Integral equation for spin dependent unintegrated parton distributions incorporating double ln^2(1/x) effects at low x

In this paper we derive an integral equation for the evolution of unintegrated (longitudinally) polarized quark and gluon parton distributions. The conventional CCFM framework is extended at small x in order to incorporate the QCD expectations concerning the double ln^2(1/x) resummation at low x for the integrated distributions. Complete Altarelli-Parisi splitting functions are included, that makes the formalism compatible with the LO Altarelli-Parisi evolution at large and moderately small values of x. The obtained modified polarized CCFM equation is shown to be partially diagonalized by the Fourier-Bessel transform. Results of the numerical solution for this modified CCFM equation for the non-singlet quark distributions are presented.Comment: 24 pages, 3 figures, LaTeX, some discussion added, none of the results changed, version to appear in Phys. Rev.

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Analysis of Creativity and Fair View in Accounting

Bakalářská práce s názvem Analýza kreativity a věrného obrazu v účetnictví je rozdělena na praktickou a teoretickou část. Teoretická část je zaměřena a podstatu účetních výkazů a jejich nedostatky. Jsou zde teoreticky popsány legální i nelegální způsoby úpravy dat. Praktická část modeluje ve fiktivní společnosti tří rozdílné postupy a porovnává výhodnost jednotlivých postupů.Bachelor thesis called Analysis of Creativity and Fair View in Accounting is divided into practical and theoretical part. The theoretical part is focused on the nature of financial statements and their shortcomings. There are theoretically described legal and illegal ways of data editing. The practical part models three different procedures in a fictitious company and compares the advantages of individual procedures.117 - Katedra účetnictví a danívelmi dobř

Integral Equation for Spin Dependent Unintegrated Parton Distributions Incorporating Double Ln²(1/x) Effects At Low X

In this paper we derive an integral equation for the evolution of unintegrated (longitudinally) polarized quark and gluon parton distributions