Поняття автономії індивіда: на перетині політичної теорії лібералізму та ідеї ліберальної освіти (The Concept of Individual Autonomy: on the Intercross Between Political Theory of Liberalism and the Idea of Liberal Education)

У статті розглядається поняття індивідуальної автономії в контексті множини відношень між лібе- ральною освітою та політичним лібералізмом. Здійснюється спроба фундаментальної критики проектів по- будови субстантивної метамоделі індивідуальної автономії з позицій соціального конструктивізму та розу- міння людини як істоти, здатної до постійної трансценденції поза власні межі. (Numerous versifications of liberalism theories and liberal education projects encompass the common ideal of recognizing the liberty as an ultimate value. The article starts it argumentation with the idea that the common for the both projects general concept of liberty is empty, unless the philosophical anthropology foundations that establish it are clarified. In the other words, the content of the concept of «liberty» should be considered as derivation out of a specific philosophical anthropology project that justifies its value, describes its sense, defines limitations, provides criteria of its realization. In this sense the idea of liberal education is thematically broader than political liberalism projects. Regarding the liberal education in the context of liberalism as a political theory, the situation changes. This situation is being examined from the standpoint of system theory and implications from metamodel of socioolitical fabric as it posed by liberalism theorists. Considering the concept of individual autonomy that is stated to be the aim of liberal education, a special attention is given to an attempt of fundamental critique against the projects that aim to propose a substantive metamodel of individual autonomy. This critique is based upon social constructivism approach and treating a human being as the one who is potentially capable for constant transcendence its own limitations. Finally, in a rather descriptive way it is proposed a normative interpretation of what the individual autonomy might be, finding the argumentation for it in Sufi tradition and intuitions of I. Berlin.

Unemployment and portfolio choice: Does persistence matter?

We use a life cycle model of consumption and portfolio choice to study the effects of social security on the investment decisions of households for the European case. Our model is mainly based on the one developed by Cocco, Gomes, and Maenhout (2005). We extend it by unemployment risk using Markov chains to model the transition between different employment states. In contrast to most models in the life cycle literature, our model allows for three different states, namely employment, short-term as well as long-term unemployment. This allows us to examine the effects of persistence in the unemployment process on portfolio choice. Our main findings are, first, that in case of short-term unemployment only, social security systems as those established in the EU are able to offset the negative impact of unemployment risk on the portfolio-share invested in risky assets. Second, the simulation results reveal that when allowing for long-term unemployment the equity-share is suppressed, especially for young investors. We show that this negative effect of unemployment is mainly driven by its persistence

Effective lining of tunnel kiln cars made of aluminosilicate ceramoconcrete

Aluminosilicate ceramoconcrete lining for cars used in ceramic plant firing kilns was developed and introduced. The first cars with this lining have already operated for more than 50 cyclesyesBelgorod State Universit

Pharmacokinetic Interaction Between Valproic Acid, Meropenem, and Risperidone.

Pharmacokinetic Interaction Between Valproic Acid, Meropenem, and Risperidon

Switching antipsychotics to partial dopamine D2-agonists in individuals affected by schizophrenia: a narrative review.

The aim of this review is to analyse the literature regarding studies centred on the clinical outcome of individuals affected by schizophrenia and treated with various antipsychotics, and then switched to orally administered partial D2-dopamine agonists (PD2A): Aripiprazole (ARI), brexpiprazole (BREX) or cariprazine (CARI). A PubMed literature search was performed on 16 February 2021, and updated on Jan 26, 2022 for literature on antipsychotic switching in individuals affected by schizophrenia. Literature was included from 2002 onward. Six strategies were defined: Abrupt, gradual and cross-taper switch, and 3 hybrid strategies. The primary outcome was all-cause discontinuation rate per switch strategy per goal medication. In 10 reports on switching to ARI, 21 studies with different strategies were described, but there were only 4 reports and 5 strategies on switching to BREX. Only one study about CARI was included, but it was not designed as a switch study. The studies are difficult to compare due to differences in methodology, previous antipsychotic medication, doses of the introduced P2DA and study duration. This analysis did not reveal evidence for a preferable switching strategy. A protocol should be developed which defines optimal duration, instruments to be used, and the timing of the exams.KEY MESSAGESMost switch studies on partial D2-agonists focus on ARI, with only a few on BREX, while little is known about the clinical outcome of switching individuals to CARIThere is a wide variation of possible switch methods: Abrupt switch - gradual switch - cross-tapering switch - hybrid strategies including plateau switchThe protocols used differ considerably between the studies. A strict comparison between the studies is difficult, for which reason the present evidence does not support an unambiguous preference for a particular switch strategy.From a methodological point of view, a standardised clinical protocol should be developed to allow comparisons between studies regarding the clinical outcome of individuals switched from one antipsychotic drug to another

Regulation of multimers via truncated isoforms: a novel mechanism to control nitric-oxide signaling

Nitric oxide (NO) is an essential regulator of Drosophila development and physiology. We describe a novel mode of regulation of NO synthase (NOS) function that uses endogenously produced truncated protein isoforms of Drosophila NOS (DNOS). These isoforms inhibit NOS enzymatic activity in vitro and in vivo, reflecting their ability to form complexes with the full-length DNOS protein (DNOS1). Truncated isoforms suppress the antiproliferative action of DNOS1 in the eye imaginal disc by impacting the retinoblastoma-dependent pathway, yielding hyperproliferative phenotypes in pupae and adult flies. Our results indicate that endogenous products of the dNOS locus act as dominant negative regulators of NOS activity during Drosophila development

OBESITY AS A SPECIFIC OBSTACLE SUSTAINABLE SOCIAL AND ECONOMIC DEVELOPMENT

Аnnotation. At present, significant growth in the number of persons suffering from overweight is a serious problem for sustainable socio-economic development at the state, regional and municipal levels. In this regard great scientific and practical importance is the improvement of the methodology for applied studies of the extent and prevalence of obesity, as well as of losses caused by the deepening of such a negative process

THE FEATURES OF STATISTICAL CHARACTERISTICS TERRORISM ON TRANSPORT

Terrorism in transport as a special type of terrorism has in fact become a multifaceted and rapidly spreading phenomenon of modern social life, which cannot and should not remain outside the field of statistical science and practice. It is unlikely that a statistical estimate of transport terrorism can be derived from one or more private indicators. This is likely to require a system of statistical indicators, where individual elements occupy a well-defined place and complement each other consistently. In this case, the number of terrorist acts committed in public transport, for a certain period of time or a year, as well as the damage caused to society should be taken into account

OBESITY AS A SPECIFIC OBSTACLE SUSTAINABLE SOCIAL AND ECONOMIC DEVELOPMENT

Аnnotation. At present, significant growth in the number of persons suffering from overweight is a serious problem for sustainable socio-economic development at the state, regional and municipal levels. In this regard great scientific and practical importance is the improvement of the methodology for applied studies of the extent and prevalence of obesity, as well as of losses caused by the deepening of such a negative process