Kyste epidermoide intracranien

Introduction: Aim : To evaluate the value of magnetic resonance imaging (MRI) in the diagnosis of 2 cases of epidermoid cysts.Materieal and Methods: 2 cases of histopathologically proven epidermoid cysts were studied. All patients were examined with conventional MRI (T1WI, T2WI, FLAIR) and Diffusion-weighted imaging (DWI).Results: the lesions were located in the right cerebellopontine angle and the right temporal fossa. All lesions were hyperintense on T2, hypointense on T1and strikingly hyperintense on DW.Conclusion: New MR techniques such as FLAIR and DWI are most helpful tools in the specific preoperative diagnosis which is important for surgical guidance

Higher acid recovery efficiency of novel functionalized inorganic/organic composite anion exchange membranes from acidic wastewater

In this work, the synthesis of a series of the functionalized inorganic/organic composite anion exchange membranes (AEMs) was carried out by employing the varying amount of inorganic filler consist of N-(trimethoxysilylpropyl)-N,N,N-trimethylammonium chloride (TMSP-TMA+Cl-) into the quaternized poly (2, 6-dimethyl-1, 4-phenylene oxide) (QPPO) matrix for acid recovery via diffusion dialysis (DD) process. Fourier transform infrared (FTIR) spectroscopy clearly demonstrated the fabrication of the functionalized inorganic/organic composite AEMs and the subsequent membrane characteristic measurements such as ion exchange capacity (IEC), linear swelling ratio (LSR), and water uptake (WR) gave us the optimum loading condition of the filler without undesirable filler particle aggregation. These composite AEMs exhibited IEC of 2.18 to 2.29 meq/g, LSR of 13.33 to 18.52%, and WR of 46.11 to 81.66% with sufficient thermal, chemical, and mechanical stability. The diffusion dialysis (DD) test for acid recovery from artificial acid wastewater of HCl/FeCl2 showed high acid DD coefficient (UH +) (0.022 to 0.025 m/h) and high separation factor (S) (139-260) compared with the commercial membrane. Furthermore, the developed AEMs was acceptably stable (weight loss < 20%) in the acid wastewater at 60 C as an accelerated severe condition for 2 weeks. These results clearly indicated that the developed AEMs have sufficient potential for acid recovery application by DD process.Scopu

Polymorphic variants of SCN1A and EPHX1 influence plasma carbamazepine concentration, metabolism and pharmacoresistance in a population of Kosovar Albanian epileptic patients

Aim The present study aimed to evaluate the effects of gene variants in key genes influencing pharmacokinetic and pharmacodynamic of carbamazepine (CBZ) on the response in patients with epilepsy. Materials & Methods Five SNPs in two candidate genes influencing CBZ transport and metabolism, namely ABCB1 or EPHX1, and CBZ response SCN1A (sodium channel) were genotyped in 145 epileptic patients treated with CBZ as monotherapy and 100 age and sex matched healthy controls. Plasma concentrations of CBZ, carbamazepine-10,11-epoxide (CBZE) and carbamazepine-10,11-trans dihydrodiol (CBZD) were determined by HPLC-UV-DAD and adjusted for CBZ dosage/kg of body weight. Results The presence of the SCN1A IVS5-91G>A variant allele is associated with increased epilepsy susceptibility. Furthermore, carriers of the SCN1A IVS5-91G>A variant or of EPHX1 c.337T>C variant presented significantly lower levels of plasma CBZ compared to carriers of the common alleles (0.71±0.28 vs 1.11±0.69 μg/mL per mg/Kg for SCN1A IVS5-91 AA vs GG and 0.76±0.16 vs 0.94±0.49 μg/mL per mg/Kg for EPHX1 c.337 CC vs TT; PG showed a reduced microsomal epoxide hydrolase activity as reflected by a significantly decreased ratio of CBZD to CBZ (0.13±0.08 to 0.26±0.17, pT SNP and SCN1A 3148A>G variants were not associated with significant changes in CBZ pharmacokinetic. Patients resistant to CBZ treatment showed increased dosage of CBZ (657±285 vs 489±231 mg/day; P<0.001) but also increased plasma levels of CBZ (9.84±4.37 vs 7.41±3.43 μg/mL; P<0.001) compared to patients responsive to CBZ treatment. CBZ resistance was not related to any of the SNPs investigated. Conclusions The SCN1A IVS5-91G>A SNP is associated with susceptibility to epilepsy. SNPs in EPHX1 gene are influencing CBZ metabolism and disposition. CBZ plasma levels are not an indicator of resistance to the therapy

GREEN HYDROGENATION OF AN ALKYNE

International audienc

An experimental evaluation of bow-tie analysis for cybersecurity requirements

Postprint version of published article. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-030-12786-2_11Bow-tie analysis includes a graphical representation for depicting threats and consequences related to unwanted events, and shows how preventive and reactive barriers can provide control over such situations. This kind of analysis has traditionally been used to elicit requirements for safety and reliability engineering, but as a consequence of the ever-increasing coupling between the cyber and physical world, security has become an additional concern. Through a controlled experiment, we provide evidence that the expressiveness of the bow-tie notation is suitable for this purpose as well. Our results show that a sample population of graduate students, inexperienced in security modelling, perform similarly as security experts when we have a well-defined scope and familiar target system/situation. We also demonstrate that misuse case diagrams should be regarded as more of a complementary than competing modelling technique.acceptedVersio

Optimized production and characterization of a detergent-stable protease from Lysinibacillus fusiformis C250R

In this study, we aimed to optimize the cultural and nutritional conditions for protease production by Lysinibacillus fusiformis strain C250R in submerged fermentation process using statistical methodology. The most significant factors (gruel, wheat bran, yeast extract, and FeSO4) were identified by Plackett-Burman design. Response surface methodology (RSM) was used to determine the optimum levels of the screened factors and their interaction. Under the optimized conditions, protease yield 3100&nbsp;U/mL was 4.5 folds higher than those obtained by the use of the initial conditions (680&nbsp;U/mL). Additionally, a new extracellular 51&nbsp;kDa-protease, designated SAPLF, was purified and biochemically characterized from strain C250R. It shows optimum activity at 70&nbsp;°C and pH 10. Its half-life times at 70 and 80&nbsp;°C were 10 and 6-h, respectively. Irreversible inhibition of enzyme activity of SAPLF with serine protease inhibitors demonstrated that it belongs to the serine protease family. Interestingly, its catalytic efficiency was higher than that of SPVP from Aeribacillus pallidus strain VP3 and Alcalase Ultra 2.5&nbsp;L from Bacillus licheniformis. This study demonstrated that SAPLF has a high detergent compatibility and an excellent stain removal compared to Alcalase Ultra 2.5&nbsp;L; which offers an interesting potential for its application in the laundry detergent industry