Usage pattern of Library Resources and Services by the Students and Faculty Members of B.Ed Colleges Affiliated to Kuvempu University

This study explores user perception, the use of an academic library, and the correlation between user perception and library use. The findings indicate that the B.Ed College library is a preferred place to study and spend time during non-class times on campus. The frequent user activities in the library included individual study, reading, computer use, finding information, group study, using reference and information services, and meeting and socializing. The correlation between library use and each of the user activities was examined. The findings suggest that users perceive the B.Ed College library primarily as a place for learning and information seeking. The study shows how users perceive and use the library, and provides insights into how libraries can strengthen their place and advance their role in the academic community

ADAPTIVE NOISE SUPPRESSION IN VOICE COMMUNICATION USING ASSNFIS SYSTEM

The paper proposed the adaptive noise suppression technique for suppression of noise in voice communication. There are different techniques earlier used for adaptive filteration like least mean square, kalman’s filter etc.In the paper we used “fuzzy logic” technique for adaptive filteration. We know about the theory of adptive filteration of noise and application of fuzzy logic. We are using the fuzzy logic functions anfis and genfis1 by matlab for simulation. Anfis is the adaptive neuro-fuzzy training of sugeno-type fuzzy inference systems. In this paper we uses anfis system to suppress different types of noise from voice signal

The Extension of Generalized Intuitionistic Topological Spaces

In this paper, irresolute functions in generalized intuitionistic topological spaces were introduced. Regarding this function, some minimal and maximal irresolute functions were introduced. In addition, the generalized intuitionistic topological spaces were extended by using their open sets which is finer than of it and their basic characterizations were investigated. Also some continuous functions in extension of generalized intuitionistic topological spaces were discussed

ASSESSMENT OF MICROALBUMINURIA IN ESSENTIAL HYPERTENSIVES AND ITS RESPONSE TO ANGIOTENSIN-CONVERTING ENZYME INHIBITOR THERAPY

ABSTRACTObjective: Objective is to study the prevalence of microalbuminuria among patients suffering from essential hypertension and also to evaluate theresponse of microalbuminuria to angiotensin-converting enzyme (ACE) inhibitors therapy.Methods: The study conducted at Santosh Medical College and Hospital, Ghaziabad, on 300 patients with essential hypertension. After attainingbaseline parameters in all patients, those newly diagnosed essential hypertensives with microalbuminuria not on any treatment were started on anACE inhibitor (ramipril), for 8 weeks, after which all parameters were reassessed and comparison and statistical analysis were done to establish theprevalence of microalbuminuria and its response to therapy.Results: In our study, mean microalbuminuria excretion was 101.79 mcg/mg creatinine at the beginning of the study and 80.20 mcg/mg creatinineafter 8 weeks of ACE inhibitor therapy, with 21.2% fall rate.Conclusion: Microalbuminuria is an independent risk factor for the development or worsening of hypertensive nephropathy and endothelialdysfunction, thereby increasing the risk of micro- and macro-vascular complications.Keywords: Microalbuminuria, Essential hypertension, Angiotensin-converting enzyme inhibitor therapy

Self-Organization of Microcircuits in Networks of Spiking Neurons with Plastic Synapses

The synaptic connectivity of cortical networks features an overrepresentation of certain wiring motifs compared to simple random-network models. This structure is shaped, in part, by synaptic plasticity that promotes or suppresses connections between neurons depending on their joint spiking activity. Frequently, theoretical studies focus on how feedforward inputs drive plasticity to create this network structure. We study the complementary scenario of self-organized structure in a recurrent network, with spike timing-dependent plasticity driven by spontaneous dynamics. We develop a self-consistent theory for the evolution of network structure by combining fast spiking covariance with a slow evolution of synaptic weights. Through a finite-size expansion of network dynamics we obtain a low-dimensional set of nonlinear differential equations for the evolution of two-synapse connectivity motifs. With this theory in hand, we explore how the form of the plasticity rule drives the evolution of microcircuits in cortical networks. When potentiation and depression are in approximate balance, synaptic dynamics depend on weighted divergent, convergent, and chain motifs. For additive, Hebbian STDP these motif interactions create instabilities in synaptic dynamics that either promote or suppress the initial network structure. Our work provides a consistent theoretical framework for studying how spiking activity in recurrent networks interacts with synaptic plasticity to determine network structure

Impact of farmer producer organization on organic chilli production in Telangana, India

33-43Input intensive modern agriculture is adversely affecting human health and environment. Farmers of Telangana state have taken up organic chilli production with the assistance of FPOs. Primary data was collected from 120 farmers comprising 60 members and 60 non-members of FPO from two districts of Telangana through semi-structured interviews. The study found that the shift to organic chilli cultivation led to decrease in input use by 9.06% and yield by 23.4%. However, the gross return from organic chilli farming was 13.85% higher over that realised by non-members due to the efforts of FPOs. DEA analysis revealed that a higher proportion of member farmers (48%) had technical efficiency of more than 60% as compared to non-members (18%). FPOs were instrumental in reduction of transaction cost and number of intermediaries leading to the realization of a higher proportion of producer’s share in consumer’s rupee (65%). Discriminant function analysis revealed that the FPO promoting institutions (44%), ease of doing business (16%) and infrastructure facilities like storage, irrigation, electricity and credit have high influence on performance of the states with respect to FPOs

Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide

<p>Abstract</p> <p>Background</p> <p>The role of the diffusible messenger nitric oxide (NO) in the regulation of pain transmission is still a debate of matter, pro-nociceptive and/or anti-nociceptive. <it>S</it>-Nitrosylation, the reversible post-translational modification of selective cysteine residues in proteins, has emerged as an important mechanism by which NO acts as a signaling molecule. The occurrence of <it>S</it>-nitrosylation in the spinal cord and its targets that may modulate pain transmission remain unclarified. The "biotin-switch" method and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry were employed for identifying <it>S</it>-nitrosylated proteins.</p> <p>Results</p> <p>Here we show that actin was a major protein <it>S</it>-nitrosylated in the spinal cord by the NO donor, <it>S</it>-nitroso-<it>N</it>-acetyl-DL-penicillamine (SNAP). Interestingly, actin was <it>S</it>-nitrosylated, more in the S2 fraction than in the P2 fraction of the spinal homogenate. Treatment of PC12 cells with SNAP caused rapid <it>S</it>-nitrosylation of actin and inhibited dopamine release from the cells. Just like cytochalasin B, which depolymerizes actin, SNAP decreased the amount of filamentous actin cytoskeleton just beneath the membrane. The inhibition of dopamine release was not attenuated by inhibitors of soluble guanylyl cyclase and cGMP-dependent protein kinase.</p> <p>Conclusion</p> <p>The present study demonstrates that actin is a major <it>S</it>-nitrosylated protein in the spinal cord and suggests that NO directly regulates neurotransmitter release by <it>S</it>-nitrosylation in addition to the well-known phosphorylation by cGMP-dependent protein kinase.</p

PFCBAS: pairing free and provable certificate-based aggregate signature scheme for the e-healthcare monitoring system

Recently, one of the most popular technologies of the modern era, the Internet of Things, allows the deployment and usage of various real-time test beds in various smart applications. One such application is the e-healthcare, in which patients' healthcare related data are transmitted to the nearest base station and then to a local or remote server as per the requirements. The data related to patients' health are sensitive and need special protection, therefore, the integrity and authentication of the sources of data generation are paramount concerns. However, several authentication or signature schemes that have been introduced in the past for this purpose are ID-based or having certificate-less settings. In these settings, a central authority, known as a trusted authority (TA), creates and distributes the secret key of every user. Thus, knowing the secrete key by the TA is called key escrow problem. But, these proposed schemes suffer from key distribution problems, which limit their applications in various applications. To mitigate these issues, this paper presents a certificate-based pairing free aggregate signature scheme (CBPFAS). The proposed scheme uses the merits of public key cryptography (PKC) and identity-based PKC (IDBPKC). The scheme is proven to be unforgeable, assuming the hardness of elliptic curve discrete log problem (ECDLP). The performance analysis shows that the proposed CBPFAS scheme executes in 0.78(n+1) ms in comparison to 9.63+1.17n ms in [1], 9.63+0.78n ms in [2], 9.63+3.39n ms in [3], and 9.63+1.17n ms in [4]. From these results, it is concluded that the proposed pairing free certificate-based aggregate signature scheme performs better than its counterparts

Analytical Method Development and Validation for the Simultaneous Estimation of Aspirin, Clopidogrel and Rosuvastatin in Pharmaceutical Dosage Form

A new, simple, novel, accurate, precise, reliable, rapid and linear reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and fully validated for simultaneous qualitative and quantitative estimation of&nbsp;&nbsp; Rosuvastatin (ROS), Clopidogrel (CLOP) and Aspirin (ASP) in bulk and pharmaceutical dosage form as per International Conference on Harmonization (ICH) guidelines. In the present work, good chromatographic separation was achieved by isocratic method using a Hypersil BDS C18 column (250 mm ×4.6, 5 μm) and a mobile phase consisting of KH2Po4 buffer pH-6.0: acetonitrile in the ratio 60:40, at a flow rate of 1 ml/min. The effluents obtained were monitored at 242nm with the UV-visible detector. The calibration curves obtained were linear (r2=0.999) over the concentration range of 7.5-22.5μg/ml and 1-3μg/ml for CLOP, ASP and ROS respectively. A run time of 7.0 minutes for each sample made it possible to analyze more than 200 samples per day. The retention time of ASP, CLOP and ROS was found to be 3.103 min, 4,277 min and 5.707 min respectively. The high recovery values (99%-101%) indicate a satisfactory accuracy. The low percent relative standard deviation (% RSD) values in the precision study reveal that the method is precise&nbsp; therefore the method can be used for routine monitoring of CLOP, ASP and ROS in industry in the assay of bulk drug and dosage form. Keywords: RP-HPLC, Rosuvastatin, Clopidogrel, Aspirin, Method validation, ICH guidelines