The effect of the addition of nanotubes upon the thermo-protective properties of the aramid-reinforced composite

The aim of this article is to present findings concerning the thermo-protective research into ablative materials. The authors analysed the impact of the addition of carbon nanotubes upon the selected ablation properties, i.e. the ablation mass waste, average linear rate of ablation and the backside temperature of the specimens. The performed tests as well as the obtained findings allowed formulating a number of conclusions, which are useful in creating future composites. Composition of individual test samples; ablation testing; average relative ablation mass loss, depending on the volume share of carbon nanotubes; average ablation rate, depending on the volume share of carbon nanotubes; temperature of the rear surface of the insulating sample, depending on the volume share of carbon nanotubes; temperature inside the composite, depending on the volume share of carbon nanotubes; comparison of the temperature of ablation surface, temperature inside the composite and temperature on the rear surface of the wall of carbon nanotubes after the exposition to a heat flux are presented in the article

Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots ofPerovskia atriplicifoliaBenth.

Inhibition of cholinesterases remains one of a few available treatment strategies for neurodegenerative dementias such as Alzheimer's disease and related conditions. The current study was inspired by previous data on anticholinesterase properties of diterpenoids fromPerovskia atriplicifoliaand other Lamiaceae species. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition by the three new natural compounds-(1R,15R)-1-acetoxycryptotanshinone (1), (1R)-1-acetoxytanshinone IIA (2), and (15R)-1-oxoaegyptinone A (3)-as well as, new for this genus, isograndifoliol (4) were assessed. Three of these compounds exhibited profound inhibition of butyrylcholinesterase (BChE) and much weaker inhibition of acetylcholinesterase (AChE). All compounds (1-4) selectively inhibited BChE (IC50= 2.4, 7.9, 50.8, and 0.9 mu M, respectively), whereas only compounds3and4moderately inhibited AChE (IC(50)329.8 mu M and 342.9 mu M). Molecular docking and in silico toxicology prediction studies were also performed on the active compounds. Natural oxygenated norditerpenoids from the traditional Central Asian medicinal plantP. atriplicifoliaare selective BChE inhibitors. Their high potential makes them useful candidate molecules for further investigation as lead compounds in the development of a natural drug against dementia caused by neurodegenerative diseases

Recursive local polynomial regression under dependence conditions

Local polynomial fitting, recursive nonparametric estimation, strongly mixing processes, 62G07, 62H12, 62M09,