Halo Sampling, Local Bias and Loop Corrections

We develop a new test of local bias, by constructing a locally biased halo density field from sampling the dark matter-halo distribution. Our test differs from conventional tests in that it preserves the full scatter in the bias relation and it does not rely on perturbation theory. We put forward that bias parameters obtained using a smoothing scale R can only be applied to computing the halo power spectrum at scales k ~ 1/R. Our calculations can automatically include the running of bias parameters and give vanishingly small loop corrections at low-k. Our proposal results in much better agreement of the sampling and perturbation theory results with simulations. In particular, unlike the standard interpretation of local bias in the literature, our treatment of local bias does not generate a constant power in the low-k limit. We search for extra noise in the Poisson corrected halo power spectrum at wavenumbers below its turn-over and find no evidence of significant positive noise (as predicted by the standard interpretation) while we find evidence of negative noise coming from halo exclusion for very massive halos. Using perturbation theory and our non-perturbative sampling technique we also demonstrate that nonlocal bias effects discovered recently in simulations impact the power spectrum only at the few percent level in the weakly nonlinear regime.Comment: 25 pages, 14 figures; V2: significant revision including more details about halo exclusion and low-k noise. Conclusions unchange

Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: An analysis from the National Health and Wellness Survey.

The aim of this study was to understand the current burden of primary generalized tonic-clonic seizures (PGTCS) associated with idiopathic generalized epilepsy (IGE) as a function of seizure frequency. We analyzed data for (IGE) as a proxy measure of PGTCS. Little is known about the quality of life (QoL), health utility, productivity, healthcare resource utilization (HRU), and cost burden of PGTCS or IGE. Patients were identified from the US (2011, 2012, & 2013), 5EU (2011 & 2013), and Brazil (2011 & 2012) National Health and Wellness Survey, a nationally representative, internet-based survey of adults (18+ years). Patients that self-reported a diagnosis of IGE were categorized into seizure frequencies of: ≥1 seizure per week, 1-3 seizures per month, 1-4 seizures per year, or <1 seizure per year. QoL was measured using the SF-36v2 Mental (MCS) and Physical Component Summary (PCS) scores, health utilities with the SF-6D, productivity with the Work Productivity and Activity Impairment (WPAI) questionnaire, and HRU as reported in the past six months. Unit costs were estimated from the literature and multiplied against HRU values to calculate direct costs and WPAI values to calculate indirect costs. Generalized linear regression was utilized to examine the relationship between seizure frequency and each measure of burden with adjustment for covariates. Out of the general population surveyed, IGE was self-reported in 782 of 176,093 (US), 172 of 30,000 (UK), 106 of 30,001 (Germany), 87 of 30,000 (France), 31 of 12,011 (Spain), 22 of 17,500 (Italy), and 34 of 24,000 (Brazil). Persistent seizures (≥1 per year) were reported in over 40% of patients with IGE (10-15% with ≥1 seizure per week, 10-15% with 1-3 seizures per month, 20-25% with 1-4 seizures per year). Over 75% were treated with antiepileptic drugs (AEDs). Compared with those having <1 seizure per year (reference group), patients in the two most frequent seizure categories reported worse MCS and PCS scores. Patients in the three highest seizure frequency groups consistently reported worse health utility scores, and greater presenteeism (attending work while not physically or mentally capable of working), overall work impairment, activity impairment, HRU, indirect costs, and direct costs than the reference group. Despite the availability of AEDs during the year surveyed, a substantial number of patients experienced persistent seizures. Increasing seizure frequency was clearly associated with worse outcomes. The burden of PGTCS and IGE may be proportionally reduced by newer AEDs which may increase the proportion of seizure-free patients or shift more patients into lower seizure frequency categories

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Scattering of positrons and electrons by alkali atoms

Absolute total scattering cross sections (Q sub T's) were measured for positrons and electrons colliding with sodium, potassium, and rubidium in the 1 to 102 eV range, using the same apparatus and experimental approach (a beam transmission technique) for both projectiles. The present results for positron-sodium and -rubidium collisions represent the first Q sub T measurements reported for these collision systems. Features which distinguish the present comparisons between positron- and electron-alkali atom Q sub T's from those for other atoms and molecules (room-temperature gases) which have been used as targets for positrons and electrons are the proximity of the corresponding positron- and electron-alkali atom Q sub T's over the entire energy range of overlap, with an indication of a merging or near-merging of the corresponding positron and electron Q sub T's near (and above) the relatively low energy of about 40 eV, and a general tendency for the positron-alkali atom Q sub T's to be higher than the corresponding electron values as the projectile energy is decreased below about 40 eV

Secondary organic aerosol (SOA) formation from reaction of isoprene with nitrate radicals (NO_3)

Secondary organic aerosol (SOA) formation from the reaction of isoprene with nitrate radicals (NO3) is investigated in the Caltech indoor chambers. Experiments are performed in the dark and under dry conditions (RH<10%) using N2O5 as a source of NO3 radicals. For an initial isoprene concentration of 18.4 to 101.6 ppb, the SOA yield (defined as the ratio of the mass of organic aerosol formed to the mass of parent hydrocarbon reacted) ranges from 4.3% to 23.8%. By examining the time evolutions of gas-phase intermediate products and aerosol volume in real time, we are able to constrain the chemistry that leads to the formation of low-volatility products. Although the formation of ROOR from the reaction of two peroxy radicals (RO2) has generally been considered as a minor channel, based on the gas-phase and aerosol-phase data it appears that RO2+RO2 reaction (self reaction or cross-reaction) in the gas phase yielding ROOR products is a dominant SOA formation pathway. A wide array of organic nitrates and peroxides are identified in the aerosol formed and mechanisms for SOA formation are proposed. Using a uniform SOA yield of 10% (corresponding to Mo≅10 μg m−3), it is estimated that ~2 to 3 Tg yr−1 of SOA results from isoprene + NO3. The extent to which the results from this study can be applied to conditions in the atmosphere depends on the fate of peroxy radicals (i.e. the relative importance of RO2+RO2 versus RO2+NO3 reactions) in the nighttime troposphere

Effect of NOx level on secondary organic aerosol (SOA) formation from the photooxidation of terpenes

Secondary organic aerosol (SOA) formation from the photooxidation of one monoterpene (α-pinene) and two sesquiterpenes (longifolene and aromadendrene) is investigated in the Caltech environmental chambers. The effect of NOx on SOA formation for these biogenic hydrocarbons is evaluated by performing photooxidation experiments under varying NOx conditions. The NOx dependence of α-pinene SOA formation follows the same trend as that observed previously for a number of SOA precursors, including isoprene, in which SOA yield (defined as the ratio of the mass of organic aerosol formed to the mass of parent hydrocarbon reacted) decreases as NOx level increases. The NOx dependence of SOA yield for the sesquiterpenes, longifolene and aromadendrene, however, differs from that determined for isoprene and α-pinene; the aerosol yield under high-NOx conditions substantially exceeds that under low-NOx conditions. The reversal of the NOx dependence of SOA formation for the sesquiterpenes is consistent with formation of relatively low-volatility organic nitrates, and/or the isomerization of large alkoxy radicals leading to less volatile products. Analysis of the aerosol chemical composition for longifolene confirms the presence of organic nitrates under high-NOx conditions. Consequently the formation of SOA from certain biogenic hydrocarbons such as sesquiterpenes (and possibly large anthropogenic hydrocarbons as well) may be more efficient in polluted air

Radiation from a uniformly accelerating harmonic oscillator

We consider a radiation from a uniformly accelerating harmonic oscillator whose minimal coupling to the scalar field changes suddenly. The exact time evolutions of the quantum operators are given in terms of a classical solution of a forced harmonic oscillator. After the jumping of the coupling constant there occurs a fast absorption of energy into the oscillator, and then a slow emission follows. Here the absorbed energy is independent of the acceleration and proportional to the log of a high momentum cutoff of the field. The emitted energy depends on the acceleration and also proportional to the log of the cutoff. Especially, if the coupling is comparable to the natural frequency of the detector ($e^2/(4m) \sim \omega_0$) enormous energies are radiated away from the oscillator.Comment: 26 pages, 1 eps figure, RevTeX, minor correction in grammar, add a discussio

Li+ alumino-silicate ion source development for the Neutralized Drift Compression Experiment (NDCX-II)

To heat targets to electron-volt temperatures for the study of warm dense matter with intense ion beams, low mass ions, such as lithium, have an energy loss peak (dE/dx) at a suitable kinetic energy. The Heavy Ion Fusion Sciences (HIFS) program at Lawrence Berkeley National Laboratory will carry out warm dense matter experiments using Li{sup +} ion beam with energy 1.2-4 MeV in order to achieve uniform heating up to 0.1-1 eV. The accelerator physics design of Neutralized Drift Compression Experiment (NDCX-II) has a pulse length at the ion source of about 0.5 {micro}s. Thus for producing 50 nC of beam charge, the required beam current is about 100 mA. Focusability requires a normalized (edge) emittance {approx}2 {pi}-mm-mrad. Here, lithium aluminosilicate ion sources, of {beta}-eucryptite, are being studied within the scope of NDCX-II construction. Several small (0.64 cm diameter) lithium aluminosilicate ion sources, on 70%-80% porous tungsten substrate, were operated in a pulsed mode. The distance between the source surface and the mid-plane of the extraction electrode (1 cm diameter aperture) was 1.48 cm. The source surface temperature was at 1220 C to 1300 C. A 5-6 {micro}s long beam pulsed was recorded by a Faraday cup (+300 V on the collector plate and -300 V on the suppressor ring). Figure 1 shows measured beam current density (J) vs. V{sup 3/2}. A space-charge limited beam density of {approx}1 mA/cm{sup 2} was measured at 1275 C temperature, after allowing a conditioning time of about {approx} 12 hours. Maximum emission limited beam current density of {ge} 1.8mA/cm{sup 2} was recorded at 1300 C with 10-kV extractions. Figure 2 shows the lifetime of two typical sources with space-charge limited beam current emission at a lower extraction voltage (1.75 kV) and at temperature of 1265 {+-} 7 C. These data demonstrate a constant, space-charge limited beam current for 20-50 hours. The lifetime of a source is determined by the loss of lithium from the alumino-silicate material either as ions or as neutral atoms. Our measurements suggest that for the low duty factor ({approx}10{sup -8}) required for NDCX-II, the lifetime of an emitter depends mostly on the duration that the emitter spends at elevated temperature, that is, at {ge} 1250 C. At this temperature, lithium loss is due mostly to neutral loss (not charged ion extraction). Extension of the lifetime of the source may be possible by lowering the temperature between beam pulses, when the idling time is sufficiently long between shots. The NDCX-II design seeks to operate the ion source at the maximum current density without running into heat management and lifetime problems. In preparation to fabricate a large (10.9 cm in diameter) source for the NDCXII experiment, recently a 7.6 cm diameter source has been fabricated. The method of fabrication of this larger source is similar to that of fabrication of a 6.3mm diameter source, except a longer furnace heating time was used due to mass differences. NDCX-II construction is in progress. Progress of lithium source study for NDCX-II is available in literature

Understanding the burden of focal epilepsy as a function of seizure frequency in the United States, Europe, and Brazil.

To understand the current burden of focal epilepsy (FE) as a function of seizure frequency. Patients were identified from the United States (2011, 2012, and 2013), five European countries (EU; France, Germany, Italy, Spain, United Kingdom) (2011 and 2013), and Brazil (2011 and 2012) National Health and Wellness Survey (NHWS), a nationally representative, Internet-based survey of adults (18+ years). The NHWS collected data on respondents' quality of life (QoL), health utilities, productivity loss, and healthcare resource utilization. Indirect and direct costs were calculated from the literature. Altogether, 345 of 176,093 (U.S.A.), 73 of 30,000 (United Kingdom), 53 of 30,001 (Germany), 53 of 30,000 (France), 41 of 12,011 (Spain), 37 of 17,500 (Italy), and 71 of 24,000 (Brazil) respondents self-reported a diagnosis of FE. Many respondents (U.S.A.: 56.2%; 5EU: 41.6%; Brazil + 5EU: 40.5%) reported persistent seizures (≥1 per year). Over 60% to just over 71% of respondents with FE were treated with antiepileptic drugs (AEDs). In the United States, seizure frequency was associated with hospitalizations, indirect costs (ages 18-60), and total direct costs. For the 5EU and Brazil + 5EU, seizure frequency was associated with physical QoL, health utilities, activity impairment, and emergency room (ER) visits. Additional associations were observed for the 5EU on hospitalizations, indirect costs (ages 18-60), ER visit costs, and total direct costs and for Brazil + 5EU on absenteeism, overall work impairment, and provider visits. Costing was not performed for Brazil + 5EU. Around half of the patients had persistent seizures despite most taking an AED in this 2011-2013 dataset. The results support the hypothesis that reducing seizures can improve productivity and reduce resource utilization and associated costs. Regional differences may reflect differences in healthcare systems and selected patient populations. Overall, the results suggest that additional treatment options are needed to improve seizure control and reduce related costs