Symptomatology and Anatomy of Stemgrooving (Legno Riccio) 1n the Grape Vine

External and anatomical differences between organs affected and unaffected by stemgrooving were studied on the wine grape cultivar Chenin blanc and the table grape cultivars Barlinka and Almeria. Cultivar susceptibility, graft transmissibility as well as the effect of the disease on the percentage of take and growth in: the nursery were studied. The probability of an association with other virus diseases was considered. Abnormal behaviour of the vascular cambium of infected vines gave rise to hypertrophy, hyperplasia, hypoplasia and parenchymatoses in the secondary xylem and phloem. In diseased tissues dift'erentiation of pbeDogen proceeded abnormally deep into the phloem rays. Graft transmission was detected anatomically within six months. The disease was found in all the vine growing districts of the Western Cape. Anatomical.studies showed that the disease had been present for many years. A negative effect on the percentage of t:'tKe and growth in the nursery was, recorded. A probable-relationship with corky bark was indicated anatomically and by indexing with LN33

Chlorido{N-[2-(diphenylphosphanyl)- benzyl]-1-(pyridin-2-yl)methanamine-kP} gold(I)

Please refer to full text to view abstrac

Desperate times call for desperate measures: Adapting antiretroviral service delivery in the context of the COVID-19 pandemic

On 23 March 2020, President Cyril Ramaphosa announced a nation-wide lockdown to help curb the spread of the COVID-19 epidemic in South Africa (SA). While these containment measures are considered to have limited the spread of COVID-19 in SA, the economic and social consequences, including the impact on healthcare service delivery, are prominent. Regarding healthcare service delivery, there are concerns about people who could be at risk of experiencing severe COVID-19 infection, and about meeting the needs of people with chronic diseases such as people living with HIV (PLHIV). In the context of the COVID-19 pandemic, PLHIV with an unsuppressed viral load may be at increased risk of developing severe COVID-19-related conditions and potentially dying, especially those who are co-infected with tuberculosis (TB)

Chlorido{N-[2-(diphenyl­phosphan­yl)benz­yl]-1-(pyridin-2-yl)methanamine-κP}gold(I)

In the title compound, [AuCl(C25H23N2P)], the AuI atom is in a typical almost linear coordination environment defined by phosphane P and Cl atoms [bond angle = 175.48 (4)°]. Helical supra­molecular chains along the b axis and mediated by N—H⋯Cl hydrogen bonds feature in the crystal packing

Non-IgE-mediated food allergies

Non-imunoglobulin E (IgE)-mediated conditions include combined IgE and cell-mediated conditions such as atopic dermatitis and eosinophilic oesophagitis, and pure T-cell-mediated conditions such as food protein-induced enterocolitis syndrome, allergic proctocolitis and enteropathy syndromes. Diagnosing mixed or non-IgE-mediated allergy is challenging. A clear cause-effect relationship between exposure to the suspected food and symptoms is not always possible, as symptoms develop over time and are more chronic in nature. Skin-prick tests and specific IgE to the allergen are usually negative. An elimination diet may be necessary to diagnose non-IgE-mediated type food allergy. The suspected allergen should be excluded from the diet for 2 - 6 weeks under dietetic guidance to assess for improvement of symptoms. After symptom improvement, a rechallenge is necessary to definitively prove causal relation.

Strong-coupling expansion and effective hamiltonians

When looking for analytical approaches to treat frustrated quantum magnets, it is often very useful to start from a limit where the ground state is highly degenerate. This chapter discusses several ways of deriving {effective Hamiltonians} around such limits, starting from standard {degenerate perturbation theory} and proceeding to modern approaches more appropriate for the derivation of high-order effective Hamiltonians, such as the perturbative continuous unitary transformations or contractor renormalization. In the course of this exposition, a number of examples taken from the recent literature are discussed, including frustrated ladders and other dimer-based Heisenberg models in a field, as well as the mapping between frustrated Ising models in a transverse field and quantum dimer models.Comment: To appear as a chapter in "Highly Frustrated Magnetism", Eds. C. Lacroix, P. Mendels, F. Mil

Epidemiology of IgE-mediated food allergy

Despite the large number of foods that may cause immunoglobulin E (IgE)-mediated reactions, most prevalence studies have focused on the most common allergenic foods, i.e. cow’s milk, hen’s egg, peanut, tree nut, wheat, soya, fish and shellfish.Food allergy peaks during the first two years of life, and then diminishes towards late childhood as tolerance to several foods develops. Based on meta-analyses and large population-based studies, the true prevalence of food allergy varies from 1% to >10%, depending on the geographical area and age of the patient.The prevalence of food allergy in South Africa (SA) is currently being studied. The prevalence of IgE-mediated food allergy in SA children with moderate-to-severe atopic dermatitis is 40%; however, this represents a high-risk population for food allergy. Preliminary data from the South African Food Sensitisation and Food Allergy (SAFFA) study, which is investigating food allergy in an unselected cohort of 1 - 3-year olds, show a prevalence of 11.6% sensitisation to common foods. Food allergy was most common to egg (1.4%) and peanut (1.1%).Food allergy appears to be the most common trigger of anaphylactic reactions in the community, especially in children, in whom food is responsible for ≥85% of such reactions. In adults, shellfish and nut, and in children, peanut, tree nut, milk and egg, are the most common triggers of food-induced anaphylaxis.

Bacterial loads measured by the Xpert MTB/RIF assay as markers of culture conversion and bacteriological cure in pulmonary TB

Introduction Biomarkers are needed to monitor tuberculosis (TB) treatment and predict treatment outcomes. We evaluated the Xpert MTB/RIF (Xpert) assay as a biomarker for TB treatment during and at the end of the 24 weeks therapy. METHODS: Sputum from 108 HIV-negative, culture-positive pulmonary TB patients was analyzed using Xpert at time points before and during anti-TB therapy. Results were compared against culture. Direct Xpert cycle-threshold (Ct), a change in the Ct (delta Ct), or a novel "percent closing of baseline Ct deficit" (percent closing) were evaluated as classifiers of same-day and end-of-treatment culture and therapeutic outcomes. RESULTS: Xpert was positive in 29/95 (30.5%) of subjects at week 24; and positive one year after treatment in 8/64 (12.5%) successfully-treated patients who remained free of tuberculosis. We identified a relationship between initial bacterial load measured by baseline Xpert Ct and time to culture conversion (hazard ratio 1.06, p = 0.0023), and to the likelihood of being among the 8 treatment failures at week 24 (AUC = 72.8%). Xpert Ct was even more strongly associated with culture conversion on the day the test was performed with AUCs 96.7%, 99.2%, 86.0% and 90.2%, at Day 7, Week 4, 8 and 24, respectively. Compared to baseline Ct measures alone, a combined measure of baseline Ct plus either Delta Ct or percent closing improved the classification of treatment failure status to a 75% sensitivity and 88.9% specificity. CONCLUSIONS: Genome loads measured by Xpert provide a potentially-useful biomarker for classifying same day culture status and predicting response to therapy