High-resolution SNP array analysis of patients with developmental disorder and normal array CGH result (vol 13, 84, 2012)

Peer reviewe

Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes : The PREDO Study

Background We investigated whether maternal prenatal emotions are associated with gestational length and birth weight in the large PREDO Study with multiple measurement points of emotions during gestation. Methods Altogether 3376 pregnant women self-assessed their positive affect (PA, Positive and Negative Affect Schedule) and depressive (Center for Epidemiologic Studies Depression Scale, CES-D) and anxiety (Spielberger State Anxiety Scale, STAI) symptoms up to 14 times during gestation. Birth characteristics were derived from the National Birth Register and from medical records. Results One standard deviation (SD) unit higher PA during the third pregnancy trimester was associated with a 0.05 SD unit longer gestational length, whereas one SD unit higher CES-D and STAI scores during the third trimester were associated with 0.04-0.05 SD unit shorter gestational lengths (P-values = 42 weeks), birth weight and fetal growth were not associated with maternal prenatal emotions. Conclusions This study with 14 measurements of maternal emotions during pregnancy show modest effects of prenatal emotions during the third pregnancy trimester, particularly in the weeks close to delivery, on gestational length. From the clinical perspective, the effects were negligible. No associations were detected between prenatal emotions and birth weight.Peer reviewe

High-resolution SNP array analysis of patients with developmental disorder and normal array CGH results

Erratum to: high-resolution SNP array analysis of patients with developmental disorder and normal array CGH result BMC Medical Genetics 2014, 15:124 10.1186/s12881-014-0124-3Peer reviewe

Characteristics of the participants of the Predo-Study.

<p>Characteristics of the participants of the Predo-Study.</p

The associations between prenatal positive affect, depressive and anxiety symptoms with birth outcome.

<p>The associations between prenatal positive affect, depressive and anxiety symptoms with birth outcome.</p

Maternal Prenatal Positive Affect, Depressive and Anxiety Symptoms and Birth Outcomes: The PREDO Study - Fig 1

<p>Trajectories of maternal (A) positive affect (PANAS), (B) depressive symptoms (CES-D), and (C) anxiety symptoms (STAI) at two-week intervals according to preterm (≤ 36 6/7 gestational weeks), term (37 0/7-41 6/7 gestational weeks) and post-term delivery (≥ 42 0/7 gestational weeks).</p