Change in sports activity and walking and cycling for transport since the COVID-19 pandemic – Results of the GEDA 2021 study

Background: Physical activity is a significant health promotion behaviour. COVID-19 pandemic mitigation measures, such as reducing social contact, closing sports facilities and working from home offices, may make it more difficult to engage in regular physical activity. Methods: The data collected between July and October 2021 from the nationally representative study German Health Update (GEDA 2021) were used. The activity behaviour is described by the change in the amount of sports activity as well as the amount of physical active transport (walking/cycling) since the beginning of the COVID-19 pandemic. The sample comprises 2,985 participants aged 18 and older. Results: A quarter of the population reduced their sports activity compared to before the COVID-19 pandemic, while 12% increased their sports activity and 38% reported no change. In terms of physical active transport, it shows that 15% reduced the amount, 17% increased it and 55% maintained it. Compared to younger adults, older adults were more likely to maintain their activity behaviour rather than reduce or increase it. Conclusion: Even before the pandemic, physical inactivity was common among the population. The high proportion of adults who reduced their sports activity during the pandemic underlines the need for effective measures to promote physical activity

Determinants of organised sports participation patterns during the transition from childhood to adolescence in Germany: results of a nationwide cohort study

Abstract Background Organised sports (OS) participation is an important health behaviour but it seems to decline from childhood to adolescence. The aim of this study was to investigate OS participation patterns from childhood to adolescence and potential determinants for those patterns. Methods Data from the German Health Interview and Examination Survey for Children and Adolescents (KiGGS) cohort study with a 6 year follow-up period were used (KiGGS0: 2003-06, KiGGS1: 2009-12). Participants aged 6–10 years at KiGGS0, who were aged 12–16 at KiGGS1, were included (n = 3790). The outcome variable was ‘OS participation’ between KiGGS0 and KiGGS1 with the categories ‘maintenance’ (reference), ‘dropout’, ‘commencement’ and ‘nonparticipation’. Relative risk ratios (RRRs) were calculated using multinomial logistic regression to identify potential predictors for OS patterns. Socio-demographic, family-related, health-related, behavioural and environmental factors were considered as independent variables. Results 48.5 % maintained OS, 20.5 % dropped out, 12.3 % commenced OS between KiGGS0 and KiGGS1 and 18.7 % did not participate at both times. The RRRs for dropout rather than maintenance were 0.6 (95 % Cl 0.5–0.7) for boys versus girls, 1.5 (1.3–1.9) for the age group 8–10 versus 6–7 years, 0.7 (0.5–0.9) for high versus intermediate parental education, 1.4 (1.1–1.8) for low versus middle household income, 1.4 (1.0–1.8) for below-average versus average motor fitness. The RRRs for commencement rather than maintenance were 0.6 (0.5–0.8) for boys versus girls, 0.6 (0.5–0.8) for the age group 8–10 versus 6–7 years, 1.5 (1.1–2.1) for low versus intermediate parental education, 1.5 (1.1–2.0) for low versus middle household income, 0.7 (0.5–1.0) for no single-parent versus single parent family, 1.8 (1.3–2.5) for below-average and 0.6 (0.4–0.8) for above-average versus average motor fitness, and 1.4 (1.1–1.9) for high versus middle screen-based media use. The RRRs for abstinence rather than maintenance were 0.6 (0.4–0.7) for boys versus girls, 1.5 (1.1–2.0) for low versus intermediate parental education, 2.2 (1.7–2.8) for low and 0.6 (0.5–0.8) for high versus middle household income, 1.6 (1.2–2.1) for psychopathological problems versus no problems, 1.7 (1.3–2.2) for below-average and 0.4 (0.3–0.6) for above-average versus average motor fitness, and 1.6 (1.0–2.6) for rural versus metropolitan residential area. Conclusions OS participation rates among all children living in Germany need to be improved. More tailored offerings are needed which consider the preferences and interests of adolescents as well as a cooperation between public health actors to reduce barriers to OS

How much do adults sit? Result from the German Health Update (GEDA 2019/2020-EHIS)

Background: Sedentary behaviour is increasingly perceived as a risk factor for the development of diseases and for increased mortality. In particular, increased time spent sitting in combination with low physical activity seems to have negative health consequences. Methods: In the nationwide cross-sectional study German Health Update (GEDA 2019/2020-EHIS), the indicator ‘sitting’ was captured by the self-report of the participants. Results: For at least eight hours a day, 16.7% of women and 22.3% of men sit: Men more often than women, younger persons more often than older persons and the proportion increases significantly from the low to the high education group. Similarly, about one fifth of adults in Germany sit for at least four hours a day and do not engage in physical activity in their leisure time. Conclusion: The results indicate that preventive measures are needed to reduce time spent sitting and increase physical activit

Veränderung des Sporttreibens und der aktiven Wegstrecken seit der COVID-19-Pandemie – Ergebnisse der Studie GEDA 2021

Hintergrund: Körperliche Aktivität ist ein bedeutendes Verhalten zur Gesundheitsförderung. Die Maßnahmen zur Eindämmung der COVID-19-Pandemie, wie beispielsweise die Reduktion sozialer Kontakte, die Schließung von Sportstätten sowie das Arbeiten im Homeoffice, können die Ausübung regelmäßiger körperlicher Aktivität erschweren. Methode: Es wurden die zwischen Juli und Oktober 2021 erhobenen Daten der bundesweit repräsentativen Befragungsstudie Gesundheit in Deutschland aktuell (GEDA 2021) genutzt. Beschrieben wird das Aktivitätsverhalten anhand der Veränderung des Umfangs des Sporttreibens sowie der aktiv zurückgelegten Wegstrecken (Gehen/Radfahren) seit Beginn der COVID- 19-Pandemie. Die Stichprobe umfasst 2.985 Personen ab 18 Jahren. Ergebnisse: Ein Viertel der Bevölkerung hat das Sporttreiben, im Vergleich zur Zeit vor der COVID-19-Pandemie, reduziert, während 12 % mehr Sport trieben und 38 % keine Veränderung berichteten. In Bezug auf das aktive Zurücklegen von Wegstrecken zeigt sich, dass 15 % den Umfang reduzierten, 17 % ihn steigerten und 55 % ihn beibehielten. Verglichen mit Jüngeren behielten ältere Personen ihr Aktivitätsverhalten eher bei anstatt es zu reduzieren oder zu steigern. Schlussfolgerung: Bereits vor der Pandemie war körperliche Inaktivität in der Bevölkerung verbreitet. Der hohe Anteil an Personen, der seine Sportaktivität in der Pandemie reduzierte, unterstreicht die Notwendigkeit effektiver Maßnahmen zur Bewegungsförderung

Angulin-1 (LSR) Affects Paracellular Water Transport, However Only in Tight Epithelial Cells

Water transport in epithelia occurs transcellularly (aquaporins) and paracellularly (claudin-2, claudin-15). Recently, we showed that downregulated tricellulin, a protein of the tricellular tight junction (tTJ, the site where three epithelial cells meet), increased transepithelial water flux. We now check the hypothesis that another tTJ-associated protein, angulin-1 (alias lipolysis-stimulated lipoprotein receptor, LSR) is a direct negative actuator of tTJ water permeability depending on the tightness of the epithelium. For this, a tight and an intermediate-tight epithelial cell line, MDCK C7 and HT-29/B6, were stably transfected with CRISPR/Cas9 and single-guide RNA targeting angulin-1 and morphologically and functionally characterized. Water flux induced by an osmotic gradient using 4-kDa dextran caused water flux to increase in angulin-1 KO clones in MDCK C7 cells, but not in HT-29/B6 cells. In addition, we found that water permeability in HT-29/B6 cells was not modified after either angulin-1 knockout or tricellulin knockdown, which may be related to the presence of other pathways, which reduce the impact of the tTJ pathway. In conclusion, modulation of the tTJ by knockout or knockdown of tTJ proteins affects ion and macromolecule permeability in tight and intermediate-tight epithelial cell lines, while the transepithelial water permeability was affected only in tight cell lines

Exercise and Carotid Properties in the Young–The KiGGS-2 Study

Background: Carotid intima-media thickness (cIMT) and stiffness (cS) are predictive markers of early vascular aging and atherosclerotic risk. This study assessed, whether exercise has protective effects on carotid structure and function or on vascular risk in the young. Methods: Volume and change of exercise (recreational and organized sports participation) of German adolescents and young adults was assessed within the prospective population-study KiGGS at KiGGS-Wave-1 (2009–2012) and KiGGS-Wave-2 (2014–2017) using standardized self-reporting questionnaires. CIMT and cS were measured by real-time B-mode ultrasound sequences with semi-automated edge-detection and automatic electrocardiogram-gated quality control in 2,893 participants (14–28 years, 49.6% female). A cumulative index for atherosclerotic risk (CV-R) included z-scores of mean arterial pressure, triglycerides, total/HDL-cholesterol-ratio, body mass index, and HbA1c. Results: At KiGGS-Wave-2 cross-sectional CV-R but not cS and cIMT was lower in all exercise-groups compared to “no exercise” (B = −0.73, 95%-CI = −1.26 to 0.19, p = 0.008). Longitudinal volume of exercise was negatively associated with CV-R (B = −0.37, 95%-CI = −0.74 to 0.00, p = 0.048) but not with cS and cIMT. Cross-sectional relative risk of elevated CV-R but not cS and cIMT was lower in all exercise-groups compared to “no exercise” (RR = 0.80, 95%-CI = 0.66 to 0.98, p = 0.033). High exercise volumes were associated with lower relative risk of elevated CV-R (RR = 0.80, 95%-CI = 0.65–0.97, p = 0.021) and cS in tendency but not with cIMT. Conclusions: Increased levels of exercise are associated with a better cardiovascular risk profile in young individuals, but not with cS and cIMT. Our study confirms previous recommendations on exercise in this age group without demonstrating a clear benefit on surrogate markers of vascular health.Peer Reviewe

N-Acetylcysteine prevents but does not reverse dexamethasone-induced hypertension

1. We have shown previously that N-acetylcysteine (NAC) prevents the increase in blood pressure induced by adrenocorticotropin treatment. The present study investigated the effect of NAC on dexamethasone (Dex)-induced hypertension. 2. Male Sprague-Dawle

Health-promoting behaviour among adults in Germany – Results from GEDA 2019/2020-EHIS

Health-promoting behaviours are important at any age to prevent diseases and to promote well-being. Using data from GEDA 2019/2020-EHIS, a Germany-wide, representative survey, this article describes how often the adult population in Germany reports certain types of health-promoting behaviour in their everyday lives. The behaviours considered are non-smoking, low-risk alcohol consumption, achievement of the World Health Organization’s (WHO) recommendations on aerobic physical activity, at least daily fruit and vegetable consumption, and maintaining a body weight within the normal range. This article describes the proportion of people who report these behaviours in their everyday lives by gender, age and education level, the number of health-promoting behaviours each person reports and the most common combinations in which they occur. Young adults between 18 and 29 years are most likely to achieve a health-promoting lifestyle. The proportion of people who report at least 150 minutes of physical activity per week and a normal body weight is lower in later adulthood than among 18- to 29-year-olds. The recommendation to eat fruit and vegetables daily is implemented least often of all five aspects of health behaviour under study. Finally, women are more likely to lead a health-promoting lifestyle than men.Health-promoting behaviours are important at any age to prevent diseases and to promote well-being. Using data from GEDA 2019/2020-EHIS, a Germany-wide, representative survey, this article describes how often the adult population in Germany reports certain types of health-promoting behaviour in their everyday lives. The behaviours considered are non-smoking, low-risk alcohol consumption, achievement of the World Health Organization’s (WHO) recommendations on aerobic physical activity, at least daily fruit and vegetable consumption, and maintaining a body weight within the normal range. This article describes the proportion of people who report these behaviours in their everyday lives by gender, age and education level, the number of health-promoting behaviours each person reports and the most common combinations in which they occur. Young adults between 18 and 29 years are most likely to achieve a health-promoting lifestyle. The proportion of people who report at least 150 minutes of physical activity per week and a normal body weight is lower in later adulthood than among 18- to 29-year-olds. The recommendation to eat fruit and vegetables daily is implemented least often of all five aspects of health behaviour under study. Finally, women are more likely to lead a health-promoting lifestyle than men.Peer Reviewe

Wie viel sitzen Erwachsene? Ergebnisse der Studie Gesundheit in Deutschland aktuell (GEDA 2019/2020-EHIS)

Hintergrund: Sitzendes Verhalten wird zunehmend als ein Risikofaktor für die Entstehung von Erkrankungen und für eine erhöhte Sterblichkeit wahrgenommen. Insbesondere erhöhte Sitzzeiten in Kombination mit geringer körperlicher Aktivität scheinen negative Gesundheitsfolgen zu haben. Methode: In der bundesweiten Querschnittstudie Gesundheit in Deutschland aktuell (GEDA 2019/2020-EHIS) wurde der Indikator „Sitzen“ durch die Selbstangabe der Teilnehmenden erfasst. Ergebnisse: Für mindestens acht Stunden am Tag sitzen 16,7 % der Frauen und 22,3 % der Männer: Männer häufiger als Frauen, Jüngere häufiger als Ältere und der Anteil nimmt von der unteren zur oberen Bildungsgruppe deutlich zu. Ebenso sitzt etwa ein Fünftel der Erwachsenen in Deutschland mindestens vier Stunden am Tag und übt keine körperliche Aktivität in der Freizeit aus. Schlussfolgerung: Die Ergebnisse weisen darauf hin, dass präventive Maßnahmen notwendig sind, um Sitzzeiten zu reduzieren und körperliche Aktivität zu steiger