Pretransplant uric acid levels may be predictive for prognosis of renal transplant donors

Background The living kidney donor counseling prior to the operation may be helpful to learn how to properly care for the remaining single kidney for the rest of their lives. Worsening kidney function is associated with elevated serum uric acid (UA) levels. In this study, we compared the baseline laboratory findings of renal transplant donors with their follow-up laboratory values. Methods The study consisted of 173 adult donors including 91 females and 82 males with a mean age of 46.82 +/- 11.31 years. The follow-up clinical and laboratory examinations were performed on the third day at the end of the first and the sixth months of the surgery. According to donor's creatinine levels we constituted two groups: high creatinine and normal creatinine. Results Patients within the high creatinine group had significantly higher mean serum UA levels when compared with the normal creatinine group. In multivariate analysis, among the other effective variables, UA level alone was found to be the most effective parameter predicting the post-transplant creatinine levels (p = 0.004, odds ratio: 12.4, 95% CI: 2.3-68.3) at sixth month post-transplantation. In the ROC analysis for the effects of UA, the following cutoff values were found: >6 mg/dL in men (sensitivity 81.3%, specificity 76.9%, positive predictive value 89.7%, negative predictive value 62.5%, accuracy 80%) and >= 5 mg/dL in women (sensitivity 72.2, specificity 74.4%, positive predictive value 89.7%, negative predictive value 62.5%, accuracy: 73.7%). Conclusion Pretransplant serum UA levels can give important clues regarding the renal functions of the donors during the postoperative period

Vitamin D receptor gene polymorphisms, bone mineral density and bone turnover: Fok-I genotype is related to postmenopausal bone mass in essantial hypertension

43rd ERA-EDTA Congress -- JUL 15-18, 2006 -- Glasgow, SCOTLANDWOS: 000239919002232ERA, EDT

Prominent J Wave (Osborn Wave) with Coincidental Hypothermia in a 64-Year-Old Woman

WOS: 000227407000028PubMed: 1590283

The relationship of vitamin D receptor gene polimorphism with bone scintigraphy in peritoneal dialysis patients

44th ERA-EDTA Congress -- JUN 22-24, 2007 -- Barcelona, SPAINWOS: 000253320600853ERA-EDT

Effect serum and angiotensin-converting enzyme gene polymorphism, on ambulatory blood pressure changes and Vitamin D levels in essantial hypertension

43rd ERA-EDTA Congress -- JUL 15-18, 2006 -- Glasgow, SCOTLANDWOS: 000239919002223ERA, EDT

Analysis of glomerular filtration rate, serum cystatin C levels, and renal resistive index values in cirrhosis patients

Background: The aim of this study was to evaluate the relation of glomerular filtration rate (GFR) to serum cystatin C levels, renal resistive index (RRI), serum creatinine and creatinine clearance in patients with different stages of cirrhosis. Methods: The study sample was 25 cirrhotic patients (10 females and 15 males; mean age 57.3±2.04 years), 10 in the compensated stage without ascites and 15 in the decompensated stage with new-onset ascites. None had azotemia nor were on diuretic treatment. The control group comprised 25 healthy adults (11 female and 14 men; mean age 56.56±1.91 years). Serum cystatin C, RRI, serum creatinine and creatinine clearance were measured. GFR was determined by technetium99m-diethylene triamine pentaacetic acid renal scintigraphy. Results: Cirrhosis cases had lower mean scintigraphic GFR than controls (64.5±4.03 vs. 87.96±4.16 mL/min, p<0.05). Serum cystatin C and RRI were significantly higher in the cirrhotic group compared to controls (1.16±0.09 mg/L and 0.68±0.01 vs. 0.86±0.03 mg/L and 0.64±0.01, respectively; p<0.05). Subgroup comparative analysis showed that only two parameters, scintigraphic GFR and serum cystatin C, were significantly different between compensated and decompensated cirrhotics (75.62±4.9 mL/min and 0.89±0.07 mg/L vs. 57.23±5.14 mL/min and 1.34±0.13mg/L, respectively; p<0.05). Scintigraphic GFR showed significant correlation with cystatin C, but not with serum creatinine or creatinine clearance (r=–0.877, p<0.05) in decompensated patients. No correlation was observed between scintigraphic GFR and RRI or between serum cystatin C and RRI in all subjects. A receiver operator characteristics curve showed that cystatin C at a cutoff value of 1.01 mg/L can significantly differentiate patients with GFR <70 mL/min with 80% sensitivity and 80% specificity. Conclusions: Serum cystatin C, but not serum creatinine or RRI measurement, correlates with GFR in each stage of liver failure and has a significant diagnostic advantage in detecting lower GFR in such cases

The contribution of extrarenal tissues to oxidative stres, in an experimental model of renal ischemia and reperfusion injury

44th ERA-EDTA Congress -- JUN 22-24, 2007 -- Barcelona, SPAINWOS: 000253320600679ERA-EDT

Protective effect of erythropoietin against lipid peroxidation on a renal ischemia and reperfusion injury model

44th ERA-EDTA Congress -- JUN 22-24, 2007 -- Barcelona, SPAINWOS: 000253320600686ERA-EDT

The relationship between the peritoneal permeability and serum cholesterol levels

43rd Annual Congress of the European-Renal-Association/European-Dialysis-and-Transplant-Association (ERA-EDTA) -- JUL 15-18, 2006 -- Glasgow, SCOTLANDWOS: 000239919001411European Renal Assoc, European Dialys & Transplant Asso

Oxidized LDL accumulation in experimental renal ischaemia reperfusion injury model

43rd ERA-EDTA Congress -- JUL 15-18, 2006 -- Glasgow, SCOTLANDWOS: 000239919002077ERA, EDT