Automated RTL generator

Code generation is a vast topic and has been discussed and implemented for quite a while now. It has been also been a topic of debate as to what is an ideal code generator and how an ideal code generator can be created. The biggest challenge while creating a code generator is to maintain a balance between the amount of freedom given to the user and the restrictions imposed on the code generated. These two seemed to be very conflicting requirements while designing the Automated RTL Code Generator. If the code generator tries to be rigid and sticks to well-defined paths and restricted code, the flexibility provided to the also reduces. It is a very interesting task to strike the right amount of balance and generate code of high quality and well-defined standards. Verilog code is a type of RTL (Register Transfer Level) that itself has fewer constructs and variety as compared to pure software languages like Java, or Python so it makes sense to generate it automatically so that the hardware designers are relieved from the mundane tasks of writing repetitive verilog code modules. Also code generator provides a nice introduction to the much wider topic of compiler design. This project also tries to delve deeper into the latest IPXACT XML standard IEEE 1865-2009 which is used for hardware description and will provide means of generating verilog code directly from it

Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication.

Diabetes is associated with loss of functional pancreatic β-cells, and restoration of β-cells is a major goal for regenerative therapies. Endogenous regeneration of β-cells via β-cell replication has the potential to restore cellular mass; however, pharmacological agents that promote regeneration or expansion of endogenous β-cells have been elusive. The regenerative capacity of β-cells declines rapidly with age, due to accumulation of p16(INK4a), resulting in limited capacity for adult endocrine pancreas regeneration. Here, we show that transforming growth factor-β (TGF-β) signaling via Smad3 integrates with the trithorax complex to activate and maintain Ink4a expression to prevent β-cell replication. Importantly, inhibition of TGF-β signaling can result in repression of the Ink4a/Arf locus, resulting in increased β-cell replication in adult mice. Furthermore, small molecule inhibitors of the TGF-β pathway promote β-cell replication in human islets transplanted into NOD-scid IL-2Rg(null) mice. These data reveal a novel role for TGF-β signaling in the regulation of the Ink4a/Arf locus and highlight the potential of using small molecule inhibitors of TGF-β signaling to promote human β-cell replication

Effect of Wind Load on Structural Performance of Dimensionally Regular & Irregular High rise Buildings with different Outrigger Systems

Outriggers system is used as one of the best way of increasing the lateral stiffness and has been generally utilized in tall building structures. The outrigger system is very effective in increasing structure’s flexural stiffness. It is likewise viable in decreasing the horizontal top deflection and bending moments in the core of high-rise frame-core structures. This study presents the detailed analysis on how the top drift, inter-story drift, base moment in the core are influenced by the outriggers stiffness, outriggers optimum locations, columns axial stiffness and foundations flexibility. outrigger braced structures can strengthen a structure without disturbing its aesthetic appearance and this is a significant advantage over other lateral load resisting systems. The thesis compare between many outriggers systems including both concrete & steel Outriggers. The Rectangular shape & L- shaped building structures are taken for analysis. The study also presents simplified procedure to optimize the location of the outriggers that will result in a maximum reduction in the lateral displacement at the top of the building. The modeling of the structure is done using “ETABS” program. The investigation of the model is completed by comparable static technique. Finally, the thesis proposed a simplified analysis for outriggers structures with core for both regular and irregular high rise building

Inundation Risk due to a Landslide-Generated Tsunami in the North Sea

Water Qualit

Human β-Cell Proliferation and Intracellular Signaling: Driving in the Dark Without a Road Map

A major goal in diabetes research is to find ways to enhance the mass and function of insulin secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even reverse overt diabetes. In this Perspectives in Diabetes article, we highlight the contrast between the relatively large body of information that is available in regard to signaling pathways, proteins, and mechanisms that together provide a road map for efforts to regenerate β-cells in rodents versus the scant information in human β-cells. To reverse the state of ignorance regarding human β-cell signaling, we suggest a series of questions for consideration by the scientific community to construct a human β-cell proliferation road map. The hope is that the knowledge from the new studies will allow the community to move faster towards developing therapeutic approaches to enhance human β-cell mass in the long-term goal of preventing and/or curing type 1 and type 2 diabetes