Judaism as Philosophy

The studies comprising this volume, most of them appearing for the first time in English, deal with some of the main topics in Maimonides’ philosophy and that of his followers in Provence. At the heart of these topics lies the issue of whether they adopted a completely naturalistic picture of the workings of the world order, or left room for the volitional activity of God in history. These topics include divine law, creation, the Account of the Chariot, prophet and sage, Mosaic prophecy, reasons for the commandments, and prayer. Special attention is paid to three lesser known but highly significant Provençal Jewish thinkers: Moses Ibn Tibbon, Levi ben Avraham, and Nissim ben Moses of Marseille

Delimited control operators prove Double-negation Shift

We propose an extension of minimal intuitionistic predicate logic, based on delimited control operators, that can derive the predicate-logic version of the Double-negation Shift schema, while preserving the disjunction and existence properties

On the computational content of Zorn's lemma

We give a computational interpretation to an abstract instance of Zorn's lemma formulated as a wellfoundedness principle in the language of arithmetic in all finite types. This is achieved through G\"odel's functional interpretation, and requires the introduction of a novel form of recursion over non-wellfounded partial orders whose existence in the model of total continuous functionals is proven using domain theoretic techniques. We show that a realizer for the functional interpretation of open induction over the lexicographic ordering on sequences follows as a simple application of our main results

An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants

Obliterative bronchiolitis (OB) is a poorly understood airway disease characterized by the generation of fibrotic bronchiolar occlusions. In the lung transplant setting, OB is a pathological manifestation of bronchiolitis obliterans syndrome (BOS), which is a major impediment to long-term recipient survival. Club cells play a key role in bronchiolar epithelial repair, but whether they promote lung transplant tolerance through preventing OB remains unclear. We determined if OB occurs in mouse orthotopic lung transplants following conditional transgene-targeted club cell depletion. In syngeneic lung transplants club cell depletion leads to transient epithelial injury followed by rapid club cell-mediated repair. In contrast, allogeneic lung transplants develop severe OB lesions and poorly regenerate club cells despite immunosuppression treatment. Lung allograft club cell ablation also triggers the recognition of alloantigens, and pulmonary restricted self-antigens reported associated with BOS development. However, CD8+ T cell depletion restores club cell reparative responses and prevents OB. In addition, ex-vivo analysis reveals a specific role for alloantigen-primed effector CD8+ T cells in preventing club cell proliferation and maintenance. Taken together, we demonstrate a vital role for club cells in maintaining lung transplant tolerance and propose a new model to identify the underlying mechanisms of OB

Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome

Bronchiolitis obliterans syndrome (BOS) is a major impediment to lung transplant survival and is generally resistant to medical therapy. Extracorporeal photophoresis (ECP) is an immunomodulatory therapy that shows promise in stabilizing BOS patients, but its mechanisms of action are unclear. In a mouse lung transplant model, we show that ECP blunts alloimmune responses and inhibits BOS through lowering airway TGF-β bioavailability without altering its expression. Surprisingly, ECP-treated leukocytes were primarily engulfed by alveolar macrophages (AMs), which were reprogrammed to become less responsive to TGF-β and reduce TGF-β bioavailability through secretion of the TGF-β antagonist decorin. In untreated recipients, high airway TGF-β activity stimulated AMs to express CCL2, leading to CCR2+ monocyte-driven BOS development. Moreover, we found TGF-β receptor 2-dependent differentiation of CCR2+ monocytes was required for the generation of monocyte-derived AMs, which in turn promoted BOS by expanding tissue-resident memory CD8+ T cells that inflicted airway injury through Blimp-1-mediated granzyme B expression. Thus, through studying the effects of ECP, we have identified an AM functional plasticity that controls a TGF-β-dependent network that couples CCR2+ monocyte recruitment and differentiation to alloimmunity and BOS

“Others-in-Law”: Legalism in the Economy of Religious Differences

Religious legalism encompasses a wide range of attitudes that assign religious meaning to legal content or to legal compliance. The phenomenology of religious legalism is assuming a significant role in various contemporary debates about legal pluralism, accommodation of religious minorities, religious freedom, and so forth. This article revises this conception and the commonplace equation of Judaism and legalism. It suggests that we ought to regard both as part of the economy of religious differences by which religious identities are expressed and defined as alternatives. The common ascription of religious legalism to Judaism (and Islam) is criticized here through a historical analysis of the law-religion-identity matrix in three cultural settings: late ancient Judeo-Hellenic, medieval Judeo–Arabic, and post-Reformation Europe

Judaism as Philosophy

The studies comprising this volume, most of them appearing for the first time in English, deal with some of the main topics in Maimonides’ philosophy and that of his followers in Provence. At the heart of these topics lies the issue of whether they adopted a completely naturalistic picture of the workings of the world order, or left room for the volitional activity of God in history. These topics include divine law, creation, the Account of the Chariot, prophet and sage, Mosaic prophecy, reasons for the commandments, and prayer. Special attention is paid to three lesser known but highly significant Provençal Jewish thinkers: Moses Ibn Tibbon, Levi ben Avraham, and Nissim ben Moses of Marseille