Can chaotic quantum energy levels statistics be characterized using information geometry and inference methods?

In this paper, we review our novel information geometrodynamical approach to chaos (IGAC) on curved statistical manifolds and we emphasize the usefulness of our information-geometrodynamical entropy (IGE) as an indicator of chaoticity in a simple application. Furthermore, knowing that integrable and chaotic quantum antiferromagnetic Ising chains are characterized by asymptotic logarithmic and linear growths of their operator space entanglement entropies, respectively, we apply our IGAC to present an alternative characterization of such systems. Remarkably, we show that in the former case the IGE exhibits asymptotic logarithmic growth while in the latter case the IGE exhibits asymptotic linear growth. At this stage of its development, IGAC remains an ambitious unifying information-geometric theoretical construct for the study of chaotic dynamics with several unsolved problems. However, based on our recent findings, we believe it could provide an interesting, innovative and potentially powerful way to study and understand the very important and challenging problems of classical and quantum chaos.Comment: 21 page

Nucleosomes in gene regulation: theoretical approaches

This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangements in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from molecular-mechanistic and biological point of view. In addition to classical problems of this field, actual questions of epigenetic regulation are discussed. The authors selected for discussion what seem to be the most interesting concepts and hypotheses. Mathematical approaches are described in a simplified language to attract attention to the most important directions of this field

Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET

The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR

Relationship of edge localized mode burst times with divertor flux loop signal phase in JET

A phase relationship is identified between sequential edge localized modes (ELMs) occurrence times in a set of H-mode tokamak plasmas to the voltage measured in full flux azimuthal loops in the divertor region. We focus on plasmas in the Joint European Torus where a steady H-mode is sustained over several seconds, during which ELMs are observed in the Be II emission at the divertor. The ELMs analysed arise from intrinsic ELMing, in that there is no deliberate intent to control the ELMing process by external means. We use ELM timings derived from the Be II signal to perform direct time domain analysis of the full flux loop VLD2 and VLD3 signals, which provide a high cadence global measurement proportional to the voltage induced by changes in poloidal magnetic flux. Specifically, we examine how the time interval between pairs of successive ELMs is linked to the time-evolving phase of the full flux loop signals. Each ELM produces a clear early pulse in the full flux loop signals, whose peak time is used to condition our analysis. The arrival time of the following ELM, relative to this pulse, is found to fall into one of two categories: (i) prompt ELMs, which are directly paced by the initial response seen in the flux loop signals; and (ii) all other ELMs, which occur after the initial response of the full flux loop signals has decayed in amplitude. The times at which ELMs in category (ii) occur, relative to the first ELM of the pair, are clustered at times when the instantaneous phase of the full flux loop signal is close to its value at the time of the first ELM

МЕТОД ЛОКАЛЬНОГО ФИБРИНОЛИЗА В ХИРУРГИИ НЕТРАВМАТИЧЕСКИХ ВНУТРИЧЕРЕПНЫХ КРОВОИЗЛИЯНИЙ

More than 70% of hypertensive hemorrhages are located in deep brain structures. The removal of such hematomas using encephalotomy is accompanied by additional cerebral trauma and often results in unsatisfactory outcomes. The puncture aspiration with local fibrinolysis is one of the minimal invasive methods for treatment of intracerebral hematomas (ICH). The puncture and aspiration of liquid part of ICH (not more than 20% of ICH volume) is performed via small burr hole. Afterward the catheter is placed into ICH cavity and fibrinolytic is injected via this catheter in postoperative period for lysis of ICH solid part. The lysed blood is aspirated within 1-4 days. The last generations of fibrinolytics are very effective concerning intensity of blood clot lysis and practically have no systematic effect on blood coagulation system during their local usage. Morphological examinations showed that usage of fibrinolysis leads to formation of smaller cysts in the region of former hematoma as well as reparative processes in perihemorrhagical zone are expressed better comparing with treatment methods without usage of fibrinolytics. The morphological pattern is also confirmed by clinical signs of neurological deficit regress corresponding to damage focus. We operated 124 patients with parenchymal hemorrhages and 28 patients with intraventricular hemorrhages using described minimally invasive method at the base of Scientific Research Institute of Emergency Care n.a. N.V. Sklifosovsky. The applied method allowed decreasing lethality from 35% to 21% among patients with parenchymal ICH and from 98% to 48% - among patients with ventricular hemotamponade underwent usage of ventricular drainage combined with local fibrinolysis.   Более 70% гипертензивных кровоизлияний располагаются в глубинных отделах головного мозга. Удаление этих гематом путем энцефалотомии сопровождается дополнительной травматизацией мозга, и часто неудовлетворительными результатами. Одним из малотравматичных методов эвакуации внутримозговых гематом (ВМГ) является пункционная аспирация и локальный фибринолиз. Через небольшое трепанационное отверстие ВМГ пунктируют и аспирируют жидкую часть, которая составляет не более 20%. В полости гематомы оставляют катетер, через который в послеоперационном периоде вводят фибринолитик, растворяющий плотную часть гематомы. Лизированную кровь аспирируют в течение 1-4 суток. Последние поколения фибринолитиков очень эффективны в плане интенсивности растворения сгустка крови и практически не обладают системным воздействием на свертывающую систему крови при локальном применении. Морфологические исследования показали, что при использовании фибринолиза в области бывшей гематомы формируется киста меньшего размера, а репаративные процессы в зоне, окружающей гематому, выражены лучше, чем в случаях лечения без использования фибринолитиков. Морфологическая картина соответствует и клиническим данным о регрессе неврологической симптоматики, соответствующей очагу поражения. В институте скорой помощи им. Н.В. Склифосовского прооперированы 124 пациента с паренхиматозными кровоизлияниями и 28 – с вентрикулярными. Метод позволил снизить летальность с 35 до 21%  при паренхиматозных ВМГ и с 98 до 48%  при сочетании дренирования желудочков с локальным фибринолизом у больных с вентрикулярной гемотампонадой. 

PSMA-Targeted Radiopharmaceuticals for Imaging and Therapy of Prostate Cancer

Abstract Molecular changes in prostate cancer lead to increased expression of prostate-specific membrane antigen (PSMA), which is a suitable target for imaging and therapy using radiopharmaceuticals. Data on the most effective clinically significant PSMA radiopharmaceuticals for the diagnosis and treatment of prostate cancer are summarized. The advantages and disadvantages of ligands based on monoclonal antibodies and their fragments as well as small molecular PSMA inhibitors are discussed