Weight and mechanical performance optimization of blended composite wing panels using lamination parameters

In this paper, a lamination parameter-based approach to weight optimization of composite aircraft wing structures is addressed. It is a bi-level procedure where at the top level lamination parameters and numbers of plies of the pre-defined angles (0, 90, 45 and −45°) are used as design variables, the material volume is treated as an objective function to be minimized subject to the buckling, strength and ply percentage constraints. At the bottom level the optimum stacking sequence is obtained subject to the requirements on blending and preservation of mechanical properties. To ensure composite blending, a multi-stage optimization is performed by a permutation genetic algorithm aiming at matching the lamination parameters passed from the top level optimization as well as satisfying the layup rules. Two new additional criteria, the 90° ply angle jump index and the stack homogeneity index, are introduced to control the uniformity of the three ply angles (0, 90, 45 and −45) spread throughout the stack as well as improve the stack quality and mechanical performance by encouraging 45° angle change between neighbouring groups of plies. The results of the application of this approach are compared to published results to demonstrate the potential of the developed technique

Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Transcriptional and splicing anomalies have been observed in intron 8 of the CASP8 gene (encoding procaspase-8) in association with cutaneous basal-cell carcinoma (BCC) and linked to a germline SNP rs700635. Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC and breast cancer, is protective against prostate cancer [odds ratio (OR) = 0.91, P = 1.0 × 10(-6)]. rs700635[C] is also associated with failures to correctly splice out CASP8 intron 8 in breast and prostate tumours and in corresponding normal tissues. Investigation of rs700635[C] carriers revealed that they have a human-specific short interspersed element-variable number of tandem repeat-Alu (SINE-VNTR-Alu), subfamily-E retrotransposon (SVA-E) inserted into CASP8 intron 8. The SVA-E shows evidence of prior activity, because it has transduced some CASP8 sequences during subsequent retrotransposition events. Whole-genome sequence (WGS) data were used to tag the SVA-E with a surrogate SNP rs1035142[T] (r(2) = 0.999), which showed associations with both the splicing anomalies (P = 6.5 × 10(-32)) and with protection against prostate cancer (OR = 0.91, P = 3.8 × 10(-7)).National Cancer Research Institute (NCRI) G0500966/75466 Department of Health, Medical Research Council Cancer Research UK University of Cambridge NIHR Department of Health Anniversary Fund of the Austrian National Bank 15079 Medical and Scientific Fund of the Mayor of the City of Vienna 10077 Common Fund of the Office of the Director of the National Institutes of Health NCI NHGRI NHLBI NIDA NIMH NINDS NCI\SAIC-Frederick, Inc. (SAIC-F) 10XS170 Roswell Park Cancer Institute 10XS171 Science Care, Inc. X10S172 SAIC-F 10ST1035 HHSN261200800001E deCODE genetics/AMGEN HHSN268201000029C DA006227 DA033684 N01MH000028 MH090941 MH101814 MH090951 MH090937 MH101820 MH101825 MH090936 MH101819 MH090948 MH101782 MH101810 MH10182

Aberrations in postural control, vibration sensation and some vestibular findings in healthy 64-92-year-old subjects

To assess changes in postural control among healthy elderly and to correlate with suspected age-related events, 33 women and 16 men were studied. Postural control was evaluated by vibration-induced body sway, measured on a force platform, and vibration sensation was tested with a tuning fork. Occurrence of spontaneous gaze and head-shake-induced nystagmus was observed with infrared charged couple device (CCD) cameras and the subjects' medical history was reviewed. Vibration perception was the major determinant for the magnitude of body sway. Although these senior citizens considered themselves healthy, they had a variety of ailments in their medical history, diminished vibration sensation and a high prevalence of vestibular asymmetry. Age per se was not a determinant factor in any of the findings. The study suggests that interest should also be directed to the status of sensation in the legs and vestibular asymmetry when assessing balance function in the elderly. Furthermore, the term "age concomitant" may be more appropriate than "age dependent" when describing decrements of functions such as postural control in elderly subjects

Balance control and adaptation during vibratory perturbations in middle-aged and elderly humans.

The objective was to investigate if healthy elderly people respond and adapt differently to postural disturbances compared to middle-aged people. Thirty middle-aged (mean age 37.8 years, range 24–56 years) and forty healthy elderly subjects (mean age 74.6 years, range 66–88 years) were tested with posturography. Body sway was evoked by applying pseudorandom vibratory stimulation to the belly of the gastrocnemius muscles of both legs simultaneously. The tests were performed both with eyes open and eyes closed. The anteroposterior body sway was measured with a force platform and analyzed with a method that considers the adaptive changes of posture and stimulation responses. The results showed that middle-aged people generally used a different postural control strategy as compared to the elderly. The elderly responded more rapidly to vibratory perturbation, used more high-frequency (>0.1 Hz) motions and the motion dynamics had a higher degree of complexity. Moreover, the elderly had diminished ability to use visual information to improve balance control. Altogether, despite having an effective postural control adaptation similar to that of middle-aged people, the elderly had more difficultly in withstanding balance perturbations. These findings suggest that the balance control deterioration associated with aging cannot be fully compensated for by postural control adaptation

Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis

Hemoglobin is the essential oxygen-carrying molecule in humans and is regulated by cellular iron and oxygen sensing mechanisms. To search for novel variants associated with hemoglobin concentration, we performed genome-wide association studies of hemoglobin concentration using a combined set of 684,122 individuals from Iceland and the UK. Notably, we found seven novel variants, six rare coding and one common, at the ACO1 locus associating with either decreased or increased hemoglobin concentration. Of these variants, the missense Cys506Ser and the stop-gained Lys334Ter mutations are specific to eight and ten generation pedigrees, respectively, and have the two largest effects in the study (EffectCys506Ser = −1.61 SD, CI95 = [−1.98, −1.35]; EffectLys334Ter = 0.63 SD, CI95 = [0.36, 0.91]). We also find Cys506Ser to associate with increased risk of persistent anemia (OR = 17.1, P = 2 × 10−14). The strong bidirectional effects seen in this study implicate ACO1, a known iron sensing molecule, as a major homeostatic regulator of hemoglobin concentration