Creation of Digital Elevated Model using lunar images of Chandrayan – 1

The present work discusses the technique and methodology of analysing and Terrain Mapping Camera (TMC) Images acquired during India’s first  Moon mission, Chandrayaan  – 1, launched on October, 2008  for generating Digital Elevated Model (DEM). The Terrain Mapping Camera (TMC) on India’s first satellite for lunar exploration, Chandrayaan-1, is intended for systematic topographic mapping of the entire lunar surface, including the far side and the polar regions. A high resolution imagery of the entire Moon will help detailed study of specific lunar regions of scientific interests and further our understanding of lunar evolution. The swath of the instrument is 20 km. The digital elevation model (DEM) is a computer representation of the moon’s surface. DEMs can be generated by traditional photogrammetry based on aerial photos if they are available and they are created very often more economically by the means of space images. A Digital Terrain Model (DEM) is a continuous representation of a ground surface landform that is commonly used to produce topographic maps. DEMs are created by integrating data obtained from a wide range of techniques including remote sensing and land surveying.DEM's are sampled arrays of elevation values representing ground positions at regularly spaced intervals. Digital Elevation Model (DEM) is the terminology adopted by the USGS to describe terrain elevation data sets in a digital raster form.  The normal orientation of data is by columns and rows. In this project work a DEM is created for each of the lunar images retrieved from the space craft using Triangulated Irregular Network (TIN)Key Words : Chandrayaan-1, DEM, Swath, TMC, TINDOI:http://dx.doi.org/10.11591/ijece.v1i2.8

MBER Space Time Equalization assisted Multiuser Detection

A novel minimum bit-error rate (MBER) space–time-equalization (STE)-based multiuser detector (MUD) is proposed for multiple-receive-antenna-assisted space-division multiple-access systems. It is shown that the MBER-STE-aided MUD significantly outperforms the standard minimum mean-square error design in terms of the achievable bit-error rate (BER). Adaptive implementations of the MBER STE are considered, and both the block-databased and sample-by-sample adaptive MBER algorithms are proposed. The latter, referred to as the least BER (LBER) algorithm, is compared with the most popular adaptive algorithm, known as the least mean square (LMS) algorithm. It is shown that in case of binary phase-shift keying, the computational complexity of the LBER-STE is about half of that required by the classic LMS-STE. Our simulation results demonstrate that the MBER ST-DFE assisted MUD is more robust to channel estimation errors as well as to potential error propagation imposed by decision feedback errors, compared to the MMSE ST-DFE assisted MUD

A VLSI Approach for Cache Compression in Microprocessor

Speed is one of the important issues that generally customers consider for selecting any electronic component in the market. Speed of a microprocessor based system mainly depends on the speed of the microprocessor which in turn depends on the memory access time. Accessing on chip memory takes more time than accessing off-chip memory. Because of these, designers of memory system may find cache compression as an advantageous method to increase speed of a microprocessor based system, as it increases cache capacity and off-chip bandwidth. The However, most past work, and all work on cache compression, has made unsubstantiated assumptions about the performance, power consumption, and area overheads of the proposed compression algorithms and hardware. It is not possible to determine whether compression at levels of the memory hierarchy closest to the processor is beneficial without understanding its costs. Proposed hardware compression algorithms fall into the dictionary-based category, which depend on building a dictionary and using its entries to encode repeated data values. Proposed algorithm has number of novel features like including combining pairs of compressed lines into one cache line and allowing parallel compression of multiple words while using a single dictionary and without degradation in compression ratio

Multiplier Based On Add And Shift Method By Passing Zero

In this paper, a low-power structure for shift-and-add multipliers is proposed. The architec-ture considerably lowers the switching activity of conventional multipliers. The modification to the multiplier which multiplies A by B include the removal of the shifting register, direct feeding of A to the adder, bypassing the adder whenever possible, using a ring counter instead of a binary counter and removal of the partial product shift. The architecture makes use of a low-power ring counter proposed in this work . The proposed multiplier can be used for low-power applications where the speed is not a primary design parameter

Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming

Coinfections with pathogenic microbes continually confront cervical mucosa, yet their implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical epithelium has been a bottleneck to study coinfections. Using patient-derived ectocervical organoids, we systematically modeled individual and coinfection dynamics of Human papillomavirus (HPV)16 E6E7 and Chlamydia, associated with carcinogenesis. The ectocervical stem cells were genetically manipulated to introduce E6E7 oncogenes to mimic HPV16 integration. Organoids from these stem cells develop the characteristics of precancerous lesions while retaining the self-renewal capacity and organize into mature stratified epithelium similar to healthy organoids. HPV16 E6E7 interferes with Chlamydia development and induces persistence. Unique transcriptional and post-translational responses induced by Chlamydia and HPV lead to distinct reprogramming of host cell processes. Strikingly, Chlamydia impedes HPV-induced mechanisms that maintain cellular and genome integrity, including mismatch repair in the stem cells. Together, our study employing organoids demonstrates the hazard of multiple infections and the unique cellular microenvironment they create, potentially contributing to neoplastic progression

Anti-cancer effects and mechanism of actions of aspirin analogues in the treatment of glioma cancer

INTRODUCTION: In the past 25 years only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of cancer with multiple mechanisms of action proposed including COX 2 inhibition, down regulation of EGFR expression, and NF-κB signaling affecting Bcl-2 expression. However, with serious side effects such as stroke and gastrointestinal bleeding, aspirin analogues with improved potency and side effect profiles are being developed. METHOD: Effects on cell viability following 24 hr incubation of four aspirin derivatives (PN508, 517, 526 and 529) were compared to cisplatin, aspirin and di-aspirin in four glioma cell lines (U87 MG, SVG P12, GOS – 3, and 1321N1), using the PrestoBlue assay, establishing IC50 and examining the time course of drug effects. RESULTS: All compounds were found to decrease cell viability in a concentration and time dependant manner. Significantly, the analogue PN517 (IC50 2mM) showed approximately a twofold increase in potency when compared to aspirin (3.7mM) and cisplatin (4.3mM) in U87 cells, with similar increased potency in SVG P12 cells. Other analogues demonstrated similar potency to aspirin and cisplatin. CONCLUSION: These results support the further development and characterization of novel NSAID derivatives for the treatment of glioma

Ubiquitous robust communications for emergency response using multi-operator heterogeneous networks

A number of disasters in various places of the planet have caused an extensive loss of lives, severe damages to properties and the environment, as well as a tremendous shock to the survivors. For relief and mitigation operations, emergency responders are immediately dispatched to the disaster areas. Ubiquitous and robust communications during the emergency response operations are of paramount importance. Nevertheless, various reports have highlighted that after many devastating events, the current technologies used, failed to support the mission critical communications, resulting in further loss of lives. Inefficiencies of the current communications used for emergency response include lack of technology inter-operability between different jurisdictions, and high vulnerability due to their centralized infrastructure. In this article, we propose a flexible network architecture that provides a common networking platform for heterogeneous multi-operator networks, for interoperation in case of emergencies. A wireless mesh network is the main part of the proposed architecture and this provides a back-up network in case of emergencies. We first describe the shortcomings and limitations of the current technologies, and then we address issues related to the applications and functionalities a future emergency response network should support. Furthermore, we describe the necessary requirements for a flexible, secure, robust, and QoS-aware emergency response multi-operator architecture, and then we suggest several schemes that can be adopted by our proposed architecture to meet those requirements. In addition, we suggest several methods for the re-tasking of communication means owned by independent individuals to provide support during emergencies. In order to investigate the feasibility of multimedia transmission over a wireless mesh network, we measured the performance of a video streaming application in a real wireless metropolitan multi-radio mesh network, showing that the mesh network can meet the requirements for high quality video transmissions

Short- and long-term cause-specific survival of patients with inflammatory breast cancer

BACKGROUND: Inflammatory breast cancer (IBC) had been perceived to have a poor prognosis. Oncologists were not enthusiastic in the past to give aggressive treatment. Single institution studies tend to have small patient numbers and limited years of follow-up. Most studies do not report 10-, 15- or 20-year results. METHODS: Data was obtained from the population-based database of the Surveillance, Epidemiology, and End Results program of the National Cancer Institute from 1975–1995 using SEER*Stat5.0 software. This period of 21 years was divided into 7 periods of 3 years each. The years were chosen so that there was adequate follow-up information to 2000. ICD-O-2 histology 8530/3 was used to define IBC. The lognormal model was used for statistical analysis. RESULTS: A total of 1684 patients were analyzed, of which 84% were white, 11% were African Americans, and 5% belonged to other races. Age distribution was < 30 years in 1%, 30–40 in 11%, 40–50 in 22%, 50–60 in 24%, 60–70 in 21%, and > 70 in 21%. The lognormal model was validated for 1975–77 and for 1978–80, since the 10-, 15- and 20-year cause-specific survival (CSS) rates, could be calculated using the Kaplan-Meier method with data available in 2000. The data were then used to estimate the 10-, 15- and 20-year CSS rates for the more recent years, and to study the trend of improvement in survival. There were increasing incidences of IBC: 134 patients in the 1975–77 period to 416 patients in the 1993–95 period. The corresponding 20-year CSS increased from 9% to 20% respectively with standard errors of less than 4%. CONCLUSION: The improvement of survival during the study period may be due to introduction of more aggressive treatments. However, there seem to be no further increase of long-term CSS, which should encourage oncologists to find even more effective treatments. Because of small numbers of patients, randomized studies will be difficult to conduct. The SEER population-based database will yield the best possible estimate of the trend in improvement of survival for patients with IBC