地域で生活している５５歳以上の方の慢性疾患，年齢の捉え方，睡眠の質，健康関連QOL，日常生活行動との関係性

Japan’s aging population rate is increasing and healthy life expectancy has decreases by 10 years shorter than average life expectancy. The aim of this study is to determine the relationship among chronic disease, sleep quality, health-related quality of life (HRQOL), and activities of daily living in people over 55 years old who live in the community. Subjects were 161 persons aged 57 to 90 years who were treated with chronic disease in the outpatient department of the A hospital. Exclusion criteria included patients with dementia, cancer and severe heart disease. The survey evaluation questionnaires included the Pittsburgh Sleep Quality Index (PSQI), HRQOL by Short-Form 8 Health Survey (SF-8), and activities of daily living. Variables associated with quality of sleep, HRQOL in univariate analysis with p < 0.05 were entered into multivariate analysis using logistic regression with a stepwise forward selection procedure to determine independent variables and their association with major causes. The logistic regression analysis was done using SPSS software and the post-hoc power of the study was estimated using G*power. The level of significance was set at p < 0.05. The risk factor of poor sleep quality was because of history of cancer [odds ratio (OR): 3.53, 95% confidence interval (CI): 1.06 - 11.77], and insomnia (OR: 3.25, 95% CI: 1.55 - 6.79). The risk factors of poor physical HRQOL were motor disease (OR: 2.62, 95% CI: 1.36 - 5.07), respiratory disease (OR: 3.24, 95% CI: 1.27 - 8.26) and having pain (OR: 11.71, 95% CI: 5.35 - 25.66). In addition, anemia was found to be a risk factor of poor mental HRQOL (OR: 4.87, 95% CI: 1.11 - 21.33). The feeling-for-their-body-age (OR: 0.30, 95% CI: 0.15-0.59) was as “younger than actual age” and advanced the risk factor of poor sleep quality. In addition, feeling-for-their-age (OR: 0.44, 95% CI: 0.21 - 0.92) resulted in reduced risk factor of poor physical HRQOL. The risk factor of poor sleep quality was due to a patient with history of cancer. The factor for good sleep quality and the good factor for physical HRQOL were indications of feeling younger than the actual age

地域で生活している５５歳以上の方の慢性疾患，年齢の捉え方，睡眠の質，健康関連QOL，日常生活行動との関係性

Japan’s aging population rate is increasing and healthy life expectancy has decreases by 10 years shorter than average life expectancy. The aim of this study is to determine the relationship among chronic disease, sleep quality, health-related quality of life (HRQOL), and activities of daily living in people over 55 years old who live in the community. Subjects were 161 persons aged 57 to 90 years who were treated with chronic disease in the outpatient department of the A hospital. Exclusion criteria included patients with dementia, cancer and severe heart disease. The survey evaluation questionnaires included the Pittsburgh Sleep Quality Index (PSQI), HRQOL by Short-Form 8 Health Survey (SF-8), and activities of daily living. Variables associated with quality of sleep, HRQOL in univariate analysis with p < 0.05 were entered into multivariate analysis using logistic regression with a stepwise forward selection procedure to determine independent variables and their association with major causes. The logistic regression analysis was done using SPSS software and the post-hoc power of the study was estimated using G*power. The level of significance was set at p < 0.05. The risk factor of poor sleep quality was because of history of cancer [odds ratio (OR): 3.53, 95% confidence interval (CI): 1.06 - 11.77], and insomnia (OR: 3.25, 95% CI: 1.55 - 6.79). The risk factors of poor physical HRQOL were motor disease (OR: 2.62, 95% CI: 1.36 - 5.07), respiratory disease (OR: 3.24, 95% CI: 1.27 - 8.26) and having pain (OR: 11.71, 95% CI: 5.35 - 25.66). In addition, anemia was found to be a risk factor of poor mental HRQOL (OR: 4.87, 95% CI: 1.11 - 21.33). The feeling-for-their-body-age (OR: 0.30, 95% CI: 0.15-0.59) was as “younger than actual age” and advanced the risk factor of poor sleep quality. In addition, feeling-for-their-age (OR: 0.44, 95% CI: 0.21 - 0.92) resulted in reduced risk factor of poor physical HRQOL. The risk factor of poor sleep quality was due to a patient with history of cancer. The factor for good sleep quality and the good factor for physical HRQOL were indications of feeling younger than the actual age

High-resolution Quaternary record of marine organic carbon content in the hemipelagic sediments of the Japan Sea from bromine counts measured by XRF core scanner

Abstract The marine organic carbon content in sediments is a useful tool for reconstructing past productivity in the ocean. Bromine has been proposed as a useful proxy for marine organic carbon, since bromine is more concentrated in marine organic matter compared to terrestrial organic matter. Here, we present a high-resolution Quaternary record of marine organic carbon in the hemipelagic sediments of the Japan Sea obtained during Integrated Ocean Drilling Program (IODP) Expedition 346. We measured the bromine content in the sediments using an XRF core scanner (ITRAX). The total organic carbon content, total nitrogen, and stable carbon isotope values were also measured for discrete samples from the same sediments. The total organic carbon/total nitrogen ratio and the stable carbon isotope ratio of the total organic carbon are used to estimate the marine organic carbon content within the total organic carbon. The Br counts and marine organic carbon content show a high correlation, which we used to construct a calibration equation of the marine organic carbon content from the Br counts. Using the calibration equation, we reconstructed the changes in the marine organic carbon content during the Quaternary with a time resolution of ~ 50 years using sediment cores from IODP Site U1424 in the east central Japan Sea. The method to estimate the marine organic carbon content from the Br counts measured by the XRF core scanner proposed in this paper will be a useful tool to reconstruct the organic carbon content with high resolution and high speed

Epigallocatechin Gallate Stabilized by Cyclodextrin Inactivates Influenza Virus and Human Coronavirus 229E

Natural products are attractive antiviral agents because they are environment-friendly and mostly harmless. Epigallocatechin gallate (EGCg), a type of catechin, is a well-known natural antiviral agent that can inhibit various viruses. However, EGCg easily oxidizes and loses its physiological activity. Although this problem can be overcome by combining EGCg with cyclodextrin (CD-EGCg), which makes it stable in water at high concentrations, the antiviral effect of this compound remains unclear. Here, we show that in Madin&ndash;Darby canine kidney (MDCK) and MRC-5 cells, CD-EGCg is cytotoxic for 50% of cells at 85.61 and 65.34 ppm, respectively. Furthermore, CD-EGCg mainly shows its antiviral effect during the adsorption step for all four influenza virus strains (median effect concentration (EC50) was 0.93 to 2.78 ppm). Its antiviral effect post-adsorption is less intense, and no inhibitory effect is observed on influenza viruses pre-adsorption. Moreover, human coronavirus 229E (HCoV-229E) was inhibited at the adsorption step in short contact (EC50 = 2.5 ppm) and long contact conditions (EC50 = 0.5 ppm) by mixing CD-EGCg with HCoV-229E. These results suggest that CD-EGCg effectively inhibits various viruses that require an adsorption step, and is an effective tool for preventing infection

Selected Chapters on Baseball History in the World and the Czech Republic

Vybrané kapitoly z historie baseballu ve světě a ČR Selected chapters from baseball history in the world and the Czech Republic Cíl práce: Zpracovat prapočátky baseballu a vyřešit otázku původu baseballu, zmínit nejvýznamnější momenty ve světové historii baseballu, analyzovat historii a současnou situaci baseballu v ČR a navrhnout možnosti zlepšení situace v Česku. Metoda: Pro zpracování základních informací z historie baseballu byla v největším rozsahu použita metoda přímá, induktivní a deduktivní. Dále pak bylo použito metody diachronní progresivní, kvantitativní a komparativní. Výsledky: Mohou pomoci seznámit se s baseballovým odvětvím, blíže pak s jeho celosvětovým vývojem. Klíčová slova: Baseball, Major league baseball, American league, Nationalleague, liga, tým, hráč, USA. V Praze, dne 31. srpna 2006. 1KinantropologieFaculty of Physical Education and SportFakulta tělesné výchovy a sport

Construction of perfectly continuous records of physical properties for dark-light sediment sequences collected from the Japan Sea during Integrated Ocean Drilling Program Expedition 346 and their potential utilities as paleoceanographic studies

Abstract Establishment of sedimentary sequence is essential for the interpretation of the sedimentary records. Integrated Ocean Drilling Program (IODP) Expedition (Exp.) 346 drilled high-quality sediment archives with more than three holes each at nine sites that enable us to establish continuous sedimentary sequences through splicing technique. After extensive efforts to replace the disturbed, missed, or duplicated intervals found in spliced sediment sequences constructed onboard during IODP Exp. 346 to the corresponding undisturbed intervals, nearly perfectly continuous sediment columns and physical property records for the Pleistocene intervals of Sites U1422-U1427 and U1430 collected from the Japan Sea have been established. Same kind of efforts to correct the shipboard splices were also achieved for Plio-Miocene intervals at Sites U1425 and U1430. The continuous records established for these sites will allow a much more detailed understanding of the long-term variability in East Asian paleoclimate and North Pacific oceanography

The Potential Impact of Age on Gut Microbiota in Patients with Major Depressive Disorder: A Secondary Analysis of the Prospective Observational Study

We aimed to investigate the impact of aging on the relationship among the composition of gut microbiota, gastrointestinal (GI) symptoms, and the course of treatment for major depressive disorder (MDD) by analyzing the datasets from our previous study. Patients with MDD were recruited, and their stools were collected at three time points (baseline, midterm, and endpoint) following the usual antidepressant treatment. Gut microbiota were analyzed using 16S rRNA gene sequencing. Patients were categorized into two groups based on their age: the late-life group over 60 years and the middle-aged group under 60 years. GI symptoms were assessed with scores of item 11 of the Hamilton Anxiety Rating Scale. One hundred and ninety samples were collected from 32 patients with MDD. Several gut microbes had higher relative abundances in the late-life group than in the middle-aged group. In addition, the late-life group showed significantly higher diversity in the Chao1 index at baseline compared with the middle-aged group. We further found possible microbial taxa related to GI symptoms in patients with late-life depression. The abundance of several bacterial taxa may contribute to GI symptoms in the late-life depression, and our findings suggest that the therapeutic targets for the application of gut microbiota may differ depending on the age group of patients with depression

Additional file 17: of Construction of perfectly continuous records of physical properties for dark-light sediment sequences collected from the Japan Sea during Integrated Ocean Drilling Program Expedition 346 and their potential utilities as paleoceanographic studies

Table S8. Calculation worksheet for U1422 revised depth scale (CCSF-D_Patched_rev20150416). (XLSX 98 kb

Additional file 4: of Construction of perfectly continuous records of physical properties for dark-light sediment sequences collected from the Japan Sea during Integrated Ocean Drilling Program Expedition 346 and their potential utilities as paleoceanographic studies

Figure S4. Graphic representations of inter-hole correlations for IODP Exp. 346 Sites U1425. Originally spliced intervals are indicated by blue lines next to core photographs. Disturbed or missing intervals found during visual inspection are indicated by blue broken lines. These disturbed or missing intervals were amended by the corresponding undisturbed “patch” intervals indicated by pink lines. (PDF 8638 kb

Multicultural upbringing and education of Czech and Vietnamese pupils

Tato práce si klade za cíl zmapovat stav multikulturní výchovy a vzdělávání na vybraných pražských školách. K tomuto zjišťování byla použita metoda dotazníkového šetření. Z výzkumu vyplynulo, že zkoumané školy mají o problematice multikulturní výchovy a vzdělávání poměrně jasnou představu, problém však nastává při financování jednotlivých aktivit. Tato práce má zároveň sloužit jako přehledný zdroj informací pro české pedagogy, kde naleznou podrobné informace o Vietnamu, jeho historii, kultuře a tradicích. Dále nabízí možnost seznámit se s vietnamským jazykem, výslovností a vietnamskými jmény. V závěru teoretické části jsou uvedeny vybrané odkazy na webové stránky, které se zabývají právě multikulturalitou. Jak multikulturní výchovu a vzdělávání převést do praktické roviny naznačuje zpracované strukturované drama dle námětu vietnamských pohádek. V závěru práce jsou nastíněny další možnosti využití přítomnosti žáků jiné kultury ve třídě. Powered by TCPDF (www.tcpdf.org)The scope of this document is to find out an actual situation and presence of the multicultural education at selected Prague's elementary schools. A methodology of Questionnaire's research has been used for acquiring of the data. The research's result stated out clear vision of a need multicultural education but also were discovered economical problems during financing particulars activities. The document might to help to the Czech teachers as the overview and data's resource of the information of about Vietnam, Vietnamese culture, history and traditions. The document is divided to four parts (introduction, theoretical and practical part, conclusion); on the end of the theoretical part is a list of the web pages referring about multiculturahty. One chapter is dedicated to Vietnamese language, pronunciation and names. A possible way how to transfer multicultural education from the theoretical level to practice is presented by structured drama based on Vietnamese tale stories. On the end are described another options to take in classroom's presence of pupils from different cultures. Powered by TCPDF (www.tcpdf.org)Katedra primární pedagogikyFaculty of EducationPedagogická fakult