Institutionalizing alternative economic spaces? An interpretivist perspective on diverse economies

This article offers an approach that helps geographers and others to carefully and critically reexamine prospects for diverse economies. We propose an interpretative institutionalist perspective is useful for elucidating overlooked opportunities for creating alternative economic visions and practices by revealing the process of ‘meaning making’ undertaken by actors in the process of developing policy responses to various dilemmas. We explore this notion in the context of de-growth or post-growth. De-growth is a way of thinking about the economy in ways that are not growth oriented, or fixated on GDP, but on the redistribution of wealth and living within the Earth’s ecosystems

Properties of quasi two-dimensional condensates in highly anisotropic traps

We theoretically investigate some of the observable properties of quasi two-dimensional condensates. Using a variational model based on a Gaussian-parabolic trial wavefunction we calculate chemical potential, condensate size in time-of-flight, release energy and collective excitation spectrum for varying trap geometries and atom numbers and find good agreement with recent published experimental results.Comment: 7 pages, 4 figure

Thermal induced flow oscillations in heat exchangers for supercritical fluids

Analytical model has been developed to predict possible unstable behavior in supercritical heat exchangers. From complete model, greatly simplified stability criterion is derived. As result of this criterion, stability of heat exchanger system can be predicted in advance

Building consensus for riparian users: toward the twenty-first century

Society\u27s definition of the acceptable use of riparian areas changes over time. Land managers must accept these changes and find ways to help rangeland users work together to develop shared visions for all resources. One approach that has worked for the Oregon Watershed Improvement Coalition (OWIC) is the use of abundance theory and the coalition-building process. Abundance theory focuses attention on the needs of the people and on the importance of understanding one another. This method helps to allay the fear with which many resource users approach on another on resource issues. By using abundance theory and coalition building, OWIC has successfully improved the management and shared vision of Oregon\u27s watersheds and associated riparian areas

Effects of stocking on genetics of wild brook trout populations

http://www.worldcat.org/oclc/1896394

Agriculture and riparian areas

Agriculture has historically been based in the subirrigated riparian ecosystems. Often the engineering and agricultural practices have altered the systems and many of the associated ecological processes. In the Western United States, the most common agricultural practices affecting riparian systems has been livestock grazing. Effects have been both positive and negative. Lack of management has deteriorated many of these systems. Current research has shown what types of management have been successful in allowing grazing by livestock to improve the grazing capacity

Biodiversity as a facet of rangeland research

Biodiversity is only partially a scientific issue. Philosophical and political value systems drive much of the debate and action. Better science would, however, help expose much of what is presently intuitive but may be false. A topic upon which range scientists have much to contribute is how plant diversity relates to successional status of woodlands, grasslands, shrub steppe, and deserts. Correspondence of vegetational change to animal habitats and soil erosion follows. Closer monitoring of large blocks of land under multiple use could lead to a blending of research with management. Definitive understanding of mechanisms will, however, require well-designed manipulated experiments with adequate controls maintained over longer time spans than has been the case in the past

Implementation issues in product line scoping

Often product line engineering is treated similar to the waterfall model in traditional software engineering, i.e., the different phases (scoping, analysis, architecting, implementation) are treated as if they could be clearly separated and would follow each other in an ordered fashion. However, in practice strong interactions between the individual phases become apparent. In particular, how implementation is done has a strong impact on economic aspects of the project and thus how to adequately plan it. Hence, assessing these relationships adequately in the beginning has a strong impact on performing a product line project right. In this paper we present a framework that helps in exactly this task. It captures on an abstract level the relationships between scoping information and implementation aspects and thus allows to provide rough guidance on implementation aspects of the project. We will also discuss the application of our framework to a specific industrial project

Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells.

MicroRNAs are often associated with the pathogenesis of many cancers, including head and neck squamous cell carcinoma (HNSCC). In particular, microRNA-21 (miR-21) appears to have a critical role in tumor cell survival, chemoresistance and HNSCC progression. In this study, we investigated matrix hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with the stem cell markers, Nanog and Stat-3, in HNSCC cells (HSC-3 cells). Our results indicate that HA binding to CD44 promotes Nanog-Stat-3 (also tyrosine phosphorylated Stat-3) complex formation, nuclear translocation and transcriptional activation. Further analyses reveal that miR-21 is controlled by an upstream promoter containing Stat-3 binding site(s), while chromatin immunoprecipitation assays demonstrate that stimulation of miR-21 expression by HA/CD44 signaling is Nanog/Stat-3-dependent in HNSCC cells. This process results in a decrease of a tumor suppressor protein (PDCD4), and an upregulation of i nhibitors of the apoptosis family of proteins (IAPs) as well as chemoresistance in HSC-3 cells. Treatment of HSC-3 cells with Nanog- and/or Stat-3-specific small interfering RNAs effectively blocks HA-mediated Nanog-Stat-3 signaling events, abrogates miR-21 production and increases PDCD4 expression. Subsequently, this Nanog-Stat-3 signaling inhibition causes downregulation of survival protein (IAP) expression and enhancement of chemosensitivity. To further evaluate the role of miR-21 in tumor cell-specific functions, HSC-3 cells were also transfected with a specific anti-miR-21 inhibitor in order to silence miR-21 expression and block its target functions. Our results demonstrate that anti-miR-21 inhibitor not only upregulates PDCD4 expression but also decreases IAP expression and enhances chemosensitivity in HA-treated HNSCC cells. Together, these findings indicate that the HA-induced CD44 interaction with Nanog and Stat-3 has a pivotal role in miR-21 production leading to PDCD4 reduction, IAP upregulation and chemoresistance in HNSCC cells. This novel Nanog/Stat-3 signaling pathway-specific mechanism involved in miR-21 production is significant for the formation of future intervention strategies in the treatment of HA/CD44-activated HNSCC