584 research outputs found
Exploration of novel chemical space: synthesis and in vitro evaluation of N-functionalized tertiary sulfonimidamides
An unprecedented set of structurally diverse sulfonimidamides (47â
compounds) has been prepared by various Nâfunctionalization reactions of tertiary =NH sulfonimidamide 2âaa. These Nâfunctionalization reactions of model compoundâ
2âaa include arylation, alkylation, trifluoromethylation, cyanation, sulfonylation, alkoxycarbonylation (carbamate formation) and aminocarbonylation (urea formation). Small molecule Xâray analyses of selected Nâfunctionalized products are reported. To gain further insight into the properties of sulfonimidamides relevant to medicinal chemistry, a variety of structurally diverse reaction products were tested in selected in vitro assays. The described Nâfunctionalization reactions provide a short and efficient approach to structurally diverse sulfonimidamides which have been the subject of recent, growing interest in the life sciences
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