A simple algorithm for automatic Feynman diagram generation

An algorithm for the automatic Feynman diagram (FD) generation is presented in this paper. The algorithm starts directly from the definition formula of FD, and is simple in concept and easy for coding. The symmetry factor for each FD is naturally generated. It is expected to bring convenience for the researchers who are studying new calculation techniques or making new calculation tools and for the researchers who are studying effective field theory. A C-program made from the algorithm is also presented, which is short, fast, yet very general purpose: it receives arbitrary user defined model and arbitrary process as input and generates FD's at any order.Comment: 11 pages, 2 figure

A toxicogenomic data space for system-level understanding and prediction of EDC-induced toxicity.

Endocrine disrupting compounds (EDCs) are a persistent threat to humans and wildlife due to their ability to interfere with endocrine signaling pathways. Inspired by previous work to improve chemical hazard identification through the use of toxicogenomics data, we developed a genomic-oriented data space for profiling the molecular activity of EDCs in an in silico manner, and for creating predictive models that identify and prioritize EDCs. Predictive models of EDCs, derived from gene expression data from rats (in vivo and in vitro primary hepatocytes) and humans (in vitro primary hepatocytes and HepG2), achieve testing accuracy greater than 90%. Negative test sets indicate that known safer chemicals are not predicted as EDCs. The rat in vivo-based classifiers achieve accuracy greater than 75% when tested for invitro to in vivoextrapolation. This study reveals key metabolic pathways and genes affected by EDCs together with a set of predictive models that utilize these pathways to prioritize EDCs in dose/time dependent manner and to predict EDCevokedmetabolic diseases

Generating Functional for Strong and Nonleptonic Weak Interactions

The generating functional for Green functions of quark currents is given in closed form to next-to-leading order in the low-energy expansion for chiral SU(3), including one-loop amplitudes with up to three meson propagators. Matrix elements and form factors for strong and nonleptonic weak processes with at most six external states can be extracted from this functional by performing three-dimensional flavour traces. To implement this procedure, a Mathematica program is provided that evaluates amplitudes with at most six external mesons, photons (real or virtual) and virtual W (semileptonic form factors). The program is illustrated with several examples that can be compared with existing calculations.Comment: 26 pages; references added, comparison with other programs added, small changes in the text, version to appear in JHE

CalcHEP 3.4 for collider physics within and beyond the Standard Model

We present version 3.4 of the CalcHEP software package which is designed for effective evaluation and simulation of high energy physics collider processes at parton level. The main features of CalcHEP are the computation of Feynman diagrams, integration over multi-particle phase space and event simulation at parton level. The principle attractive key-points along these lines are that it has: a) an easy startup even for those who are not familiar with CalcHEP; b) a friendly and convenient graphical user interface; c) the option for a user to easily modify a model or introduce a new model by either using the graphical interface or by using an external package with the possibility of cross checking the results in different gauges; d) a batch interface which allows to perform very complicated and tedious calculations connecting production and decay modes for processes with many particles in the final state. With this features set, CalcHEP can efficiently perform calculations with a high level of automation from a theory in the form of a Lagrangian down to phenomenology in the form of cross sections, parton level event simulation and various kinematical distributions. In this paper we report on the new features of CalcHEP 3.4 which improves the power of our package to be an effective tool for the study of modern collider phenomenology.Comment: 82 pages, elsarticle LaTeX, 7 Figures. Changes from v1: 1) updated reference list and Acknowledgments; 2) 2->1 processes added to CalcHEP; 3) particles decay (i.e. Higgs boson) into virtual W/Z decays added together with comparison to results from Hdecay package; 4) added interface with Root packag

A Recursive Method to Calculate UV-divergent Parts at One-Loop Level in Dimensional Regularization

A method is introduced to calculate the UV-divergent parts at one-loop level in dimensional regularization. The method is based on the recursion, and the basic integrals are just the scaleless integrals after the recursive reduction, which involve no other momentum scales except the loop momentum itself. The method can be easily implemented in any symbolic computer language, and an implementation in Mathematica is ready to use.Comment: 10 pages, 1 figure, typos fixed, to appear in Computer Physics Communication

Next-to-Leading Order QCD corrections to BBˉB\bar B-mixing and ϵK\epsilon_K within the MSSM

We present a calculation of the QCD correction factors $\eta_{2B}$ and $\eta_{2K}$ up to Next-to-Leading Order within the MSSM. We took into account the region of low $\tan\beta$ for the Higgs- and chargino sector while neglecting the effect of gluinos and neutralinos.Comment: 38 pages, references added, typos corrected, extended discussion of gluino-mediated correction

From development to implementation with a fully integrated downstream bioprocess

Boehringer Ingelheim and Pfizer have developed a unique continuous bioprocess consisting of a short duration perfusion upstream and fully integrated downstream. The process is designed to generate at least 1 kg of material from a 100 L bioreactor in approximate 2 weeks. The upstream strategy utilizes a non-steady state, short duration perfusion process to achieve volumetric productivities ranging from 0.5 to 4 g/L/day. This creates a unique challenge for the downstream process as the titer and impurity load change over the duration of the culture. To accommodate upstream, a fully integrated downstream process was created using a combination of traditional batch unit operations and continuous bioprocessing. The system design includes a pair of small proteins A columns operated consecutively, a continuous low pH inactivation chamber (cVI), an anion exchange chromatography column, a single pass tangential flow filter, a virus filter and batch UFDF. The key to the system is three distinct operation modes including continuous, periodic and batch phases. The resulting hybrid system provides flexible and robust downstream processing of the continuous perfusion bioreactor. We have successfully used this new downstream process at the predicted manufacturing scale to generate clinical quality drug substance for multiple monoclonal antibodies. With the success of the new integrated system, our team is shifting its focus to implementation on a clinical program. A key element of the ongoing work is to establish the control and robustness of novel elements of our process such as confirming that the critical pH has been achieved during cVI and demonstrating robust impurity removal for dynamic loading on an AEX polishing step. In this talk, we will explain our approach to integrated continuous downstream processing and our strategy for future implementation. Data from at-scale demonstration runs will show the robustness of the process over a wide range of loading conditions. This will include product quality data including HCP, DNA, charge variants and aggregate removal that is consistent with batch processes. Process data will show the control and robustness of the approach

CP violating asymmetry in H±→W±h1H^\pm\to W^\pm h_1 decays

The CP violating asymmetry from the decay rates $H^\pm\to W^\pm h_1$ of charged Higgs bosons into the lightest neutral Higgs boson and a $W^\pm$ boson is calculated and discussed in the complex MSSM. The contributions from all complex phases are considered, especially from the top-squark trilinear coupling, which induces a large contribution to the CP asymmetry.Comment: 19 pages, 10 figures, version published in JHE

Enabling technologies for integrated / continuous downstream processing of biologics

Pfizer Bioprocessing R&D is focused on developing enabling technologies that will reduce capital and operational expenses, decrease equipment scale, increase automation and utilize fewer FTEs. To realize this vision, Purification Process Development has piloted new technologies and operational strategies that have enabled a fully integrated downstream process. Our current work has demonstrated a continuous process that includes tangential flow filtration harvest from a perfusion bioreactor, Protein A capture, inline viral inactivation/conditioning and AEX polishing. This process was fully automated and demonstrated at the 100 L scale. We have also shown feasibility of multi-day virus reduction filter operation and a continuous ultrafiltration/diafiltration using counter-current single-pass tangential flow filtration. These technologies and strategies are critical elements of our long term goal of establishing a fully integrated process from bioreactor to drug substance. With this process, we hope to remove product supply as a critical path activity for both toxicology and clinical needs

Radiative Corrections to W^+W^- \to W^+W^- in the Electroweak Standard Model

The cross-section for W^+W^- \to W^+W^- with arbitrarily polarized W bosons is calculated within the Electroweak Standard Model including the complete virtual and soft-photonic O(alpha) corrections. We show the numerical importance of the radiative corrections for the dominating polarized cross-sections and for the unpolarized cross-section. The numerical accuracy of the equivalence theorem is investigated in O(alpha) by comparing the cross-section for purely longitudinal W bosons obtained from the equivalence theorem and from the direct calculation. We point out that the instability of the W boson, which is inherent in the one-loop corrections, prevents a consistent calculation of radiative corrections to the scattering of on-real-mass-shell longitudinal W bosons beyond O(alpha).Comment: 24 pages, LaTeX, uses axodraw, epsfig. Statement clarifie