21 research outputs found
Simulation of a high-speed demultiplexer based on two-photon absorption in semiconductor devices
In this paper, we present a theoretical model of an all-optical demultiplexer based on two-photon absorption in a specially designed semiconductor micro-cavity for use in an optical time division multiplexed system. We show that it is possible to achieve error-free demultiplexing of a 250 Gbit/s OTDM signal (25 Ă 10 Gbit/s channels) using a control-to-signal peak pulse power ratios of around 30:1 with a device bandwidth of approximately 30 GHz
All-optical sampling utilising two-photon absorption in semiconductor microcavity
A highly-efficient optical sampling system based on Two-Photon Absorption in a semiconductor micro-cavity is presented. The sensitivity of the sampling system is calculated to be 0.1mWÂČ with a temporal resolution of 2ps
Roughness of Sandpile Surfaces
We study the surface roughness of prototype models displaying self-organized
criticality (SOC) and their noncritical variants in one dimension. For SOC
systems, we find that two seemingly equivalent definitions of surface roughness
yields different asymptotic scaling exponents. Using approximate analytical
arguments and extensive numerical studies we conclude that this ambiguity is
due to the special scaling properties of the nonlinear steady state surface. We
also find that there is no such ambiguity for non-SOC models, although there
may be intermediate crossovers to different roughness values. Such crossovers
need to be distinguished from the true asymptotic behaviour, as in the case of
a noncritical disordered sandpile model studied in [10].Comment: 5 pages, 4 figures. Accepted for publication in Phys. Rev.
A new class of integrable diffusion-reaction processes
We consider a process in which there are two types of particles, A and B, on
an infinite one-dimensional lattice. The particles hop to their adjacent sites,
like the totally asymmetric exclusion process (ASEP), and have also the
following interactions: A+B -> B+B and B+A -> B+B, all occur with equal rate.
We study this process by imposing four boundary conditions on ASEP master
equation. It is shown that this model is integrable, in the sense that its
N-particle S-matrix is factorized into a product of two-particle S-matrices
and, more importantly, the two-particle S-matrix satisfy quantum Yang-Baxter
equation. Using coordinate Bethe-ansatz, the N-particle wavefunctions and the
two-particle conditional probabilities are found exactly.
Further, by imposing four reasonable physical conditions on two-species
diffusion-reaction processes (where the most important ones are the equality of
the reaction rates and the conservation of the number of particles in each
reaction), we show that among the 4096 types of the interactions which have
these properties and can be modeled by a master equation and an appropriate set
of boundary conditions, there are only 28 independent interactions which are
integrable. We find all these interactions and also their corresponding wave
functions. Some of these may be new solutions of quantum Yang-Baxter equation.Comment: LaTex,16 pages, some typos are corrected, will be appeared in Phys.
Rev. E (2000
Novel Phases and Finite-Size Scaling in Two-Species Asymmetric Diffusive Processes
We study a stochastic lattice gas of particles undergoing asymmetric
diffusion in two dimensions. Transitions between a low-density uniform phase
and high-density non-uniform phases characterized by localized or extended
structure are found. We develop a mean-field theory which relates
coarse-grained parameters to microscopic ones. Detailed predictions for
finite-size () scaling and density profiles agree excellently with
simulations. Unusual large- behavior of the transition point parallel to
that of self-organized sandpile models is found.Comment: 7 pages, plus 6 figures uuencoded, compressed and appended after
source code, LATeX, to be published as a Phys. Rev. Let
First- and second-order phase transitions in a driven lattice gas with nearest-neighbor exclusion
A lattice gas with infinite repulsion between particles separated by
lattice spacing, and nearest-neighbor hopping dynamics, is subject to a drive
favoring movement along one axis of the square lattice. The equilibrium (zero
drive) transition to a phase with sublattice ordering, known to be continuous,
shifts to lower density, and becomes discontinuous for large bias. In the
ordered nonequilibrium steady state, both the particle and order-parameter
densities are nonuniform, with a large fraction of the particles occupying a
jammed strip oriented along the drive. The relaxation exhibits features
reminiscent of models of granular and glassy materials.Comment: 8 pages, 5 figures; results due to bad random number generator
corrected; significantly revised conclusion
Quantum Dimensional Zeeman Effect in the Magneto-optical Absorption Spectrum for Quantum Dot - Impurity Center Systems
Magneto-optical properties of the quantum dot - impurity center (QD-IC)
systems synthesized in a transparent dielectric matrix are considered. For the
QD one-electron state description the parabolic model of the confinement
potential is used. Within the framework of zero-range potential model and the
effective mass approach, the light impurity absorption coefficient for the case
of transversal polarization with respect to the applied magnetic field
direction, with consideration of the QD size dispersion, has been analytically
calculated. It is shown that for the case of transversal polarization the light
impurity absorption spectrum is characterized by the quantum dimensional Zeeman
effect.Comment: 18 pages, 1 figure, PDF fil
The genetic architecture of the human cerebral cortex
INTRODUCTION
The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure.
RATIONALE
To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations.
RESULTS
We identified 306 nominally genome-wide significant loci (P < 5 Ă 10â8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 Ă 10â10; 187 influencing surface area and 12 influencing thickness).
Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = â0.32, SE = 0.05, P = 6.5 Ă 10â12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness.
To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity.
We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinsonâs disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism.
CONCLUSION
This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function