A comparative study between proximal femur locking compression plate and dynamic hip screw fixation in management of intertrochantric femur fractures

Background: Proximal femur fractures are one of the commonest fracture encountered in orthopaedic trauma practice. Dynamic hip screw (DHS) is the gold standard procedure for treatment for stable intertrochanteric  fractures, however problem arises with unstable fractures in maintenance of neck shaft angle and proper reduction. Here we are giving results of trochanteric fractures treated with proximal femoral locking compression plate (PFLCP) as compared with dynamic hip screw (DHS).Methods: This study was a prospective study. Two groups of trochanteric fractures of 25 patients operated with DHS and LCP were taken. Each patient was followed-up from July 2011 to October 2012 for minimum of 12 month or till the bony union. Every fracture was classified according to AO classification. Functional results will be assessed as per modified Harris hip evaluation score.Results: Among 25 patient treated with PFLCP, length discrepancy was .857 cm while that for DHS was 1.2 cm. The mean time of unaided walking with LCP Was 14.20 weeks while for DHS it was 16.20 weeks. The mean varus angulation for LCP 8 degree while for DHS 10.2 degree. In LCP in 1 case screw cut out from head and neck of femur while in DHS, same is seen in 2 cases and in addition loss of position of lag screw seen in 5 cases.one case was found with superficial infection in LCP while in case of DHS 3 cases with deep infection for that implant was removed and 6 cases were found with superficial infection.Conclusions: Proximal femoral locking plate (PFLCP) is simple, stable for fixation with fewer complications, and is an effective method for unstable intertrochanteric fractures.  Comparing with DHS group, the locking plate has shorter operative time, fewer blood loss and drainage

Magnetic flux distorsion in two-phase liquid metal flow

A Generation IV Sodium cooled Fast Reactor (SFR) is being researched and developed at CEA, Cadarache France under the project named ASTRID. Monitoring gas presence in SFR is important with respect to its safe operation. In accordance with the principles of diversity, techniques based on different measurement principles have been proposed. This thesis concerns the detection and characterization of void using magnetic flux perturbation principle. An Eddy Current Flow Meter (ECFM) device is used for this purpose. From the technological point of view, the objective is to evaluate the feasibility of ECFM as a flow and/or void monitoring/characterizing device; and to determine which parameters are of interest and what are the precision of these measurements; and whether it is possible to measure the flow rate and void fraction simultaneously with the same ECFM device. From the physics point of view, the ECFM system involves the magnetic flux perturbation due to voids in the presence of Faraday induction and Lorentz force effects. Therefore ECFM integrated signal contains informations about the void, Faraday induction and Lorentz force effects based perturbation in magnetic flux and their couplings. Our objective is to understand the nature and extent of these couplings. Specific experiments have been developed to study the effects of flow velocity, void fraction and magnetic flux pulsations on the response of an ECFM. It consists in modeling the two-phase flow by a moving aluminium rod (plug flow) with holes and grooves to simulate voids. Flow velocity range of variation was 0<U<1 m/s, void fraction 0<<6.9% and pulsation 1500<<12000 rad/s (for this range of pulsations the electromagnetic skin depth is of order but smaller than the aluminium rod radius). An ellipse fitting method was proposed to analyze the output signal of the secondary coils. The results show that ECFM is sensitive to void fractions between 0.3 % and 6.9%. Furthermore, the response to void fraction is insensitive to the mean velocity of the twophase medium. A second approach based on demodulation analyses of the secondary coils output signal has been developed. We have proposed a theoretical model based on a first order expansion of magnetic flux in U and a. With this model it was possible to interpret the experimental results in terms of contributions of U and a. Despite the strong coupling between Faraday induction and Lorentz force effects, the results show that the contributions of U and a. can be well separated at low magnetic Reynolds number (Rem < 0.12) and low a values ( < 6.9%). A very important result is that the contribution of _ on magnetic flux is insensitive to variations of velocity in this range of Rem. Moreover, different geometries of void have been studied: grooves and holes. It was observed that the geometry of void do not change the variation of magnetic flux with a. This second approach revealed to be more sensitive to void fraction variations than ellipse fitting method. Finally, preliminary experiments with liquid metal galinstan with glass beads were done, which showed sensitivity of ECFM signal with velocity and void. In conclusion, this work has shown that ECFM can measure simultaneously void and velocity in the range of parameters studied, in particular 0.06%< < 6.9%

Use of Black Layer to Study Dry Matter Accumulation in Grain Sorghums

Agronom

Thermo-magnetic behaviour of AFM–MFM cantilevers

Atomic force microscopy (AFM) experiments were performed to study the behaviour of AFM cantilevers under an external magnetic field B and temperature field produced by a coil with an iron core. Four cantilever types were studied. Forces were measured for different B values and at various coil-to-cantilever separation distances. The results were analysed on the basis of a phenomenological model. This model contains the contribution of two terms, one monopole-monopole interaction at short distance, and one apparent paramagnetic interaction in del B-2 at large distance, which represents the temperature effects. We observe a good agreement between the model and the experimental data

ETHNOBOTANY IN RELATION TO LIVELIHOOD SECURITY IN DISTRICT BASTAR OF CHHATTISGARH STATE WITH SPECIAL REFERENCE TO NON -TIMBER FOREST PRODUCES

In present study ethnobotany in relation to livelihood security in district Bastar of Chhattisgarh state with special reference to non timber forest produces were found to collect variety of plant produces from forests, for their livelihood security. Those collected plant produces were non timber forest produces (NTFPs).In this research total 44 plants producing NTFP were noted to be collected by tribals in 20 villages of Bastar district.Plant and plant produce collected  by the tribals from the plants were seeds of 11 plants, fruits of 11, roots of 03, Rhizomes of 04,flowers of 04, secretory products from 03 plants, while 04 whole plants.Lakh and cocoons were also collected by the tribals from the forest.Beside collection of NTFPs,69 potential market place in Bastar district, where marketing of NTFPs was found maximum were also identified for the selling of plant produces

Novel long non-coding RNAs of relevance for ulcerative colitis pathogenesis

Background and aims: The study aimed to identify yet unknown and uncharacterized long non-coding RNAs (lncRNAs) in treatment-naïve ulcerative colitis (UC), and to define their possible roles in UC pathogenesis. For that purpose, accurate quantification methods for lncRNA transcript detection, multiple and “stringent” strategies were applied. New insights in the regulation of functional genes and pathways of relevance for UC through expression of lncRNAs are expected. Methods: The study was based on sequencing data derived from a data set consisting of treatment-naïve UC patients (n = 14) and control subjects (n = 16). Two complementary aligners were used to identify lncRNAs. Several different steps were used to validate differential expression including plotting the reads over the annotation for manual inspection. To help determine potential lncRNA involvement in biological processes, KEGG pathway enrichment was done on protein-coding genes which co-expressed with the lncRNAs. Results: A total of 99 lncRNAs were identified in UC. The lncRNAs which were not previously characterized (n = 15) in UC or other autoimmune diseases were selected for down-stream analysis. In total, 602 protein-coding genes correlated with the uncharacterized lncRNAs. KEGG pathway enrichment analysis revealed involvement of lncRNAs in two significantly enriched pathways, lipid and atherosclerosis, and T-cell receptor signaling. Conclusion: This study identified a set of 15 yet uncharacterized lncRNAs which may be of importance for UC pathogenesis. These lncRNAs may serve as potential diagnostic biomarkers and might be of use for the development of UC treatment strategies in the future

Magnetic flux distortion in two-phase liquid metal flow: Model experiment

In this paper, we present the model experiments in order to study the magnetic flux distortion of a two-phase liquid metal flow excited by an AC magnetic field in a range of pulsation where Faraday induction and Lorentz force effects are significant. These experiments realized with solid aluminum rods allow to characterize the effects of flow velocity (0 ≲ U≤1 ms−1), void fraction (0≤α≤6.9 %), pulsation of the AC magnetic field (1.5×103≤ω≤12.5×103 rad s−1), and of two different void geometries. The results are analyzed on the basis of a first order expansion of magnetic flux in U and α. Despite the strong coupling between Faraday induction and Lorentz force effects, the results show that the contributions of U and α on a magnetic flux distortion can be well separated at both low magnetic Reynolds number and α values. These results are independent of void geometry

Novel long-coding RNAs of relevance for ulcerative colitis pathogenesis

Poster presented at the Norwegian Bioinformatics Days 2022, Sundvolden, 28-30 September 2022.Introduction - LncRNAs have become a growing field of research. They are involved in diverse biological processes including expression regulation, and chromatin modification. Many lncRNAs have been characterized as involved in the occurrence and development of various human diseases, including cancer. A growing body of evidence implies a role for lncRNAs in UC by modulating the intestinal barrier, regulating the expression of inflammatory cytokines, and polarization of macrophages. Problems - Accurate quantification of lncRNA transcripts is challenging due to the low expression of lncRNAs, and their exons overlap protein-coding exons on the same strand. Aims - The study aimed to define the role of uncharacterized long noncoding RNAs (lncRNAs) in treatment-naïve ulcerative colitis (UC). Method - To overcome difficulties in lncRNA transcript quantification, multiple and “stringent” strategies were applied. New insights in the regulation of functional genes and pathways of relevance for UC through expression of lncRNAs are expected Conclusion - This study identified a set of 15 yet uncharacterized lncRNAs which may be of importance for UC pathogenesis. These lncRNAs may serve as potential diagnostic biomarkers and might be of use for the development of UC treatment strategies in the future. The proposed method can also be helpful to quantify low expressed lncRNA transcripts in other datasets

Epstein Barr virus induced pneumonitis: a rare entity in immunocompetent baby

Acute infectious interstitial pneumonitis (IP) (Epstein Barr virus (EBV)-associated IP) in children has been most commonly associated with human immunodeficiency virus (HIV) infection and immunocompromised hosts. Here we report a case of EBV-associated interstitial pneumonitis with cervical lymphadenopathy in an immunocompetent child. Patient underwent extensive routine and serologic workup which revealed positive polymerase chain reaction (PCR) for EBV, pointing towards the diagnosis of EBV induced pneumonitis. It is a very rare entity and is hardly seen among immunocompetent individuals especially young children. The aim of this case report is to bring to our notice that among all described pneumonias, EBV induced pneumonitis can be a possibility while dealing with lung infections

Cost variation among antiretroviral drugs: pharamcoeconomical prospective

Background: Acquired immunodeficiency syndrome (AIDS) is a disorder caused by the human immunodeficiency virus (HIV). Main characteristic feature of AIDS includes severe immunosuppression which leads to opportunistic infections which is a main cause of death and requires a lifelong therapy. There exists wide range of cost variation in antiretroviral drugs that are marketed in India. The current study aims to view the existing situation of antiretroviral drugs, by collecting data about the cost of common antiretroviral drugs available either singly or in combination and to evaluate the difference in cost of different brands of same active drug by calculating percentage cost variation.Methods: Data for calculating cost ratio and percentage price variation of various antiretroviral drugs was obtained from “Current Index of Medical Specialties” October 2017-January2018.Results: Zidovudine 100mg shows maximum cost ratio and price variation followed by Lamivudin 100mg in the single drug therapy. Lamivudine 150mg + Zidovudine 300mg shows maximum price variation in combination drug therapy.Conclusions: Indian market shows wide price variation of different brands of the same generic antiretroviral drug. To decrease the wide cost variation among different brands of antiretroviral drugs; it is time to create awareness among healthcare professionals about impact of cost effectiveness of drug regimen and decrease the financial burden on the patients