Формирование вейвлет-функций в задаче идентификации музыкальных сигналов

Предложен подход, позволяющий формировать вейвлет-функции на основе периодических сигналов и фрагментов сигналов музыкальных инструментов. Рассмотрены необходимые и достаточные условия, предъявляемые к формируемым вейвлет-функциям. Описан эксперимент, позволяющий идентифицировать несколько гармонических составляющих сигнала, локализованных во времени. Показана возможность применения разработанного подхода в задачах идентификации сложных музыкальных сигналов

Bile salt export pump-reactive antibodies form a polyclonal, multi-inhibitory response in antibody-induced bile salt export pump deficiency

Funding Information: Expert technical assistance by Paulina Philippski, Nicole Eichhorst, Annette Tries, and Nathalie Walter is gratefully acknowledged. The authors thank “Hamburg macht Kinder gesund” and the “YAEL-Stiftung” for supporting the database on liver-transplanted children at the University Medical Center Hamburg-Eppendorf. Finally, the authors gratefully acknowledge Robin Marceca (founder of pfic.org) for her outstanding support throughout this study. Funding Information: Expert technical assistance by Paulina Philippski, Nicole Eichhorst, Annette Tries, and Nathalie Walter is gratefully acknowledged. The authors thank ?Hamburg macht Kinder gesund? and the ?YAEL-Stiftung? for supporting the database on liver-transplanted children at the University Medical Center Hamburg-Eppendorf. Finally, the authors gratefully acknowledge Robin Marceca (founder of pfic.org) for her outstanding support throughout this study. Publisher Copyright: © 2016 by the American Association for the Study of Liver Diseases.Progressive familial intrahepatic cholestasis type 2 (PFIC-2) is caused by mutations in ABCB11, encoding the bile salt export pump (BSEP). In 2009, we described a child with PFIC-2 who developed PFIC-like symptoms after orthotopic liver transplantation (OLT). BSEP-reactive antibodies were demonstrated to account for disease recurrence. Here, we characterize the nature of this antibody response in 7 more patients with antibody-induced BSEP deficiency (AIBD). Gene sequencing and immunostaining of native liver biopsies indicated absent or strongly reduced BSEP expression in all 7 PFIC-2 patients who suffered from phenotypic disease recurrence post-OLT. Immunofluorescence, western blotting analysis, and transepithelial transport assays demonstrated immunoglobulin (Ig) G-class BSEP-reactive antibodies in these patients. In all cases, the N-terminal half of BSEP was recognized, with reaction against its first extracellular loop (ECL1) in six sera. In five, antibodies reactive against the C-terminal half also were found. Only the sera recognizing ECL1 showed inhibition of transepithelial taurocholate transport. In a vesicle-based functional assay, transport inhibition by anti-BSEP antibodies binding from the cytosolic side was functionally proven as well. Within 2 hours of perfusion with antibodies purified from 1 patient, rat liver showed canalicular IgG staining that was absent after perfusion with control IgG. Conclusions: PFIC-2 patients carrying severe BSEP mutations are at risk of developing BSEP antibodies post-OLT. The antibody response is polyclonal, targeting both extra- and intracellular BSEP domains. ECL1, a unique domain of BSEP, likely is a critical target involved in transport inhibition as demonstrated in several patients with AIBD manifest as cholestasis.publishersversionPeer reviewe

Sustainability trade-offs in Climate Change Geographies in England

©2024 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/The evidence that climate change is the result of human actions becomes yet stronger, as does the need to take action to limit the worst effects of climate change on the planet. However, politicians continue to equivocate and fail to address the trade-offs which are needed to deliver effective action. In this paper we report on the potential of bottom-up approaches to transport planning to address the trade-offs between the need to reduce car-based travel and the social consequences of poor mobility options in rural areas. Using theories of Sustainable Communities and Communi-ties of Practices, we analyze the implementation of the Robin Demand Responsive Transport service in the West of England, presenting new data relating to the effectiveness of this service in providing low carbon transport alternatives to rural residents. We find that the Robin is indeed effective, and that it has worked better in one location, where engagement with potential new users of the service has been prioritized. We conclude that such bottom-up transport options can be transformative, subject to the support of key stakeholders and integration with top-down systems of governance.Peer reviewe

Entwicklungspädagogische Initiative in Ostdeutschland. Unterrichtshilfe per Fernleihe

Das Entwicklungspädagogische Informationszentrum "We are the world" an der Dr.-Albert-Schweizer Schule Vetschau (Land Brandenburg) ist ein Projekt von Schülern und Lehrern zur Förderung des entwicklungspolitischen Unterrichts und des "Eine-Welt-Gedankens" in der heutigen Zeit. Dabei sollen Formen der echten Solidarität und des Aufeinanderzugehens Inhalt der Arbeit sein. (DIPF/Orig.

Angst, Depressivität und gesundheitsbezogene Lebensqualität nach akuter zerebraler Ischämie - ein prospektiver longitudinaler Vergleich zwischen Patienten mit Hirninfarkt und transitorisch ischämischer Attacke

Vergleichende Langzeitbeobachtung (1 Jahr) von Angst, Depressivität und gesundheitsbezogener Lebensqualität nach Hirninfarkt oder transitorisch ischämischer Attacke im Versorgungsgebiet der A. cerebri media

Intrahepatic type II gall bladder perforation by a gall stone in a CAPD patient

<p>Abstract</p> <p>Introduction</p> <p>Perforation of the gall bladder represents a rare, but life-threatening complication of cholecystitis. Clinical presentation may vary between severe peritonism in acute perforation and absence of symptoms in subacute or chronic progression of perforation. Abdominal imaging like ultrasound or CT-scan are important tools for immediate diagnose of gall bladder perforation.</p> <p>Case presentation</p> <p>We report a case of a 30-year old female patient with end-stage kidney disease treated by continuous ambulatory peritoneal dialysis (CAPD) who was admitted to the emergency room with fever and mild abdominal pain. A type II gall bladder perforation by a solitary gall stone with development of a liver abscess was detected by abdominal ultrasound.</p> <p>Conclusion</p> <p>Gall bladder perforations are rare but have to be considered in patients with abdominal pain and fever. Abdominal ultrasound is a reliable tool to establish diagnosis.</p

Perceptions of Global and Domestic Agricultural Issues Held by International Agricultural Journalists

The purpose of this study was to provide baseline knowledge of the prevalent global and domestic agricultural issues, ways to educate journalists about these issues, and sources of information used when reporting about agricultural issues, according to international agricultural journalists. The executives of the International Federation of Agricultural Journalists served as this study’s population. The IFAJ is comprised of a membership of 31 countries that practice freedom of the press. A modified Delphi method with three rounds of data collection was utilized for this study. Qualitative feedback was provided by the executives in Round One. In Rounds Two and Three, quantitative feedback was used with the goal of forming consensus on the most important global issues and methods to educate journalists about these issues.A list of important domestic agricultural issues was supplied for 20 countries. The executives also generated a list of important global agricultural issues and ways to educate journalists about these issues. Important global agricultural issues included feeding a growing global population and water quality/quantity. Face-to-face methods of educating journalists were favored by the executives. The executives identified a wide variety of sources they use to report about global and domestic agricultural issues, including government agencies, farmers, universities, online sources, professional organizations, commodity group websites, and academic journals

Zelluläre Abstoßungen herztransplantierter Patienten in Münster

Wir untersuchten in dieser Studie retrospektiv die Daten von 246 Patienten, die zwischen 1990 und 2003 in Münster herztransplantiert wurden, hinsichtlich Häufigkeit und Folgen von zellulären Abstoßungen. Die Wahrscheinlichkeit, am Ende des ersten Jahres keine Abstoßung erlitten zu haben, lag bei 60%. Jüngere Patienten und Patienten mit anderen Grunderkrankungsgruppen zur Herztransplantation als KHK und DCM hatten ein signifikant höheres Risiko. Patienten mit Abstoßungen hatten ein höheres Risiko zu versterben und eine schlechtere Transplantatfunktion, die zu dem geringeren Überleben beitrug. Wir untersuchten des Weiteren mit Hilfe der multivariaten Analyse den klinischen Nutzen der Verwendung der Echokardiographie zur Diagnostik einer kardialen Abstoßung. Keines der geprüften Modelle zeigte eine ausreichende Sensitivität und Spezifität. Die Echokardiographie kann nach diesen Ergebnissen die Endomyokardbiopsie zur Diagnose von Abstoßung nicht ersetzten

A designstudy for Springfield Armory, Springfield, Massachusetts

Thesis (M.Arch.) Massachusetts Institute of Technology. Dept. of Architecture, 1956.by Frederick T. Kubitz.M.Arch

Gemischte Least-Squares-FEM für Elastoplastizität

[no abstract