6 research outputs found
Psoriasis lingual : aspects cliniques et associations épidémiologiques chez 313 enfants, avec revue systématique de la littérature
IF 1,051 (2018)International audienceBackground. - Little information is available on the prevalence and clinical aspects of tongue involvement in children with psoriasis. The aim was to evaluate the prevalence, clinical aspects and risk factors concerning tongue involvement in children with psoriasis.Patients and methods. - This study was carried out in two stages. We performed a multicentre, cross-sectional study in 23 French dermatology centers. All children seen for psoriasis during the one-year study were systematically included. The clinical features of the tongue and of psoriasis were recorded. Association with clinical aspects of psoriasis and comorbidities was evaluated. We then carried out a literature review to evaluate the prevalence of tongue involvement in children with psoriasis and its positive predictive value for psoriasis. A search was conducted in the PUBMED database using the following keywords: "child'' and "psoriasis'' and ("tongue'' or "glossitis'' or "migratory glossitis'' or "benign migratory glossitis'' or "geographic tongue'' or "fissured tongue'').Results. - 7.7% of the 313 children with psoriasis had tongue involvement. The clinical aspects were geographic tongue (4.2%), fissured tongue (2.8%) and both (0.64%). There was no association between tongue involvement and the clinical characteristics of the children. Two hundred and ninety-five articles were referenced and 3 were analysed. Psoriasis is very rare in cases of tongue abnormalities.Conclusion. - The prevalence of tongue involvement was 7.7% in children with psoriasis. No clinical or epidemiological association was shown. Tongue involvement does not modify the management of psoriasis. In the literature review it was not possible to evaluate either the prevalence of tongue involvement in psoriasis or the positive predictive value thereof.IntroductionIl y a peu dâinformations dans la littĂ©rature sur les atteintes de la langue au cours du psoriasis de lâenfant. Lâobjectif Ă©tait dâĂ©valuer la frĂ©quence, les aspects cliniques et les facteurs de risque dâatteinte linguale chez les enfants psoriasiques.Patients et mĂ©thodesCe travail a Ă©tĂ© effectuĂ© en deux Ă©tapes : (1) une Ă©tude transversale a Ă©tĂ© menĂ©e dans 23 centres dermatologiques français, notant les aspects cliniques de la langue et du psoriasis chez les enfants atteints de psoriasis, ainsi que les associations et les comorbiditĂ©s ; (2) une revue systĂ©matique de la littĂ©rature a ensuite Ă©tĂ© effectuĂ©e afin dâĂ©valuer la prĂ©valence lâatteinte linguale chez lâenfant et sa valeur prĂ©dictive du psoriasis. Une recherche a Ă©tĂ© rĂ©alisĂ©e en interrogeant la base de donnĂ©es PUBMED. Les mots clĂ©s saisis Ă©taient : « child » et « psoriasis » et (« tongue » ou « glossitis » ou « migratory glossitis » ou « benign migratory glossitis » ou « geographic tongue » ou « fissured tongue »).RĂ©sultats(1) Parmi 313 enfants atteints de psoriasis 7,7 % prĂ©sentaient une atteinte linguale sous forme de langue gĂ©ographique (4,2 %), langue fissurĂ©e (2,8 %) ou les deux (0,6 %). Lâatteinte linguale nâĂ©tait associĂ©e Ă aucune particularitĂ© dĂ©mographique ou clinique, ni aucune comorbiditĂ©. (2) Parmi 295 articles rĂ©fĂ©rencĂ©s, 3 ont finalement Ă©tĂ© retenus. Le psoriasis reste trĂšs rare en cas dâanomalie linguale.ConclusionLa prĂ©valence de lâatteinte linguale chez les enfants psoriasiques Ă©tait de 7,7 %. Aucune association clinique ou Ă©pidĂ©miologique nâa Ă©tĂ© montrĂ©e. Lâatteinte linguale ne modifie pas la prise en charge du psoriasis. La revue systĂ©matique de la littĂ©rature ne permettait pas dâĂ©valuer une prĂ©valence de lâatteinte linguale dans le psoriasis ni la valeur prĂ©dictive positive de cette atteinte
Reasons for discontinuation of dupilumab in adult atopic dermatitis in clinical practice
International audienc
Effectiveness and safety of anti-interleukin-17 therapies in elderly patients with psoriasis
Anti-interleukin-17 agents have recently been develo-ped for the treatment of psoriasis. This study evaluated the tolerance and effectiveness of anti-interleukin-17 agents for psoriasis in elderly patients in daily practi-ce. A multicentre, retrospective study was performed, involving psoriatic patients aged â„65 years who had received an anti-interleukin-17 agent, including se-cukinumab, ixekizumab or brodalumab. A total of 114 patients were included: 72 received secukinumab, 35 ixekizumab, and 7 brodalumab. Treatment was stop-ped in 32 patients (28.9%), because of relapses in 14 patients (41.2%), primary failures in 11 patients (32.4%), or adverse events in 7 patients (20.6%). The 3 most frequently reported adverse events were injec-tion site reactions (n = 4), oral candidiasis (n = 3), and influenza-like illness (n = 3). Regarding effectiveness, 80 patients (70%) reached a Physician Global Assessment score of 0/1, 6 months after treatment initiation. In conclusion, anti-interleukin-17 therapy appears to be an effective and safe therapeutic option for psoriasis treatment in patients aged â„ 65 years
Real-World Effectiveness and Safety of Apremilast in Older Patients with Psoriasis
Introduction: Apremilast is a drug recently developed for psoriasis. Few data are available on its use in the elderly. We evaluated the tolerance and effectiveness of apremilast used in daily practice for psoriasis treatment in older patients. Methods: We performed a multicenter, retrospective study involving patients aged â„ 65 years who had received apremilast as a psoriasis treatment. Demographic data and details regarding psoriasis and adverse events (AEs) were collected from patient medical records. Results: 135 patients were included (mean age: 73.5 years). Treatment was stopped in 74 patients (54.8%) for AEs (n = 43, 56.6%), primary failures (n = 18, 23.4%), and relapses (n = 7, 9.2%). When patients were stratified by age at treatment initiation, the main cause of discontinuation in patients â„ 75 years was AEs, whereas in patients aged 65â74 years it was primary failures (28.3%). Sixty-one patients reported AEs, mainly digestive (n = 49). Regarding effectiveness, 45.2% of patients reached PGA 0/1 between 3 and 6 months after treatment initiation. One-year apremilast continuation rates were better in the 65â74 and 75â84 years subgroups than in the > 85 years subgroup (p = 0.01). Conclusion: Apremilast seems to be an effective and safe therapeutic option for psoriasis in the elderly. The main AEs reported by patients did not seem to differ from those reported previously in younger populations. However, AEs were more frequent in patients > 75 years old leading to more frequent discontinuation of apremilast compared with younger patients, suggesting a higher level of vigilance is needed in the elderly