Russian Language at Columbus International High School

IMPACT. 1: 22 students enrolled in the courses in the 2012-2013 academic year. -- 2. 81% of the students at the high school receive free/reduced lunch and 85% are from a minority background. -- 3. Russian is the 3rd language that these students are learning.OSU PARTNERS: Center for Slavic and East European Studies; Department of Slavic and East European Languages and CulturesCOMMUNITY PARTNERS: Columbus International High SchoolPRIMARY CONTACT: Eileen Kunkler ([email protected])The Center for Slavic and East European Studies co-sponsors two Russian language courses at Columbus International High School. This is part of its mission as a federal Department of Education National Resource Center (Title VI) to expand the knowledge of Eastern Europe and Eurasia in Ohio and the Midwest, and in particular for traditionally underrepresented groups. The high school focuses on teaching students languages and an international curriculum, giving them global competencies

HIGH-FREQUENCY TRANSACTION DATA: A COMPARISON BETWEEN TWO ASYMMETRIC MODELS

This paper compares two asymmetric models for high-frequency transaction data in financial markets, namely, the three-state Asymmetric Autoregressive Conditional Duration (AACD) model and the Activity Direction Size (ADS) model. It is shown that the two asymmetric models measure different aspects of the same underlying asymmetric nature of high-frequency transaction data. It is also shown that by extending the AACD model to include two size variables and adjusting for partial durations, each model’s parameter estimates can be used to estimate the other model’s parameters exactly. Thus, the two asymmetric models are equivalent, and measure the durations and price changes jointly.   Keywords: High-frequency transaction data   JEL: G1

The impact of maternal prenatal methamphetamine exposure on child behavioural development: A systematic review

Methamphetamine (MA) use during pregnancy is associated with a range of adverse neurodevelopmental implications for a developing fetus. This systematic review examines studies which report the effects of prenatal MA exposure in utero on infant and child behavioural development. A systematic search of PSYCINFO, Scopus, PubMed and ERIC databases was conducted and 839 records were identified. A total of 15 articles met inclusion criteria, examining behavioural outcomes in children from birth to nine years of age. This review found consistent reports of behavioural dysregulation in neonates and children prenatally exposed to MA. Furthermore, the results indicate that children with prenatal MA exposure display more pronounced behavioural difficulties as they age. However, the small number of longitudinal studies and the narrow breadth of populations sampled limits the interpretation and generalisability of these findings. Future research should consider these limitations and conduct longitudinal studies, with a broader range of population samples, to determine the temporal association between prenatal MA exposure and behavioural outcomes. These findings have implications for early identification and prevention of later behavioural dysfunction as a result of prenatal MA exposure. It is crucial to prevent maternal MA use during pregnancy and to provide postnatal service care for parents of children with prenatal MA exposure; so they have to ability to support and promote a more adaptive developmental trajectory for their child. Keywords: methamphetamine, prenatal drug exposure, fetal behaviour, child behaviou

Oncolytic Viroradiotherapy for Neuroblastoma

College of Education and Human Ecology Undergraduate Research ScholarshipNeuroblastoma is the most common extra-cranial solid tumor in childhood and the leading cause of childhood cancer mortality. MIBG (meta-iodobenzylguanidine), an analogue of noradrenaline, is a form of targeted radiation therapy for high-risk neuroblastoma when bound to 131Iodine. MIBG enters cells through the norepinephrine transporter (NET), a protein expressed on the surface of neuroendocrine cells, including most neuroblastoma cells. 131I-MIBG then radiates the cells it enters and induces cytotoxicity in surrounding cells. However, 131I-MIBG is not always effective, likely in part due to low NET expression in high-risk neuroblastomas. Oncolytic virotherapy is a promising therapeutic approach currently in clinical trials. Previously, our lab has shown that preclinical models of neuroblastoma are sensitive to oncolytic herpes simplex virus (oHSV) therapy. oHSV can also be used to deliver the NET transgene to tumor cells to increase susceptibility to 131I-MIBG. In the present study, we are investigating the efficacy of HSV1716/NET in increasing NET expression and thereby increasing the efficacy of 131I-MIBG. We will also evaluate if 131I-MIBG enhances viral replication. The results to date indicate that neuroblastoma cell lines are susceptible to HSV1716/NET, and upon viral infection, there is effective transfer of the NET gene resulting in an increase in 131I-MIBG uptake.No embargoAcademic Major: Human Development and Family Scienc

The Manville Corporation Bankruptcy: An Abuse of the Judicial Process?

Federal bankruptcy law offers a refuge to the honest debtor who is unable to pay his creditor\u27s when his debts are due. Here, the twin aims of bankruptcy law, to give the debtor a fresh start and to provide roughly equal treatment for his! Creditors, are laudably accomplished. But what policies support the use of federal bankruptcy law when the debtor is in fact solvent and apparently seeks refuge only to escape liability for the products it manufactures? This comment examines the recent filing of the Manville Corporation for Chapter 11 protection under bankruptcy law with this question in mind

Nature in Jung-Stilling’s Lebensgeschichte: A Study of the Portrayal of Nature in German Peasant Literature

There is a large trend in ecocriticism that focuses on, and often criticizes, the way in which nature is portrayed in Romantic literature, with critics frequently focusing on the works of authors such as Goethe. However, the portrayal of nature in peasant literature has largely gone unnoticed. Very little is written concerning this topic. Johann Heinrich Jung-Stilling’s Lebensgeschichte, published in 1777, is among the first autobiographical accounts of a man who was able to work his way out of peasantry: first teaching as a schoolmaster, eventually studying medicine at the University of Strasbourg, and becoming a professor at the University of Marburg. It was edited and submitted for publishing by Goethe, a friend of Jung-Stilling’s. The first two books, Jugend and Jünglingsjahre, relate the story of Jung-Stilling’s family and his childhood. In this account, Jung-Stilling provides realistic, accurate, and detailed imagery of the setting in which the story takes place. Furthermore, upon closer examination of both the narrator and the characters, their relationships to nature turn out to be much more complex. Examining Jugend and Jünglingsjahre more closely reveals that Jung-Stilling has created a web of protagonists, all of which have very different interactions with and relationships to nature. This variety of perspectives reflects the different views of nature at the time, as well as the beginning of Romanticism. In this study, I will analyze the different nature perspectives and how the narrator represents them. In doing so, I hope to open the doors to further study of peasant literature - in particular, of how and whether the portrayal of nature in such literature differs from canonical Romantic authors.No embargoAcademic Major: Germa

Garden of the Forebearer

Ideas about life and death have been a major source for my work since the death of my father. His loss made me question my role in life and the role of a god-creator. I chose to make a garden to set up circumstances for the contemplation of the role of god, the creator, and the cyclical nature of life and death. There is nothing more beautiful and bittersweet than being alive and loving. In my garden, I seek to understand why I was placed in this wondrous life only to suffer the inevitability of death and pain and the loss of those that I care for. I want to understand that if god has a choice, then why did he choose to put his creations through so much. In placing them, does he do so with respect, ambiguity, or detachment and to what purpose

Algorithm and Complexity for a Network Assortativity Measure

We show that finding a graph realization with the minimum Randi\'c index for a given degree sequence is solvable in polynomial time by formulating the problem as a minimum weight perfect b-matching problem. However, the realization found via this reduction is not guaranteed to be connected. Approximating the minimum weight b-matching problem subject to a connectivity constraint is shown to be NP-Hard. For instances in which the optimal solution to the minimum Randi\'c index problem is not connected, we describe a heuristic to connect the graph using pairwise edge exchanges that preserves the degree sequence. In our computational experiments, the heuristic performs well and the Randi\'c index of the realization after our heuristic is within 3% of the unconstrained optimal value on average. Although we focus on minimizing the Randi\'c index, our results extend to maximizing the Randi\'c index as well. Applications of the Randi\'c index to synchronization of neuronal networks controlling respiration in mammals and to normalizing cortical thickness networks in diagnosing individuals with dementia are provided.Comment: Added additional section on application

Induction of chronic migraine phenotypes in a rat model after environmental irritant exposure

Air pollution is linked to increased emergency department visits for headache and migraine patients frequently cite chemicals or odors as headache triggers, but the association between air pollutants and headache is not well understood. We previously reported that chronic environmental irritant exposure sensitizes the trigeminovascular system response to nasal administration of environmental irritants. Here, we examine whether chronic environmental irritant exposure induces migraine behavioral phenotypes. Male rats were exposed to acrolein, a transient receptor potential channel ankyrin-1 (TRPA1) agonist, or room air by inhalation for 4 days before meningeal blood flow measurements, periorbital cutaneous sensory testing, or other behavioral testing. Touch-induced c-Fos expression in trigeminal nucleus caudalis was compared in animals exposed to room air or acrolein. Spontaneous behavior and olfactory discrimination was examined in open-field testing. Acrolein inhalation exposure produced long-lasting potentiation of blood flow responses to a subsequent TRPA1 agonist and sensitized cutaneous responses to mechanical stimulation. C-Fos expression in response to touch was increased in trigeminal nucleus caudalis in animals exposed to acrolein compared with room air. Spontaneous activity in an open-field and scent preference behavior was different in acrolein-exposed compared with room air-exposed animals. Sumatriptan, an acute migraine treatment blocked acute blood flow changes in response to TRPA1 or transient receptor potential vanilloid receptor-1 agonists. Pretreatment with valproic acid, a prophylactic migraine treatment, attenuated the enhanced blood flow responses observed after acrolein inhalation exposures. Environmental irritant exposure yields an animal model of chronic migraine in which to study mechanisms for enhanced headache susceptibility after chemical exposure