北海道医療大学病院インプラント歯科外来の現状

北海道医療大学病院は,2005年7月1日に設備拡充して,新しくスタートした.今回,我々は,2005年7月から2006年6月の1年間に北海道医療大学病院インプラント歯科外来を受診した患者の実態を調査したので報告する.インプラント歯科外来受診者数は,51名であり,紹介患者は24名で紹介率は47%であった.インプラント手術を施行した患者は,49症例であった.インプラント手術件数は67件であり,インプラント埋入本数は201本であった.入院してインプラント手術を施行した症例は63件であった.麻酔方法は,静脈内鎮静法を併用した症例が多く,62/67症例で92.5%であった.インプラントクリニカルパスに従い,インプラント治療を行っており,患者の満足度と安心感に貢献できた治療が可能になったと考える.また,開業医でもインプラント治療が行われるようになり,それら病院より患者の紹介も増加することが予想され,さらに治療のレベルを向上させ,スタッフの充実を図る必要性が考えられた.Hospital of Health Sciences University of Hokkaido was expanded newly on July 1, 2005 and started as a new hospital. At the same time, the facilities and stuff of clinical department of implant dentistry were strengthened remarkably. In late years, the enlightenment spread to patients, who were lost of the teeth, to implant treatment spreads, and come to have a large the expectation degree of the patients. At this time, we have reported having a medical examination status of the implant patients from July, 2005 to June, 2006. We present Hospital of Health Sciences University of Hokkaido Clinical department of implant dentistry outpatient this time between one year of June, 2006 since July, 2005 because the reality of the patient who had a checkup was investigated. Clinical department of implant dentistry examination several were 51 patients, and the introduction patient was 24 patients, and the introduction rate was 47%. Patient who performed implant operation was 49 cases. Case of Implant operation was 67 cases, and implant installed numbers were 201 fixtures. The case that the patients was hospitalized, and performed implant operation was 63 cases. There was much case that used with the intravenous sedation, and the anesthesia cases were 92.5% in 62/67 cases. An implant clinical path is followed, and an implant treatment is being done, and it is thought that satisfaction of the patient and the treatment that were able to contribute to a feeling of relief were enabled. In addition, did an implant treatment with a practicing physician, and that introduction of the patient from the hospital increased was expected, and a more therapeutic level was improved, and necessity to plan substantiality of staff was thought about

早期負荷インプラント用カスタムトレーについて

This clinical report discusses a custom made tray used for fabrication of the superstructure of early load implants. The activities of the dental technician impressions and bite taking simultaneously in implant operations. The results of the observations led to the manufacture of a custom made tray with a duplicate denture made from the full denture used. The bite-seating impression was performed with the custom made tray, and the superstructure was installed in four treatment days. The progress is excellent, and the patient expresses satisfaction with the result. As a result of this study, it was possible to made the bite-seating impression by the full denture in use. After the operation, the superstructure could be made in a short time. Only very small adjustments of the vertical dimension and horizontal position were necessary because the custom made tray made from a duplicate denture

The Crystal Structure of Ramsdellite from Pirika Mine

Chemical composition and crystal structure of ramsdellite from Pirika mine, Hokkaido, Japan were studied. Chemical composition, determined by EPMA, shows that ramsdellite is pure manganese oxide and does not contain any other element. The crystallographic data, obtained by Rietveld analysis, indicate that ramsdellite has orthorhombic symmetry. Space group is Pnma and unit cell parameters are: a=4.513(1)Å, b=9.264(1)Å and c=2.859(1)Å. The structure consists of MnO6 double chains (Byström, 1950). There are 4 symmetry-dependent MnO6 octahedral in an unit cell and 2 symmetry-independent oxygen atoms in an MnO6 octahedron. The difference of inter-atomic distances between Mn-O(1) and Mn-O(2) is larger than other manganese dioxide minerals. The distortion of MnO6 octahedron is quite similar to that of groutite (α-MnOOH). These data suggest that ramsdellite was formed by oxidation of groutite

GPU-based image reconstruction method including geometrical detector response functions for OpenPET

The OpenPET, which has a physical gap between two detector rings, is our new geometry. In order to realize future radiation therapy guided by OpenPET, real-time imaging is required. Therefore we developed a list-mode image reconstruction method using general purpose graphic processing units (GPUs). For GPU implementation, the efficiency of acceleration depends on the implementation method which is required to avoid conditional statements. In this paper, therefore, we developed a new system model suitable for GPU implementation. In the proposed system model, each element of system matrix was calculated as the value of detector response function (DRF) of the length between the center of a voxel and a line of response (LOR). The DRF, which was calculated analytically to represent the probability distribution of each LOR, was modeled by a sixth-order polynomial function. The system model enabled us to calculate each element of the system matrix with reduced number of the conditional statements. We used the list-mode dynamic row-action maximum likelihood algorithm (DRAMA) which could reduce the number of iterations to only one. We applied the developed method to a small OpenPET prototype, which was developed for a proof-of-concept. The results showed that high quality reconstructed images were obtained using the proposed system model with 14.8 times faster than using the conventional system model.International Forum on Medical Imaging in Asi

GPU-Based PET Image Reconstruction Using an Accurate Geometrical System Model

In positron emission tomography (PET), 3D iterative image reconstruction methods have a huge computational burden. In this paper, we developed a list-mode image reconstruction method using graphics processing units (GPUs). Efficiency of acceleration for GPU implementation largely depends on the method chosen, where a reduced number of conditional statements and a reduced memory size are required. On the other hand, accurate system models are required to improve the quality of reconstructed images. Various accurate system models for conventional CPU implementation have been proposed, but these models basically require many conditional statements and huge memory size. Therefore, we developed a new system model which matches GPU implementation better. In this model, the detector response functions, which vary depending on each line of response (LOR), are pre-computed in CPUs and modeled by sixth-order polynomial functions in order to reduce the memory size occupied in GPUs. Each element of a system matrix is obtained on-the-fly in GPUs by calculating the distance between an LOR and a voxel. Therefore the developed system model enables efficient GPU implementation of the accurate system modeling with a reduced number of conditional statements and a reduced memory size. We applied the developed method to a small OpenPET prototype, in which 4-layered depth-of-interaction (DOI) detectors were used. For image reconstruction, we used the dynamic row-action maximum likelihood algorithm (DRAMA). Compared with a conventional model for GPU implementation, in which DRFs are given as a Gaussian function of fixed width, we saw no remarkable difference for DOI data, but for non-DOI data the proposed model outperformed the conventional at the peripheral region of the field-of-view. The proposed model had almost the same calculation time as the conventional model did. For further acceleration, we tried parallel GPU implementation, and we obtained 3.8-fold acceleration by using 4 GPUs

Restoration of the Analytically Reconstructed OpenPET Images by the Method of Convex Projections

We have proposed the OpenPET geometry which has gaps between detector rings and physically opened field-of-view. The image reconstruction of the OpenPET is classified into an incomplete problem because it does not satisfy the Orlov\u27s condition. Even so, the simulation and experimental studies have shown that applying iterative methods such as the maximum likelihood expectation maximization (ML-EM) algorithm successfully reconstruct images in the gap area. However, the imaging process of the iterative methods in the OpenPET imaging is not clear. Therefore, the aim of this study is to analytically analyze the OpenPET imaging and estimate implicit constraints involved in the iterative methods. To apply explicit constraints in the OpenPET imaging, we used the method of convex projections for restoration of the images reconstructed by the analytical way in which low-frequency components are lost. Numerical simulations showed that the similar restoration effects are involved both in the ML-EM and the method of convex projections. Therefore, the iterative methods have advantageous effect of restoring lost frequency components of the OpenPET imaging.Fully ３D　１

A randomized, double-blind study to evaluate the acid-inhibitory effect of vonoprazan (20 mg and 40 mg) in patients with proton-pump inhibitor-resistant erosive esophagitis

Background: Standard treatment for patients with erosive esophagitis (EE) is proton-pump inhibitors (PPIs), but some patients are resistant to PPIs. We aimed to evaluate the acid-inhibitory effects and efficacy of a novel potassium-competitive acid blocker (vonoprazan) in patients with PPI-resistant EE. Methods This randomized, double-blind, multicenter study of vonoprazan evaluated gastric and esophageal pH over a 24-hour period as the primary endpoint and EE healing rate as the secondary endpoint. Following a 7 to 14-day run-in period (lansoprazole 30 mg treatment), patients with endoscopically confirmed PPI-resistant EE received vonoprazan 20 mg or 40 mg for 8 weeks. Results Patients were randomized to receive vonoprazan 20 mg ( n = 9) or 40 mg ( n = 10). Over a 24-hour period; both groups showed a significant increase from baseline in the percentage of time gastric pH ≥ 4, referred to as pH 4 holding time ratio (HTR): an increase from 73.21% to 96.46% in the 20 mg group, and from 69.97% to 100.00% in the 40 mg group. Increases from baseline in esophageal pH 4 HTRs were not significant. The 40 mg group showed greater increases in gastric and esophageal pH 4 HTRs compared with the 20 mg group, but differences between groups were not significant. After 8 weeks’ treatment, the healing rate in subjects with baseline EE grades A–D was 60.0% (3/5 patients) in the 20 mg group and 71.4% (5/7 patients) in the 40 mg group. Vonoprazan was generally well tolerated. One patient (40 mg group) experienced four treatment-emergent adverse events (TEAEs) (unrelated to study drug), leading to study discontinuation. Conclusions Vonoprazan 20 mg and 40 mg effectively inhibited gastric acid secretion over a 24-hour period with significantly increased gastric pH 4 HTR, and resulted in an EE healing rate > 60.0% in this study. Vonoprazan treatment may be valuable for patients with PPI-resistant E