2,756 research outputs found
Unifying metastasis--Integrating intravasation, circulation and end organ colonization
Recent technological advances that have enabled the measurement of circulating tumour cells (CTCs) in patients have spurred interest in the circulatory phase of metastasis. Techniques that do not solely rely on a blood sample allow substantial biological interrogation beyond simply counting CTCs
Pollution Trading and Environmental Injustice: Los Angeles’ Failed Experiment in Air Quality Policy
Complex Independent Component Analysis of Frequency-Domain Electroencephalographic Data
Independent component analysis (ICA) has proven useful for modeling brain and
electroencephalographic (EEG) data. Here, we present a new, generalized method
to better capture the dynamics of brain signals than previous ICA algorithms.
We regard EEG sources as eliciting spatio-temporal activity patterns,
corresponding to, e.g., trajectories of activation propagating across cortex.
This leads to a model of convolutive signal superposition, in contrast with the
commonly used instantaneous mixing model. In the frequency-domain, convolutive
mixing is equivalent to multiplicative mixing of complex signal sources within
distinct spectral bands. We decompose the recorded spectral-domain signals into
independent components by a complex infomax ICA algorithm. First results from a
visual attention EEG experiment exhibit (1) sources of spatio-temporal dynamics
in the data, (2) links to subject behavior, (3) sources with a limited spectral
extent, and (4) a higher degree of independence compared to sources derived by
standard ICA.Comment: 21 pages, 11 figures. Added final journal reference, fixed minor
typo
A Facile Method for Separation of the Cryptic Methionine Sulfoxide Diastereomers, Structural Assignment and DFT Analysis
Methionine (Met) oxidation is an important biological redox node, with hundreds if not thousands of protein targets. The process yields methionine oxide (MetO). It renders the sulfur chiral, producing two distinct, diastereomerically related products. Despite the biological significance of Met oxidation, a reliable protocol to separate the resultant MetO diastereomers is currently lacking. This hampers our ability to make peptides and proteins that contain stereochemically defined MetO to then study their structural and functional properties. We have developed a facile method that uses supercritical CO₂ chromatography and allows obtaining both diastereomers in purities exceeding 99 %. ¹H NMR spectra were correlated with X‐ray structural information. The stereochemical interconversion barrier at sulfur was calculated as 45.2 kcal mol⁻¹, highlighting the remarkable stereochemical stability of MetO sulfur chirality. Our protocol should open the road to synthesis and study of a wide variety of stereochemically defined MetO‐containing proteins and peptides
The Architecture of the GW Ori Young Triple Star System and Its Disk: Dynamical Masses, Mutual Inclinations, and Recurrent Eclipses
We present spatially and spectrally resolved Atacama Large
Millimeter/submillimeter Array (ALMA) observations of gas and dust orbiting the
pre-main sequence hierarchical triple star system GW Ori. A forward-modeling of
the CO and CO =2-1 transitions permits a measurement of
the total stellar mass in this system, , and the
circum-triple disk inclination, . Optical spectra spanning
a 35 year period were used to derive new radial velocities and, coupled with a
spectroscopic disentangling technique, revealed that the A and B components of
GW Ori form a double-lined spectroscopic binary with a day
period; a tertiary companion orbits that inner pair with a day
period. Combining the results from the ALMA data and the optical spectra with
three epochs of astrometry in the literature, we constrain the individual
stellar masses in the system (,
, ) and
find strong evidence that at least one (and likely both) stellar orbital planes
are misaligned with the disk plane by as much as . A -band light
curve spanning 30 years reveals several new 30 day eclipse events
0.1-0.7~mag in depth and a 0.2 mag sinusoidal oscillation that is clearly
phased with the AB-C orbital period. Taken together, these features suggest
that the A-B pair may be partially obscured by material in the inner disk as
the pair approaches apoastron in the hierarchical orbit. Lastly, we conclude
that stellar evolutionary models are consistent with our measurements of the
masses and basic photospheric properties if the GW Ori system is 1 Myr
old.Comment: 26 pages, 15 figures, accepted to Ap
Constraining the period of the ringed secondary companion to the young star J1407 with photographic plates
Context. The 16 Myr old star 1SWASP J140747.93-394542.6 (V1400 Cen) underwent
a series of complex eclipses in May 2007, interpreted as the transit of a giant
Hill sphere filling debris ring system around a secondary companion, J1407b. No
other eclipses have since been detected, although other measurements have
constrained but not uniquely determined the orbital period of J1407b. Finding
another eclipse towards J1407 will help determine the orbital period of the
system, the geometry of the proposed ring system and enable planning of further
observations to characterize the material within these putative rings. Aims. We
carry out a search for other eclipses in photometric data of J1407 with the aim
of constraining the orbital period of J1407b. Methods. We present photometry
from archival photographic plates from the Harvard DASCH survey, and Bamberg
and Sonneberg Observatories, in order to place additional constraints on the
orbital period of J1407b by searching for other dimming and eclipse events.
Using a visual inspection of all 387 plates and a period-folding algorithm we
performed a search for other eclipses in these data sets. Results. We find no
other deep eclipses in the data spanning from 1890 to 1990, nor in recent
time-series photometry from 2012-2018. Conclusions. We rule out a large
fraction of putative orbital periods for J1407b from 5 to 20 years. These
limits are still marginally consistent with a large Hill sphere filling ring
system surrounding a brown dwarf companion in a bound elliptical orbit about
J1407. Issues with the stability of any rings combined with the lack of
detection of another eclipse, suggests that J1407b may not be bound to J1407.Comment: 8 pages, 3 tables, 4 figures, accepted for publication in A&A. LaTeX
files of the paper, scripts for the figures, and a minimal working FPA can be
found under https://github.com/robinmentel/Constraining-Period
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