92 research outputs found
Permanence and extinction for a nonautonomous SEIRS epidemic model
In this paper, we study the long-time behavior of a nonautonomous SEIRS epidemic model. We obtain new sufficient conditions for the permanence (uniform persistence) and extinction of infectious population of the model. By numerical examples we show that there are cases such that our results improve the previous results obtained in [T. Zhang, Z. Teng, On a nonautonomous SEIRS model in epidemiology, Bull. Math. Bio. 69 (2007) 2537-2559]. We discuss a relation between our results and open questions proposed in the paper
Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module
Quiescent neural stem cells (NSCs) in the adult mouse brain are the source of neurogenesis that regulates innate and adaptive behaviors. Adult NSCs in the subventricular zone are derived from a subpopulation of embryonic neural stem-progenitor cells (NPCs) that is characterized by a slower cell cycle relative to the more abundant rapid cycling NPCs that build the brain. Yet, how slow cell cycle can cause the establishment of adult NSCs remains largely unknown. Here, we demonstrate that Notch and an effector Hey1 form a module that is upregulated by cell cycle arrest in slowly dividing NPCs. In contrast to the oscillatory expression of the Notch effectors Hes1 and Hes5 in fast cycling progenitors, Hey1 displays a non-oscillatory stationary expression pattern and contributes to the long-term maintenance of NSCs. These findings reveal a novel division of labor in Notch effectors where cell cycle rate biases effector selection and cell fate
Monte-Carlo Simulation for an Aerogel Cherenkov Counter
We have developed a Monte-Carlo simulation code for an aerogel \v Cerenkov
Counter which is operated under a strong magnetic field such as 1.5T. This code
consists of two parts: photon transportation inside aerogel tiles, and
one-dimensional amplification in a fine-mesh photomultiplier tube. It simulates
the output photoelectron yields as accurately as 5% with only a single free
parameter. This code is applied to simulations for a B-Factory
particle-identification system.Comment: 40 pages, latex(article), 19 figure
A Measurement of the Branching Fraction for the Inclusive B --> X(s) gamma Decays with the Belle Detector
We have measured the branching fraction of the inclusive radiative B meson
decay B --> X(s) gamma to be Br(B->X(s)gamma)=(3.36 +/- 0.53(stat) +/-
0.42(sys) +0.50-0.54(th)) x 10^{-4}.
The result is based on a sample of 6.07 x 10^6 BBbar events collected at the
Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric e^+e^-
storage ring.Comment: 14 pages, 6 Postsript figures, uses elsart.cl
Measurement of Inclusive Production of Neutral Pions from Upsilon(4S) Decays
Using the Belle detector operating at the KEKB e+e- storage ring, we have
measured the mean multiplicity and the momentum spectrum of neutral pions from
the decays of the Upsilon(4S) resonance. We measure a mean of 4.70 +/- 0.04 +/-
0.22 neutral pions per Upsilon(4S) decay.Comment: 15 pages, 4 figs. Submitted to Phys.Rev.
Measurement of the CP Violation Parameter sin(2phi_1) in B^0_d Meson Decays
We present a measurement of the Standard Model CP violation parameter
sin(2phi_1) based on a 10.5 fb^{-1} data sample collected at the Upsilon(4S)
resonance with the Belle detector at the KEKB asymmetric e+e- collider. One
neutral B meson is reconstructed in the J/psi K_S, psi(2S) K_S, chi_{c1} K_S,
eta_c K_S, J/psi K_L or J/psi pi^0 CP-eigenstate decay channel and the flavor
of the accompanying B meson is identified from its charged particle decay
products. From the asymmetry in the distribution of the time interval between
the two B-meson decay points, we determine sin(2phi_1) = 0.58 +0.32-0.34 (stat)
+0.09-0.10 (syst).Comment: LaTex, 13 pages, 3 figures, submitted to P.R.
Measurement of B0d - B0d-bar mixing rate from the time evolution of dilepton events at the Upsilon(4S)
We report a determination of the B0d - B0d-bar mixing parameter Delta-m_d
based on the time evolution of dilepton yields in Upsilon(4S) decays. The
measurement is based on a 5.9 /fb data sample collected by the Belle detector
at KEKB. The proper-time difference distributions for same-sign and
opposite-sign dilepton events are simultaneously fitted to an expression
containing Delta-m_d as a free parameter. Using both muons and electrons, we
obtain Delta-m_d = 0.463 +- 0.008(stat.) +- 0.016(sys.) ps^{-1} This is the
first determination of Delta-m_d from time evolution measurements at the
Upsilon(4S). We also place limits on possible CPT violations.Comment: 12 pages, 2 figure
Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats
<p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to elucidate the mechanisms that may underlie the sensitization of trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1-C2) neurons to heat or cold stimulation of the orofacial region following glutamate (Glu) injection.</p> <p>Results</p> <p>Glu application to the tongue or whisker pad skin caused an enhancement of head-withdrawal reflex and extracellular signal-regulated kinase (ERK) phosphorylation in Vc-C2 neurons. Head-withdrawal reflex and ERK phosphorylation were also enhanced following cold stimulation of the tongue but not whisker pad skin in Glu-injected rats, and the head-withdrawal reflex and ERK phosphorylation were enhanced following heat stimulation of the tongue or whisker pad skin. The enhanced head-withdrawal reflex and ERK phosphorylation after heat stimulation of the tongue or whisker pad skin, and those following cold stimulation of the tongue but not whisker pad skin were suppressed following ionotropic glutamate receptor antagonists administration into the tongue or whisker pad skin. Furthermore, intrathecal administration of MEK1/2 inhibitor PD98059 caused significant suppression of enhanced head-withdrawal reflex in Glu-injected rats, heat head-withdrawal reflex in the rats with Glu injection into the tongue or whisker pad skin and cold head-withdrawal reflex in the rats with Glu injection into the tongue.</p> <p>Conclusions</p> <p>The present findings suggest that peripheral Glu receptor mechanisms may contribute to cold hyperalgesia in the tongue but not in the facial skin, and also contribute to heat hyperalgesia in the tongue and facial skin, and that the mitogen-activated protein kinase cascade in Vc-C2 neurons may be involved in these Glu-evoked hyperalgesic effects.</p
Observation of Large CP Violation in the Neutral B Meson System
We present a measurement of the Standard Model CP violation parameter sin
2phi_1 based on a 29.1 fb^{-1} data sample collected at the Upsilon(4S)
resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider.
One neutral B meson is fully reconstructed as a J/psi Ks, psi(2S) Ks, chi_c1
Ks, eta_c Ks, J/psi K_L or J/psi K^{*0} decay and the flavor of the
accompanying B meson is identified from its decay products. From the asymmetry
in the distribution of the time intervals between the two B meson decay points,
we determine sin 2phi_1 = 0.99 +- 0.14(stat) +- 0.06(syst). We conclude that we
have observed CP violation in the neutral B meson system.Comment: 4 figures, to appear in Phys. Rev. Letter
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