Beer multinationals supporting Africa's development?

This paper addresses the question how partnerships include smallholders into sorghum-beer supply chains. Introduction Restrictions on the import of barley malt by the Nigerian government in the 1980s have facilitated an import substitution strategy that is now widely adopted by the African brewing industry. Barley malt is a key resource for beer brewing. Due to the Nigerian import ban, it was discovered that locally produced sorghum could serve as an adequate substitute for barley (Ogun, 1995). At present, all major brewers on the African continent partially substitute imported barley by sorghum and other locally produced crops, because they are cheaper and do not entail currency losses (Lapper, 2010; Wiggens, 2008). The African informal market of artisanal beers, wines and other drinks made from local ingredients, such as sorghum, is estimated to be four times bigger than the formal sector, and has a value of about US$ 3 billion. Heineken, Guinness and SABMiller now compete with this African home brew market (Capell, 2009). The shift to local resources serves as an incentive for the development of local supply chains that could stimulate agricultural production in Africa. However, such chains are not easily created. In Sub-Saharan Africa, the sorghum grain (Sorghum bicolor) is grown in unpredictable ‘rain-fed’ agriculture contexts, while farmers cannot afford the use of additional inputs. With 300 kg/ha the productivity of African sorghum farming is far below yields in other regions of the world that may reach 9000 kg/ha (ICRISAT, 2008). In 2001, Guinness Ghana tried to set up a sorghum supply chain in Northern Ghana, but failed completely. The company had facilitated farmers in acquiring fertilizer, agrochemicals, as well as certified seeds of a new sorghum variety Kapaala, but had to reject most of the grain one year later because of low quality (Kudadje 2006). The harsh climate and limitations in the institutional business environment hindered the African farmers to integrate into a modern value chain

First-Principles Theoretical Studies of Bulk, Defect and Interface properties of Oxide Semiconductors

Oxide semiconductors have been shown to exhibit rich physics related to their bulk, defect and interface properties. First-principles calculations have and will continue to play a major role in developing an understanding of the microscopic origins of these phenomena. In this thesis, first-principles studies are presented for several oxide semiconductors, with a view to understand how their microscopic properties ultimately determine device functionality. In Chapter 3, a detailed study of bulk SrZrO3 and Sr(Ti,Zr)O3 alloys is performed. For Sr(Ti,Zr)O3 alloys with 50% Ti concentration, we find that arranging the Ti and Zr atoms into a 1×1 SrZrO3/SrTiO3 superlattice along the [001] direction leads to breaking of the conduction band t2g orbital degeneracy, which could suppress scattering due to electron-phonon interactions. In Chapter 4, we present an investigation into the properties of native defects and hydrogen in SrZrO3. It is found that oxygen and strontium vacancies are the dominant defects in the absence of impurity doping, and will form deep donor and deep acceptor states, respectively. Hydrogen is found to be amphoteric in this material at different lattice sites; additionally, this impurity forms a stable complex with oxygen vacancies. In Chapter 5, the tendency for ABO3 perovskite oxides with 3dn B-cations to exhibit ferroelectricity and multiferroicity is investigated. Using the LaBO3 series as a model, we find that initially, as electrons are added to the B-cation d orbital, the tendency for the system to exhibit a ferroelectric distortion disappears - however, for high spin d5 - d7 and d8 cations a strong ferroelectric instability is recovered, and this effect is explained within the pseudo Jahn-Teller theory for ferroelectricity. This finding provides a new route for the design of strongly coupled magnetoelectric materials. In Chapters 6 and 7 the fundamental properties of the technologically important oxide heterostructure systems ZnO/MgZnO and SrTiO3/LaAlO3 are characterized. For the latter, we identify a previously unreported mechanism for interface induced magnetism based on surface aluminium vacancies, which will aid in interpreting experimental results for this system and other polar/non-polar oxide heterostructures

Why people do not keep their promise: Understanding the pro-environmental behavior in China

The promise-implementation gap is a particularly salient feature in promoting individuals' pro-environmental behavior (PEB). Many individuals are becoming aware that their past behavior has not actually been in line with the norms they have made promise to. Prior studies have suggested an array of constraints restricting individuals' pro-environmental involvement. In addition to individuals' behavioral incapability, the said inconsistency can also be traced back to the affected willingness, hard trade-off decisions, and/or the failure of stakeholders' collaboration. Based on the line of reasoning, this research develops an attitude model and frames the potential types of gaps from the perspective of attitude formation and transition surrounding PEBs. The promise-implementation gap is closely related to a sequence of attitudes showing great motivation differences from being reactive to reactive-active transition and to the active-proactive transition. The paper contextualizes the model to examine the promise-implementation gap in the Chinese environmental context. Importance of this context is high with quite mixed economic and social development across the country, which is the same across the world. The application of the model in the Chinese context justifies the validity and generalizability of the theoretic framework. The paper contributes a novel understanding of the promise-implementation gap, and illuminates potential analytic measures and managerial implications for literature of this stream

Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

EMR2/ADGRE2 is a human myeloid-restricted adhesion G protein-coupled receptor critically implicated in vibratory urticaria, a rare type of allergy caused by vibration-induced mast cell activation. In addition, EMR2 is also highly expressed by monocyte/macrophages and has been linked to neutrophil migration and activation. Despite these findings, little is known of EMR2-mediated signaling and its role in myeloid biology. In this report, we show that activation of EMR2 via a receptor-specific monoclonal antibody promotes the differentiation of human THP-1 monocytic cell line and induces the expression of pro-inflammatory mediators, including IL-8, TNF-α, and MMP-9. Using specific signaling inhibitors and siRNA knockdowns, biochemical and functional analyses reveal that the EMR2-mediated signaling is initiated by Gα16, followed by the subsequent activation of Akt, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and nuclear factor kappa-light-chain-enhancer of activated B cells. Our results demonstrate a functional role for EMR2 in the differentiation and inflammatory activation of human monocytic cells and provide potential targets for myeloid cell-mediated inflammatory disorders

CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40

Secondary T cell responses are enhanced because of an expansion in numbers of antigen-specific (memory) cells. Using major histocompatibility complex class II tetramers we have tracked peptide-specific endogenous (non–T cell receptor transgenic) CD4 memory T cells in normal and in costimulation-deficient mice. CD4 memory T cells were detectable after immunization for more than 200 days, although decay was apparent. Memory cells generated in CD40 knockout mice by immunization with peptide-pulsed wild-type dendritic cells survived in the absence of CD40 and proliferated when boosted with peptide (plus adjuvant) in a CD40-independent fashion. However, differentiation of the memory cells into cytokine-producing effector cells did not occur in the absence of CD40. The data indicate that memory cells can be generated without passing through the effector cell stage

Taking Charge of Systemic Sclerosis: A Pilot Study to Assess the Effectiveness of an Internet Self‐Management Program

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106842/1/acr22192.pd

Direct Awards in Germany – Design And Effects

Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

Randomized feasibility trial of the Scleroderma Patient-centered Intervention Network hand exercise program (SPIN-HAND): study protocol

Background: Significant functional impairment of the hands is nearly universal in systemic sclerosis (SSc, scleroderma). Hand exercises may improve hand function, but developing, testing and disseminating rehabilitation interventions in SSc is challenging. The Scleroderma Patient-centered Intervention Network (SPIN) was established to address this issue and has developed an online hand exercise program to improve hand function for SSc patients (SPIN-HAND). The aim of the proposed feasibility trial is to evaluate the feasibility of conducting a full-scale randomized controlled trial (RCT) of the SPIN-HAND intervention. Design and methods: The SPIN-HAND feasibility trial will be conducted via the SPIN Cohort. The SPIN Cohort was developed as a framework for embedded pragmatic trials using the cohort multiple RCT design. In total, 40 English-speaking SPIN Cohort participants with at least mild hand function limitations (Cochin Hand Function Scale ≥3) and an indicated interest in using an online hand-exercise intervention will be randomized with a 1:1 ratio to be offered to use the SPIN-HAND program or usual care for 3 months. The primary aim is to evaluate the trial implementation processes, required resources and management, scientific aspects, and participant acceptability and usage of the SPIN-HAND program. Discussion: The SPIN-HAND exercise program is a self-help tool that may improve hand function in patients with SSc. The SPIN-HAND feasibility trial will ensure that trial methodology is robust, feasible, and consistent with trial participant expectations. The results will guide adjustments that need to be implemented before undertaking a full-scale RCT of the SPIN-HAND program. Trial registration: ClinicalTrials.gov Identifier: NCT03092024.Canadian Institutes of Health Research(undefined