Intravitreal bevacizumab for the treatment of macular oedema secondary to branch retinal vein occlusion

Purpose: To evaluate the effect of intravitreal bevacizumab (Avastin) injections on visual acuity (VA) and foveal retinal thickness in patients with macular oedema secondary to branch retinal vein occlusion.Methods: A prospective, non-comparative, consecutive, interventional case series of 34 patients. Patients received repeated intravitreal injections of 1.25 mg bevacizumab. Main outcome measures were VA (Snellen charts and ETDRS) and retinal thickness (optical coherence tomography measurements) in a follow-up period of 6 months.Results: Patients presented at a mean age of 69 years (range 44--86). Mean duration of symptoms was 40 weeks (range 1--300). Mean (SD) VA at baseline was 0.79 (0.39) logMAR, improving to 0.51 (0.34) logMAR at 6 months (p = 0.009). Mean number of letters on the ETDRS chart at baseline was 45.3 (19.0), improving to 60.6 (19.9) at 6 months (p = 0.003). Mean (SD) retinal thickness at baseline was 474 (120) \textgreekmm, declining to 316 (41) \textgreekmm at 6 months.Conclusion: Intravitreal injection of 1.25 mg bevacizumb appears to be an effective treatment option for branch retinal vein occlusion

Facilitating low-carbon living? A comparison of intervention measures in different community-based initiatives

The challenge of facilitating a shift towards sustainable housing, food and mobility has been taken up by diverse community-based initiatives ranging from ‘top-down’ approaches in low-carbon municipalities to ‘bottom-up’ approaches in intentional communities. This paper compares intervention measures of these two types, focusing on their potential of re-configuring daily housing, food and mobility practices. Taking up critics on dominant intervention framings of diffusing low-carbon technical innovations and changing individual behaviour, we draw on social practice theory for the empirical analysis of four case studies. Framing interventions in relation to re-configuring daily practices, the paper reveals differences and weaknesses of current low-carbon measures of community-based initiatives in Germany and Austria. Low-carbon municipalities mainly focus on introducing technologies and offering additional infrastructure and information to promote low-carbon practices. They avoid interfering into residents’ daily lives and do not restrict carbon-intensive practices. In contrast, intentional communities base their interventions on the collective creation of shared visions, decisions and rules and thus provide social and material structures, which foster everyday low-carbon practices and discourage carbon-intensive ones. The paper discusses the relevance of organisational and governance structures for implementing different types of low-carbon measures and points to opportunities for broadening current policy strategies

Investigating patterns of local climate governance: How low-carbon municipalities and intentional communities intervene in social practices

The local level has gained prominence in climate policy and governance in recent years as it is increasingly perceived as a privileged arena for policy experimentation and social and institutional innovation. However, the success of local climate governance in industrialized countries has been limited. One reason may be that local communities focus too much on strategies of technology-oriented ecological modernization and individual behavior change and too little on strategies that target unsustainable social practices and their embeddedness in complex socioeconomic patterns. In this paper we assess and compare the strategies of "low-carbon municipalities" (top-down initiatives) and those of "intentional communities" (bottom-up initiatives). We were interested to determine to what extent and in which ways each community type intervenes in social practices to curb carbon emissions and to explore the scope for further and deeper interventions on the local level. Using an analytical framework based on social practice theory we identify characteristic patterns of intervention for each community type. We find that low-carbon municipalities face difficulties in transforming carbon-intensive social practices. While offering some additional low-carbon choices, their ability to reduce carbon-intensive practices is very limited. Their focus on efficiency and individual choice shows little transformative potential. Intentional communities, by contrast, have more institutional and organizational options to intervene in the web of social practices. Finally, we explore to what extent low-carbon municipalities can learn from intentional communities and propose strategies of hybridization for policy innovation to combine the strengths of both models

Investigating patterns of local climate governance: how low-carbon municipalities and intentional communities intervene into social practices

The local level has gained prominence in climate policy and governance in recent years as it is increasingly perceived as privileged arena for policy experimentation and social and institutional innovation. Yet, the success of local climate governance in industrialised countries has been limited so far. One reason may be that local communities focus too much on strategies of technology-oriented ecological modernisation (EM) and individual behaviour change and too little on strategies that target unsustainable social practices and their embeddedness in complex patterns of practices. In this paper we assess and compare the strategies of ‘low-carbon municipalities’ (top-down initiatives) and those of ‘intentional communities’ (bottom-up initiatives). We are interested to find out to what extent and in which ways each community type intervenes in social practices to curb carbon emissions and to explore the scope for further and deeper interventions on the local level. Employing an analytical framework based on social practice theory we identify characteristic patterns of intervention for each community type. We find that low-carbon municipalities face tenacious difficulties in transforming carbon-intensive social practices. While offering some additional low-carbon choices, their ability to reduce carbon-intensive practices is very limited. Their focus on efficiency and individual choice shows little transformative potential. Intentional communities, by contrast, have more institutional and organisational options to intervene into the web of social practices. Finally, we explore to what extent low-carbon municipalities can learn from intentional communities and propose strategies of hybridisation for policy innovation to combine the strengths of both models

Динамика частотного реверса асинхронного двигателя

Для исследования реверсирования асинхронного двигателя сравниваются два способа частотной и противовключением. Анализируются различные законы изменения частоты статора и их влияние на быстродействие, пульсации момента, плавность

Design, Manufacturing, and Characterization of Thin, Core-Free, Rolled Dielectric Elastomer Actuators

In this work, we develop a coreless rolled dielectric elastomer actuator (CORDEA) to be used as artificial muscles in soft robotic structures. The new CORDEA concept is based on a 50 µm silicone film with screen-printed electrodes made of carbon black suspended in polydimethylsiloxane. Two printed silicone films are stacked together and then tightly rolled in a spiral-like structure. Readily available off-the-shelf components are used to implement both electrical and mechanical contacts. A novel manufacturing process is developed to enable the production of rolled actuators without a hollow core, with a focus on simplicity and reliability. In this way, actuator systems with high energy density can be effectively achieved. After presenting the design, an experimental evaluation of the CORDEA electromechanical behavior is performed. Finally, actuator experiments in which the CORDEA is pre-loaded with a mass load and subsequently subject to cycling voltage are illustrated, and the resulting performance is discussed

Interfacial Water Structure as a Descriptor for Its Electro-Reduction on Ni(OH)2-Modified Cu(111)

The hydrogen evolution reaction (HER) has been crucial for the development of fundamental knowledge on electrocatalysis and electrochemistry, in general. In alkaline media, many key questions concerning pH-dependent structure–activity relations and the underlying activity descriptors remain unclear. While the presence of Ni(OH)2 deposited on Pt(111) has been shown to highly improve the rate of the HER through the electrode’s bifunctionality, no studies exist on how low coverages of Ni(OH)2 influence the electrocatalytic behavior of Cu surfaces, which is a low-cost alternative to Pt. Here, we demonstrate that Cu(111) modified with 0.1 and 0.2 monolayers (ML) of Ni(OH)2 exhibits an unusual non-linear activity trend with increasing coverage. By combining in situ structural investigations with studies on the interfacial water orientation using electrochemical scanning tunneling microscopy and laser-induced temperature jump experiments, we find a correlation between a particular threshold of surface roughness and the decrease in the ordering of the water network at the interface. The highly disordered water ad-layer close to the onset of the HER, which is only present for 0.2 ML of Ni(OH)2, facilitates the reorganization of the interfacial water molecules to accommodate for charge transfer, thus enhancing the rate of the reaction. These findings strongly suggest a general validity of the interfacial water reorganization as an activity descriptor for the HER in alkaline media.A.A. is a recipient of a doctorate (DOC) Fellowship of the Austrian Academy of Sciences at the Institute of Physical Chemistry. C.G. thanks the Austrian Research Promotion Agency (FFG) for funding via the project number 870523. J.K.-L. acknowledges funding by the Austrian Science Fund (FWF) via grant I-4114-N37. J.M.F. and V.C. acknowledge financial support from Ministerio de Ciencia e Innovación (project PID2019-105653GB-100) and Generalitat Valenciana (project PROMETEO/2020/063)

Expression pattern of a nuclear encoded mitochondrial arginine-ornithine translocator gene from Arabidopsis

BACKGROUND: Arginine and citrulline serve as nitrogen storage forms, but are also involved in biosynthetic and catabolic pathways. Metabolism of arginine, citrulline and ornithine is distributed between mitochondria and cytosol. For the shuttle of intermediates between cytosol and mitochondria transporters present on the inner mitochondrial membrane are required. Yeast contains a mitochondrial translocator for ornithine and arginine, Ort1p/Arg11p. Ort1p/Arg11p is a member of the mitochondrial carrier family (MCF) essential for ornithine export from mitochondria. The yeast arg11 mutant, which is deficient in Ort1p/Arg11p grows poorly on media lacking arginine. RESULTS: High-level expression of a nuclear encoded Arabidopsis thaliana homolog (AtmBAC2) of Ort1p/Arg11p was able to suppress the growth deficiency of arg11. RT-PCR analysis demonstrated expression of AtmBAC2 in all tissues with highest levels in flowers. Promoter-GUS fusions showed preferential expression in flowers, i.e. pollen, in the vasculature of siliques and in aborted seeds. Variable expression was observed in leaf vasculature. Induction of the promoter was not observed during the first two weeks in seedlings grown on media containing NH(4)NO(3), arginine or ornithine as sole nitrogen sources. CONCLUSION: AtmBAC2 was isolated as a mitochondrial transporter for arginine in Arabidopsis. The absence of expression in developing seeds and in cotyledons of seedlings indicates that other transporters are responsible for storage and mobilization of arginine in seeds

Simulations of spectral lines from an eccentric precessing accretion disc

Two dimensional SPH simulations of a precessing accretion disc in a q=0.1 binary system (such as XTE J1118+480) reveal complex and continuously varying shape, kinematics, and dissipation. The stream-disc impact region and disc spiral density waves are prominent sources of energy dissipation.The dissipated energy is modulated on the period P_{sh} = ({P_{orb}}^{-1}-{P_{prec}}^{-1}^{-1} with which the orientation of the disc relative to the mass donor repeats. This superhump modulation in dissipation energy has a variation in amplitude of ~10% relative to the total dissipation energy and evolves, repeating exactly only after a full disc precession cycle. A sharp component in the light curve is associated with centrifugally expelled material falling back and impacting the disc. Synthetic trailed spectrograms reveal two distinct "S-wave" features, produced respectively by the stream gas and the disc gas at the stream-disc impact shock. These S-waves are non-sinusoidal, and evolve with disc precession phase. We identify the spiral density wave emission in the trailed spectrogram. Instantaneous Doppler maps show how the stream impact moves in velocity space during an orbit. In our maximum entropy Doppler tomogram the stream impact region emission is distorted, and the spiral density wave emission is uppressed. A significant radial velocity modulation of the whole line profile occurs on the disc precession period. We compare our SPH simulation with a simple 3D model: the former is appropriate for comparison with emission lines while the latter is preferable for skewed absorption lines from precessing discs.Comment: See http://physics.open.ac.uk/FHMR/ for associated movie (avi) files. The full paper is in MNRAS press. Limited disk space limit of 650k, hence low resolution figure file

Resonances in a two-dimensional electron waveguide with a single delta-function scatterer

We study the conductance properties of a straight two-dimensional electron waveguide with an s-like scatterer modeled by a single delta-function potential with a finite number of modes. Even such a simple system exhibits interesting resonance phenomena. These resonances are explained in terms of quasi-bound states both by using a direct solution of the Schroedinger equation and by studying the Green's function of the system. Using the Green's function we calculate the survival probability as well as the power absorption and show the influence of the quasi-bound states on these two quantities.Comment: 5 pages, 6 figures, to be published in Physical Review