Complex treatment of accommodation disturbances in students

Purpose: Assessment of the effectiveness of different methods of treatment accommodation disturbances in patients 18‑23 years old.Methods: Determination of refraction and the size of the absolute accommodation and reserves of the relative accommodationbefore and after the treatment with Midrimax and Irifrin 2.5 % in combination with the course of electrostimulation.Results: The clinical effect was obtained in all patients. The maximum improvement of visual functions with a lower degree of myopia (1.0‑3.0 D), increase of absolute accommodation (by 2.5‑3,.D) and reserves of the relative accommodation (up to age norms) were observed in the younger age group of patients, wich had received the treatment with Midrimax, especially when combined with electrostimulation.Conclusion: Instillation of Midrimax in the treatment of violations of accommodation contribute to the effective reduction in the degree of myopia and improve of accomodation in patients 18‑23 years old. The combination of this therapy with functional methods of treatment increase its effectiveness.</p

Dialectics of Public and Private in the Texts of M. Malinovskaya and G. Rymbu

Благодарности: Саморуковой Ирине Владимировне, доктору филологических наук, профессору.Acknowledgments: Samorukova Irina, Holder of an Advanced Doctorate (Doctor of Science) in Philological Sciences, Full Professor.Работа посвящена рассмотрению сфер публичного и приватного в современной поэзии через призму гендерного проявления личности. Анализируется ф-письмо, провозглашающее частное публичным, репрезентирующее наиболее острые вопросы современного общества и стремящееся к преодолению устаревших рамок письма.The work is dedicated to the review of the spheres of public and private in modern poetry through the prism of gender manifestation of personality. The article analyzes the f-writing proclaiming the private as public, representing the most important issues of modern society and striving to overcome the outdated framework of writing

ОЦЕНКА ПОКАЗАТЕЛЕЙ АНТИОКСИДАНТНОЙ И ГЛУТАТИОНОВЫХ СИСТЕМ В КРОВИ зДОРОВЫХ ЛЮДЕЙ

Oxygen is necessary element for the life of most living organisms. Most part of the oxygen consumed by the human body is used in energy generation processes, but about 2–5% metamorphose to reactive oxygen species (ROS), which can exhibit a pronounced toxic effect on cells, initiating oxidative modification of lipids and proteins. Protection of cells, organs and the whole body from ROS, in General, is carried out by the antioxidant system (AOS), the most important components of which is glutathione and enzymes of its metabolism.Кислород необходим для жизнедеятельности большинства живых организмов. Большая часть потребляемого организмом человека кислорода используется в процессах генерирования энергии, но около 2–5% переходит в активные формы кислорода (АФК), которые могут проявлять выраженное токсическое действие на клетки, инициируя окислительную модификация липидов и белков. Защита клеток, органов и всего организма от АФК, в целом, осуществляется антиоксидантной системой (АОС), важнейшими компонентами которой служит глутатион и ферменты его метаболизма

Modern state of irrigated soils at the south of the Volga upland

The goal is to assess the impact of 50-year irrigation by sprinkling on soil processes occurring in the light-chestnut soils (Luvic Kastanozem (Loamic, Aric, Protosodic, Bathysalic)) of the southern slopes of the Volga upland at the Volga-Don interfluve (FSUE “Oroshaemoe”, the Volgograd region) with deep ground water. Water for irrigation is supplied from the Varvarovsky reservoir of the Volga-Don Canal system. It is characterized by a total dissolved salts of about 1 g/l, a bicarbonate-chloride-sulfate compositionwith an increased sodium content. Detailed morphological description of soil profiles, granulometric composition, content of soluble salts in soils and sediments of the vadoze zone up to the depth of 3.5 m, dynamics of salts in the layer of 0-50 cm for 2011-2019 are presented. Until the autumn of 2015, the studied soils were deep saline, being no saline in the layer of 0-100 cm. In recent years, a weak salinity degree of soda-chloride sodium chemistry has been observed in the 0-50 cm layer as a result of gradual accumulation of irrigation water salts during irrigation organized according to water consumption of agricultural crops. Irrigated soils have acquired a complex of signs of secondary salinity: (1) the presence of light accumulations of sandy and silt mineral grains in the arable horizon, resulting from the destructive effect of irrigation water drops during sprinkling; (2) toxic alkalinity associated with sodium (residual sodium carbonate), according to water extraction 1 : 5 (soil : water), in the horizons from the depth of 10-20 to 60100 cm; (3) abundant humus-clay cutans on the lateral side faces of prismatic structural units in the undisturbed part of the soil profile from 30 to 100 cm

Использование публичных данных в судебных экспертизах по определению стоимости объектов недвижимости: проблемы, ограничения, возможности

One of the problems with the practice of legal proceedings is the determination of the legal authority limits of a forensic expert when he forms an array of initial data, the structure and content of which would provide a full and comprehensive research of the issues put before him by the body (person) having appointed the examination. The possibility of the specifed initial data completeness ensuring is suggested and substantiated in the article, arguments arising from the provisions of the law concerning neutralization of the traditional criticism directions of the expert in this part during his interrogation in the course of judicial proceedings on his conclusion are adduced.Одна из проблем судопроизводства – определение пределов правомочий судебного эксперта при формировании им массива исходных данных, структура и содержание которого обеспечивала бы полное и всестороннее исследование по вопросам, поставленным перед ним органом (лицом), назначившим экспертизу. В статье предложена и обоснована возможность обеспечения полноты указанных исходных данных, приведены вытекающие из положений закона аргументы относительно нейтрализации традиционных направлений критики эксперта в этой части при его допросе в ходе судебного заседания по данному им заключению

Nestin-expressing cell types in the temporal lobe and hippocampus: Morphology, differentiation, and proliferative capacity

Nestin is expressed in immature neuroepithelial and progenitor cell types and transiently upregulated in proliferative neuroglial cells responding to acute brain injury, including following seizures. In 36 temporal lobe specimens from patients with temporal lobe epilepsy (age range 8-60 years) we studied the number, distribution and morphology of nestin-expressing cells in the pes, hippocampus body, parahippocampal gyrus, amygdala, temporal cortex and pole compared to post mortem control tissues from 26 cases (age range 12 gestational weeks to 76 years). The proliferative fraction of nestin-expressing cells was also evaluated in selected regions, including recognized niches, using MCM2. Their differentiation was explored with neuronal (DCX, mushashi, βIII tubulin, NeuN) and glial (GFAP, GFAPdelta, glutamine synthetase , aquaporin4) markers, both in sections and following culture. Findings were correlated with clinical parameters. A stereotypical pattern in the distribution and range of morphologies of nestin-expressing cells was observed, reminiscent of patterns in the developing brain, with increased densities in epilepsy compared to adult controls (p<0.001). Findings included MCM2-positive radial glial-like cells in the periventricular white matter and rows of nestin-expressing cells in the hippocampal fimbria and sulcus. Nestin cells represented 29% of the hippocampal proliferative fraction in epilepsy cases; 20% co-expressed βIII tubulin in culture compared to 28% with GFAP, but they mainly lacked glial maturation (aquaporin 4 or glutamine synthetase expression). Significant correlations were noted between age at surgery, memory deficits and NEC populations. Temporal lobe nestin-expressing cells with ongoing proliferative capacity likely represent vestiges of developmental migratory streams and resident reactive cell populations of potential relevance to hippocampal epileptogenesis, temporal lobe pathology and co-morbidities, including memory decline

МЕТОДОЛОГИЧЕСКИЙ ПОДХОД К ПЛАНИРОВАНИЮ ЭКСПЕРИМЕНТА ПРИ ВЫБОРЕ КАЧЕСТВЕННЫХ РЕАКЦИЙ ДЛЯ ПОДТВЕРЖДЕНИЯ ПОДЛИННОСТИ КОМПОНЕНТОВ ЛЕКАРСТВЕННОГО СРЕДСТВА (НА ПРИМЕРЕ АСКОРБИНОВОЙ КИСЛОТЫ)

The need for identification  testing of active substances or excipients in multi-component medicinal products,  including the use of qualitative tests, calls for research substantiating the choice of tests and test conditions  with due regard to interference  effects caused by other components  of medicinal products and the amount of the sample used. The aim of the study was to develop a methodological approach to designing experiments while selecting qualitative reactions for identification testing of a medicinal product component based on the results of studies investigating the possibility of using known qualitative tests (as illustrated by ascorbic acid in a multi-component product — 0.4 mg of ascorbic acid per 100 mg of the vial contents)  with due regard to interference on the part of other medicinal product components and the amount of the sample used. Material and methods: the study focused on a multi-component medicinal product — lyophilisate for solution for intravenous and intramuscular  injections containing an antiinflammatory active substance and ascorbic acid as a stabilizing agent (antioxidant). The analysis of literature sources helped to determine qualitative tests that were assessed for potential use for identification testing of ascorbic acid as a component of the analysed medicinal product. The study involved experimental testing of the qualitative reactions based on acidic and reducing properties of ascorbic acid. Results: it was demonstrated that several well-known qualitative tests could be used for identification  testing of ascorbic acid as a component of the analysed medicinal product,  namely, the reaction of ferrous ascorbate formation  and the reaction of silver nitrate reduction to metallic silver after preliminary separation of ascorbic acid from the other medicinal product components, as well as the reaction of Prussian blue formation,  iodine test and reaction with a potassium permanganate solution, which do not require additional sample preparation.  It is not practicable to use the reaction with a methylene blue solution and the Fehling’s reagent reaction for this particular medicinal product,  since their results are feeble. Conclusions: the analysis of the multi-component medicinal product helped to develop a methodological  approach to choosing qualitative reactions for identification testing of one of the medicinal product’s components  (e.g., ascorbic acid). The suggested algorithm includes the choice of reactions, determination of their sensitivity and applicability for a particular medicinal product, analysis of the other components’ effects on the results of the chemical reaction,  and the need for additional sample preparation.  The whole complex of the studies performed helped to determine qualitative reactions and optimal conditions for identification testing of the analysed substance.Необходимость подтверждения подлинности  действующих  или  вспомогательных веществ  многокомпонентных лекарственных средств,  в том числе с использованием качественных  реакций, влечет за собой  необходимость  проведения исследований по выбору реакций  и условий их проведения с учетом мешающего  влияния других компонентов лекарственного средства  и количества  используемого образца.  Цель работы: разработка  методологического подхода к планированию эксперимента при выборе  качественных  реакций  для подтверждения подлинности определяемого компонента лекарственного средства на основании результатов исследований возможности использования известных качественных  реакций  (на примере  аскорбиновой кислоты  в многокомпонентном лекарственном средстве — 0,4 мг аскорбиновой кислоты / 100 мг содержимого  флакона) с учетом мешающего влияния других компонентов лекарственного средства и количества  используемого образца.  Материалы и методы: в качестве  объекта исследования было выбрано  многокомпонентное лекарственное средство  — лиофилизат для приготовления раствора  для внутривенного и внутримышечного введения  с лекарственным веществом,  обладающим  противовоспалительным действием,  в состав которого  входит аскорбиновая кислота  в качестве  стабилизатора (антиоксиданта). В результате анализа  данных литературы  выбраны  качественные реакции  для проведения исследований возможности их использования для подтверждения  подлинности аскорбиновой кислоты  в изучаемом  лекарственном средстве.  Проведена  экспериментальная проверка  реакций, основанных на кислотных  и восстановительных свойствах аскорбиновой кислоты.  Результаты: установлено, что в изучаемом многокомпонентном лекарственном средстве для подтверждения подлинности аскорбиновой кислоты могут быть применимы несколько известных качественных реакций: реакции образования аскорбината железа и восстановления нитрата серебра до металлического серебра после предварительного отделения аскорбиновой кислоты  от других компонентов лекарственного средства,  а также реакция  образования берлинской лазури,  йодная проба и реакция  с раствором  перманганата калия,  не требующие  дополнительной пробоподготовки. Использование реакций  с раствором  метиленового  синего и реактивом  Фелинга  применительно к данному лекарственному средству нецелесообразно, так как результат указанных реакций  слабо выражен. Выводы: на примере многокомпонентного лекарственного средства разработан  методологический подход к выбору качественных  реакций  для подтверждения подлинности одного  из компонентов лекарственного средства  (например, аскорбиновой кислоты).  Алгоритм действий включает в себя выбор реакций, определение их чувствительности и целесообразности применения для конкретного лекарственного средства,  изучение  влияния других его компонентов на результат химической реакции, а также необходимость  или отсутствие дополнительной пробоподготовки. Совокупность проведенных  исследований позволяет сделать выбор качественных  реакций  и оптимальных  условий  их проведения для достижения поставленной цели — подтверждения подлинности определяемого вещества

Bioaerosol Release from Concentrated Microbial Suspensions in Bubbling Processes

Bursting bubbles are one of the most common mechanisms in aerosols&rsquo; formation from natural and artificial waterbodies. The presence of microbial materials in the liquid could cause their aerosolization and generation of bioaerosols. The process depends on a number of parameters of the gas and liquid involved. This project investigated the influence of the air flow, bubble size, the temperature of the liquid and its surface tension on the efficiency of bioaerosol generation. It was found that the bioaerosol is more efficiently produced at higher air flow rates and smaller bubble size. The influence of the liquid temperature was also identified to be quite high, reaching an order of magnitude of the bioaerosol concentration over the temperature range from 4 &deg;C to 38 &deg;C. The addition of surfactants did suppress the foam formation, which was found to have a negative effect on the process; the rate of the bioaerosol generation increased with the increase in the antifoam concentration