OC-0483: ISIORT-Europe Data Registry: main characteristics of IORT treatments

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The Gordon-Haus effect for modified NLS solitons

Random jitter in the soliton arrival time (the Gordon-Haus effect) is analyzed for solitons being solutions of the integrable modified nonlinear Schroedinger equation. It is shown that the mean square fluctuation of the soliton position depends on the soliton parameters which can be properly adjusted to suppress the Gordon-Haus jitter.Comment: LaTeX, 7 pages, 3 figures, to be published in Europhys. Let

Spin Properties of Germanium-Vacancy Centers in Bulk and Near-Surface Regions of Diamond

Germanium-vacancy (GeV) centers are now studied extensively due to perspectives of their applications in quantum information processing, nanometrology and nanoscale magnetic resonance imaging. One of the important requirements for these applications is a detailed understanding of the hyperfine interactions in such systems. Quantum chemistry simulation of the negatively charged GeV− color center in diamond is the primary goal of this paper in which we present preliminary results of computer simulation of the bulk H-terminated cluster C6969[GeV−]H8484, as well as of the surface cluster C6464[GeV−]H6868_(100)_H1111 having one dangling bond at (1 0 0) surface using the DFT/PW91/RI/def2-SVP level of theory

Patterns of practice of regional nodal irradiation in breast cancer: results of the European Organization for Research and Treatment of Cancer (EORTC) NOdal Radiotherapy (NORA) survey†

Predicting breast cancer outcome based on SLN node status without ALND is currently an area of uncertainty in SLN+ patients. These uncertainties influence the decision-making of adjuvant nodal irradiation. The NORA Survey was designed to examine the patterns of RNI practice in Europe to provide a basis for designing future trials in areas of equipoise in clinical decision-making concerning RN

Resolution of Mild Ganciclovir-Resistant Cytomegalovirus Disease with Reduced-Dose Cidofovir and CMV-Hyperimmune Globulin

Ganciclovir-resistant cytomegalovirus (CMV) is associated with significant morbidity in solid organ transplant recipients. Management of ganciclovir-resistant CMV may be complicated by nephrotoxicity which is commonly observed with recommended therapies and/or rejection induced by “indirect” viral effects or reduction of immunosuppression. Herein, we report a series of four high serologic risk (donor CMV positive/recipient CMV negative) kidney transplant patients diagnosed with ganciclovir-resistant CMV disease. All patients initially developed “breakthrough” viremia while still receiving valganciclovir prophylaxis after transplant and were later confirmed to exhibit UL97 mutations after failing to eradicate virus on adequate dosages of valganciclovir. The patients were subsequently and successfully treated with reduced-dose (1-2 mg/kg) cidofovir and CMV-hyperimmune globulin, given in 2-week intervals. In addition, all patients exhibited stable renal function after completion of therapy, and none experienced acute rejection. The combination of reduced-dose cidofovir and CMV-hyperimmune globulin appeared to be a safe and effective regimen in patients with mild disease due to ganciclovir-resistant CMV

АСПРЕДЕЛЕНИЕ НАЧАЛЬНОЙ ИОНИЗАЦИИ В РАБОЧЕМ ОБЪЕМЕ ИОНИЗАЦИОННОЙ КАМЕРЫ

The task of a spatial distribution of ion pairs in the active volume of the ionization fission chamber has been studied. The formula of a spatial distribution of ion pairs in cylindrical fission chambers, in which a fissile material layer is coated on the internal side of the external electrode, is derived. It is calculated in two ways: counting the number of ion pairs created in the infinitesimal volume inside the active volume of the chamber by all the trajectories, which emanate from a radiator. In the first case, the infinitesimal volume is a sphere. In the second case, it is arbitrary in shape. The formula has evaluated correctly the density of ion pairs at any point in the active volume of the fission chamber. The dependence of the initial density of ion pairs on a radial distance to a radiator created a typical fission fragment – ion Sr in the center of the chamber and the spatial distribution of the initial density of ion pairs along the chamber have been studied. Рассмотрен вопрос о пространственном распределении пар ионов в рабочем объеме цилиндрической ионизационной камеры деления. Предложена формула для пространственного распределения начальной ионизации в цилиндрической камере деления, в которой слой делящегося вещества нанесен на внутреннюю сторону внешнего электрода. Формула выведена двумя способами: путем подсчета числа пар ионов, генерированных в бесконечно малом объеме внутри рабочего объема камеры всеми треками, исходящими из радиатора. В первом случае бесконечно малый объем имеет форму сферы, во втором – произвольную форму. Формула, полученная без всяких ограничений на направление вылета осколков деления, дает правильное поведение пространственного распределения начальной ионизации как вблизи поверхности радиатора, так и вдали от него. Исследована зависимость начальной плотности ионизации от радиального расстояния до радиатора, создаваемой типичным фрагментом деления – ионом Sr в центре камеры. Исследовано также пространственное распределение начальной плотности ионизации вдоль камеры.