for disability. Since the last report card in 2016, four grades remained the same, three increased (‘Overall physical activity’, ‘School’ and ‘Physical Education’) and two (‘Family and Peers,’ and ‘Government’) were awarded grades for the first time.ConclusionGrades specific to children and adolescents with disability were generally lower for each indicator. While small improvements have been shown across a few indicators, PA levels remain low across many indicators for children and adolescents

A Common Variant in the Telomerase RNA Component Is Associated with Short Telomere Length

Background: Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the populationbased Health Aging and Body Composition (Health ABC) Study and in two replication samples (the TwinsUK Study and the Amish Family Osteoporosis Study, AFOS). Methodology: Five variants were identified in the TERC region by sequence analysis and only one SNP was common (rs2293607, G/A). The frequency of the G allele was 0.26 and 0.07 in white and black, respectively. Testing for association between TL and rs2293607 was performed using linear regression models or variance component analysis conditioning on relatedness among subjects. Results: The adjusted mean TL was significantly shorter in 665 white carriers of the G allele compared to 887 non-carriers from the Health ABC Study (4.69±0.05 kbp vs. 4.86±0.04 kbp, measured by quantitative PCR, p = 0.005). This association was replicated in another white sample from the TwinsUK Study (6.90±0.03 kbp in 301 carriers compared to 7.06±0.03 kbp in 395 non-carriers, measured by Southern blots, p = 0.009). A similar pattern of association was observed in whites from the family-based AFOS and blacks from the Health ABC cohort, although not statistically significant, possibly due to the lower allele frequency in these populations. Combined analysis using 2,953 white subjects from 3 studies showed a significant association between TL and rs2293607 (β =-0.19±0.04 kbp, p = 0.001). Conclusion: Our study shows a significant association between a common variant in TERC and TL in humans, suggesting that TERC may play a role in telomere homeostasis. © 2010 Njajou et al

Plasma Dynamics

Contains reports on eight research projects split into two sections.National Science Foundation (Grant ENG79-07047)U.S. Air Force - Office of Scientific Research (Grant AFOSR-77-3143D)U.S. Department of Energy (Contract DE-ACO2-78ET-51013)U.S. Department of Energy (Contract DE-ACO2-78ET-53073.AO02)U.S. Department of Energy (Contract DE-ACO2-78ET-53074)U.S. Department of Energy (Contract DE-ACO2-78ET-53076)U.S. Department of Energy (Contract DE-ACO2-78ET-51002

Genomic Sequencing and Comparative Analysis of Epstein-Barr Virus Genome Isolated from Primary Nasopharyngeal Carcinoma Biopsy

Whether certain Epstein-Barr virus (EBV) strains are associated with pathogenesis of nasopharyngeal carcinoma (NPC) is still an unresolved question. In the present study, EBV genome contained in a primary NPC tumor biopsy was amplified by Polymerase Chain Reaction (PCR), and sequenced using next-generation (Illumina) and conventional dideoxy-DNA sequencing. The EBV genome, designated HKNPC1 (Genbank accession number JQ009376) is a type 1 EBV of approximately 171.5 kb. The virus appears to be a uniform strain in line with accepted monoclonal nature of EBV in NPC but is heterogeneous at 172 nucleotide positions. Phylogenetic analysis with the four published EBV strains, B95-8, AG876, GD1, and GD2, indicated HKNPC1 was more closely related to the Chinese NPC patient-derived strains, GD1 and GD2. HKNPC1 contains 1,589 single nucleotide variations (SNVs) and 132 insertions or deletions (indels) in comparison to the reference EBV sequence (accession number NC007605). When compared to AG876, a strain derived from Ghanaian Burkitt's lymphoma, we found 322 SNVs, of which 76 were non-synonymous SNVs and were shared amongst the Chinese GD1, GD2 and HKNPC1 isolates. We observed 88 non-synonymous SNVs shared only by HKNPC1 and GD2, the only other NPC tumor-derived strain reported thus far. Non-synonymous SNVs were mainly found in the latent, tegument and glycoprotein genes. The same point mutations were found in glycoprotein (BLLF1 and BALF4) genes of GD1, GD2 and HKNPC1 strains and might affect cell type specific binding. Variations in LMP1 and EBNA3B epitopes and mutations in Cp (11404 C>T) and Qp (50134 G>C) found in GD1, GD2 and HKNPC1 could potentially affect CD8+ T cell recognition and latent gene expression pattern in NPC, respectively. In conclusion, we showed that whole genome sequencing of EBV in NPC may facilitate discovery of previously unknown variations of pathogenic significance

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated with poor outcomes. Here, we showed that combined expression of Jak2V617Fand mutant IDH1R132Hor Idh2R140Q induces MPN progression, alters stem/progenitor cell function, and impairs differentiation in mice. Jak2V617FIdh2R140Q–mutant MPNs were sensitive to small-molecule inhibition of IDH. Combined inhibition of JAK2 and IDH2 normalized the stem and progenitor cell compartments in the murine model and reduced disease burden to a greater extent than was seen with JAK inhibition alone. In addition, combined JAK2 and IDH2 inhibitor treatment also reversed aberrant gene expression in MPN stem cells and reversed the metabolite perturbations induced by concurrent JAK2 and IDH2 mutations. Combined JAK2 and IDH2 inhibitor therapy also showed cooperative efficacy in cells from MPN patients with both JAK2mutand IDH2mutmutations. Taken together, these data suggest that combined JAK and IDH inhibition May offer a therapeutic advantage in this high-risk MPN subtype.Damon Runyon Cancer Research Foundation (DRG-2241-15)Howard Hughes Medical Institute (Faculty Scholars Award)Stand Up To CancerNational Cancer Institute (U.S.) (P50CA165962)National Cancer Institute (U.S.) (P30CA14051)Koch Institute for Integrative Cancer Research ( Dana-Farber Harvard Cancer Center Bridge Project)Leukemia & Lymphoma Society of America. Specialized Center of Research (SCOR) ProgramNational Institutes of Health (U.S.) (grant U54OD020355-01)National Institutes of Health (U.S.) (grant NCI R01CA172636)National Institutes of Health (U.S.) (grant R35CA197594)National Cancer Institute (U.S.) (Cancer Center Support Grant (P30 CA008747)

The unmasking of Pneumocystis jiroveci pneumonia during reversal of immunosuppression: Case reports and literature review

Background: Pneumocystis jiroveci pneumonia (PCP) is an important opportunistic infection among immunosuppressed patients, especially in those infected with human immunodeficiency virus (HIV). The clinical presentation of PCP in immunosuppressed patients have been well-reported in the literature. However, the clinical importance of PCP manifesting in the setting of an immunorestitution disease (IRD), defined as an acute symptomatic or paradoxical deterioration of a (presumably) preexisting infection, which is temporally related to the recovery of the immune system and is due to immunopathological damage associated with the reversal of immunosuppressive processes, has received relatively little attention until recently. Case presentation: We aim to better define this unique clinical syndrome by reporting two cases of PCP manifesting acutely with respiratory failure during reversal of immunosuppression in non-HIV infected patients, and reviewed the relevant literature. We searched our databases for PCP cases manifesting in the context of IRD according to our predefined case definition, and reviewed the case notes retrospectively. A comprehensive search was performed using the Medline database of the National Library of Medicine for similar cases reported previously in the English literature in October 2003. A total of 28 non-HIV (excluding our present case) and 13 HIV-positive patients with PCP manifesting as immunorestitution disease (IRD) have been reported previously in the literature. During immunorestitution, a consistent rise in the median CD4 lymphocyte count (28/μL to 125/μL), with a concomitant fall in the median HIV viral load (5.5 log10 copies/ml to 3.1 log10 copies/ml) was observed in HIV-positive patients who developed PCP. A similar upsurge in peripheral lymphocyte count was observed in our patients preceding the development of PCP, as well as in other non-HIV immunosuppressed patients reported in the literature. Conclusions: PCP manifesting as IRD may be more common than is generally appreciated. Serial monitoring of total lymphocyte or CD4 count could serve as a useful adjunct to facilitate the early diagnosis and pre-emptive treatment of this condition in a wide range of immunosuppressed hosts, especially in the presence of new pulmonary symptoms and/or radiographic abnormalities compatible with the diagnosis. © 2004 Wu et al; licensee BioMed Central Ltd.published_or_final_versio